Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data
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Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data. / Teixeira, Pedro F.; Battelino, Tadej; Carlsson, Anneli; Gudbjörnsdottir, Soffia; Hannelius, Ulf; von Herrath, Matthias; Knip, Mikael; Korsgren, Olle; Elding Larsson, Helena; Lindqvist, Anton; Ludvigsson, Johnny; Lundgren, Markus; Nowak, Christoph; Pettersson, Paul; Pociot, Flemming; Sundberg, Frida; Åkesson, Karin; Lernmark, Åke; Forsander, Gun.
In: Diabetologia, Vol. 67, No. 6, 2024, p. 985-994.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Assisting the implementation of screening for type 1 diabetes by using artificial intelligence on publicly available data
AU - Teixeira, Pedro F.
AU - Battelino, Tadej
AU - Carlsson, Anneli
AU - Gudbjörnsdottir, Soffia
AU - Hannelius, Ulf
AU - von Herrath, Matthias
AU - Knip, Mikael
AU - Korsgren, Olle
AU - Elding Larsson, Helena
AU - Lindqvist, Anton
AU - Ludvigsson, Johnny
AU - Lundgren, Markus
AU - Nowak, Christoph
AU - Pettersson, Paul
AU - Pociot, Flemming
AU - Sundberg, Frida
AU - Åkesson, Karin
AU - Lernmark, Åke
AU - Forsander, Gun
N1 - Publisher Copyright: © The Author(s) 2024.
PY - 2024
Y1 - 2024
N2 - The type 1 diabetes community is coalescing around the benefits and advantages of early screening for disease risk. To be accepted by healthcare providers, regulatory authorities and payers, screening programmes need to show that the testing variables allow accurate risk prediction and that individualised risk-informed monitoring plans are established, as well as operational feasibility, cost-effectiveness and acceptance at population level. Artificial intelligence (AI) has the potential to contribute to solving these issues, starting with the identification and stratification of at-risk individuals. ASSET (AI for Sustainable Prevention of Autoimmunity in the Society; www.asset.healthcare) is a public/private consortium that was established to contribute to research around screening for type 1 diabetes and particularly to how AI can drive the implementation of a precision medicine approach to disease prevention. ASSET will additionally focus on issues pertaining to operational implementation of screening. The authors of this article, researchers and clinicians active in the field of type 1 diabetes, met in an open forum to independently debate key issues around screening for type 1 diabetes and to advise ASSET. The potential use of AI in the analysis of longitudinal data from observational cohort studies to inform the design of improved, more individualised screening programmes was also discussed. A key issue was whether AI would allow the research community and industry to capitalise on large publicly available data repositories to design screening programmes that allow the early detection of individuals at high risk and enable clinical evaluation of preventive therapies. Overall, AI has the potential to revolutionise type 1 diabetes screening, in particular to help identify individuals who are at increased risk of disease and aid in the design of appropriate follow-up plans. We hope that this initiative will stimulate further research on this very timely topic. Graphical Abstract: (Figure presented.)
AB - The type 1 diabetes community is coalescing around the benefits and advantages of early screening for disease risk. To be accepted by healthcare providers, regulatory authorities and payers, screening programmes need to show that the testing variables allow accurate risk prediction and that individualised risk-informed monitoring plans are established, as well as operational feasibility, cost-effectiveness and acceptance at population level. Artificial intelligence (AI) has the potential to contribute to solving these issues, starting with the identification and stratification of at-risk individuals. ASSET (AI for Sustainable Prevention of Autoimmunity in the Society; www.asset.healthcare) is a public/private consortium that was established to contribute to research around screening for type 1 diabetes and particularly to how AI can drive the implementation of a precision medicine approach to disease prevention. ASSET will additionally focus on issues pertaining to operational implementation of screening. The authors of this article, researchers and clinicians active in the field of type 1 diabetes, met in an open forum to independently debate key issues around screening for type 1 diabetes and to advise ASSET. The potential use of AI in the analysis of longitudinal data from observational cohort studies to inform the design of improved, more individualised screening programmes was also discussed. A key issue was whether AI would allow the research community and industry to capitalise on large publicly available data repositories to design screening programmes that allow the early detection of individuals at high risk and enable clinical evaluation of preventive therapies. Overall, AI has the potential to revolutionise type 1 diabetes screening, in particular to help identify individuals who are at increased risk of disease and aid in the design of appropriate follow-up plans. We hope that this initiative will stimulate further research on this very timely topic. Graphical Abstract: (Figure presented.)
KW - AI
KW - Artificial intelligence
KW - ASSET
KW - Children
KW - Precision medicine
KW - Prevention
KW - Screening
KW - Type 1 diabetes
U2 - 10.1007/s00125-024-06089-5
DO - 10.1007/s00125-024-06089-5
M3 - Journal article
C2 - 38353727
AN - SCOPUS:85185118015
VL - 67
SP - 985
EP - 994
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 6
ER -
ID: 383923809