Betydningen af inkretinhormonerne glucose-dependent insulinotropic peptide og glucagon-like peptide-1 for patogenesen ved type 2-diabetes mellitus
Research output: Contribution to journal › Journal article › Research › peer-review
Oral administration of glucose stimulates insulin secretion to a greater extent than does glucose administered as an isoglycaemic intravenous glucose infusion. This phenomenon is called the incretin effect and is caused by the two incretin hormones GIP and GLP-1. In patients with type 2 diabetes, the incretin effect is impaired. The mechanisms of the impaired incretin effect have been found to involve reduced secretion of GLP-1 and a severely impaired effect of GIP. It is currently unknown whether these defects are consequences of the diabetic state or primary pathogenetic factors.
Translated title of the contribution | [Effect of incretin hormones GIP and GLP-1 for the pathogenesis of type 2 diabetes mellitus] |
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Original language | Danish |
Journal | Ugeskrift for Laeger |
Volume | 169 |
Issue number | 22 |
Pages (from-to) | 2101-5 |
Number of pages | 5 |
ISSN | 0041-5782 |
Publication status | Published - 28 May 2007 |
ID: 34145135