Chronic psychological stress seems associated with elements of the metabolic syndrome in patients with ischaemic heart disease
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Chronic psychological stress seems associated with elements of the metabolic syndrome in patients with ischaemic heart disease. / Bergmann, Natasha; Ballegaard, Søren; Krogh, Jesper; Bech, Per; Hjalmarson, Åke; Gyntelberg, Finn; Faber, Jens.
In: Scandinavian Journal of Clinical and Laboratory Investigation, Vol. 77, No. 7, 2017, p. 513-519.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Chronic psychological stress seems associated with elements of the metabolic syndrome in patients with ischaemic heart disease
AU - Bergmann, Natasha
AU - Ballegaard, Søren
AU - Krogh, Jesper
AU - Bech, Per
AU - Hjalmarson, Åke
AU - Gyntelberg, Finn
AU - Faber, Jens
PY - 2017
Y1 - 2017
N2 - Background and objectives: Chronic psychological stress, the metabolic syndrome (MS) and ischaemic heart disease (IHD) seem closely connected. In this study, we evaluate the association between chronic stress and elements of MS in patients with stable IHD. Design: Cross-sectional cohort study. Methods: Three hundred and fifty patients with stable IHD were included. Chronic stress was evaluated by the two questionnaires, Major Depression Inventory (MDI) and the psychological wellbeing index WHO-5, as well as by Pressure Pain Sensitivity (PPS), a physiological measure of hyperalgesia at the sternum known to be associated to elements of the chronic stress syndrome. Elements of MS were evaluated by dual-energy X-ray absorptiometry, body weight, HOMA-IR and blood lipids. Results: Depressive symptoms were associated with a high percentage of body fat (β = 0.179, p =.001), and high level of triglycerides (β = 0.150, p =.007). Low psychological wellbeing was associated with a high percentage of body fat (β = –0.165, p =.002) and low level of HDL cholesterol (β = 0.128, p =.024). Chronic stress measured by PPS was associated with a high percentage body fat (β = 0.327, p <.001), low body weight (β = –0.218, p <.001) and low HDL-cholesterol (β = –0.137, p =.013). Adjusting for several life style factors did not change these results. Conclusions: In patients with stable IHD, different measures of chronic psychological stress seem associated with a high percentage of body fat and adverse blood lipids independent of several lifestyle factors.
AB - Background and objectives: Chronic psychological stress, the metabolic syndrome (MS) and ischaemic heart disease (IHD) seem closely connected. In this study, we evaluate the association between chronic stress and elements of MS in patients with stable IHD. Design: Cross-sectional cohort study. Methods: Three hundred and fifty patients with stable IHD were included. Chronic stress was evaluated by the two questionnaires, Major Depression Inventory (MDI) and the psychological wellbeing index WHO-5, as well as by Pressure Pain Sensitivity (PPS), a physiological measure of hyperalgesia at the sternum known to be associated to elements of the chronic stress syndrome. Elements of MS were evaluated by dual-energy X-ray absorptiometry, body weight, HOMA-IR and blood lipids. Results: Depressive symptoms were associated with a high percentage of body fat (β = 0.179, p =.001), and high level of triglycerides (β = 0.150, p =.007). Low psychological wellbeing was associated with a high percentage of body fat (β = –0.165, p =.002) and low level of HDL cholesterol (β = 0.128, p =.024). Chronic stress measured by PPS was associated with a high percentage body fat (β = 0.327, p <.001), low body weight (β = –0.218, p <.001) and low HDL-cholesterol (β = –0.137, p =.013). Adjusting for several life style factors did not change these results. Conclusions: In patients with stable IHD, different measures of chronic psychological stress seem associated with a high percentage of body fat and adverse blood lipids independent of several lifestyle factors.
KW - body fat
KW - cholesterol
KW - depression
KW - ischaemic heart disease
KW - Metabolic syndrome
KW - stress
KW - wellbeing
U2 - 10.1080/00365513.2017.1354254
DO - 10.1080/00365513.2017.1354254
M3 - Journal article
C2 - 28727492
AN - SCOPUS:85025128124
VL - 77
SP - 513
EP - 519
JO - Scandinavian Journal of Clinical and Laboratory Investigation. Supplement
JF - Scandinavian Journal of Clinical and Laboratory Investigation. Supplement
SN - 0085-591X
IS - 7
ER -
ID: 189152529