Cross-talk between the heart and adipose tissue in cachectic heart failure patients with respect to alterations in body composition: a prospective study
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Cross-talk between the heart and adipose tissue in cachectic heart failure patients with respect to alterations in body composition : a prospective study. / Christensen, Heidi Marie; Kistorp, Caroline; Schou, Morten; Keller, Niels; Zerahn, Bo; Frystyk, Jan; Flyvbjerg, Allan; Faber, Jens.
In: Metabolism, Vol. 63, No. 1, 01.2014, p. 141-149.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Cross-talk between the heart and adipose tissue in cachectic heart failure patients with respect to alterations in body composition
T2 - a prospective study
AU - Christensen, Heidi Marie
AU - Kistorp, Caroline
AU - Schou, Morten
AU - Keller, Niels
AU - Zerahn, Bo
AU - Frystyk, Jan
AU - Flyvbjerg, Allan
AU - Faber, Jens
N1 - © 2013.
PY - 2014/1
Y1 - 2014/1
N2 - OBJECTIVES: Cardiac cachexia (CC) is associated with changes in body composition. Lipolysis and increased energy expenditure caused by A- and B natriuretic peptides (NPs) have been suggested to play a role in CC. We tested the hypothesis that neurohormones and adipokines are associated with body composition in CC and that a progressive loss of fat free mass (FFM) and fat mass (FM) takes place.METHODS: Body composition with regard to FFM, FM, and body fat distribution was assessed by dual energy X-ray absorptiometry (DXA) in 19 non-diabetic patients with chronic heart failure (CHF) and CC and 38 controls (non-cachectic CHF and individuals with prior myocardial infarction-both n = 19) who were followed for 12 months. Biomarkers of neurohormonal stimulation, inflammation, and endothelial dysfunction were measured.RESULTS: N-terminal proBNP (NT-proBNP), midregional proANP (MR-proANP), and total adiponectin were elevated in CHF (p<0.001) and correlated inversely to BMI and FM. An inverse correlation was observed between pro-adrenomedullin (MR-proADM) and FFM. During follow up body weight was unaltered in all groups even though FM increased by 1.35 kg (p<0.05) and FFM decreased by 0.5 kg (p<0.05) in CC patients. The latter correlated inversely to baseline NT-proBNP, MR-proANP, and MR-proADM (p<0.05). No correlation to changes in FM was found.CONCLUSIONS: FM was associated with plasma NPs and total adiponectin at baseline; whereas changes in FM and FFM did not correlate to changes in NPs or adiponectin during follow up. Prospectively, FFM decreased but FM increased, despite stable body weight in CC.
AB - OBJECTIVES: Cardiac cachexia (CC) is associated with changes in body composition. Lipolysis and increased energy expenditure caused by A- and B natriuretic peptides (NPs) have been suggested to play a role in CC. We tested the hypothesis that neurohormones and adipokines are associated with body composition in CC and that a progressive loss of fat free mass (FFM) and fat mass (FM) takes place.METHODS: Body composition with regard to FFM, FM, and body fat distribution was assessed by dual energy X-ray absorptiometry (DXA) in 19 non-diabetic patients with chronic heart failure (CHF) and CC and 38 controls (non-cachectic CHF and individuals with prior myocardial infarction-both n = 19) who were followed for 12 months. Biomarkers of neurohormonal stimulation, inflammation, and endothelial dysfunction were measured.RESULTS: N-terminal proBNP (NT-proBNP), midregional proANP (MR-proANP), and total adiponectin were elevated in CHF (p<0.001) and correlated inversely to BMI and FM. An inverse correlation was observed between pro-adrenomedullin (MR-proADM) and FFM. During follow up body weight was unaltered in all groups even though FM increased by 1.35 kg (p<0.05) and FFM decreased by 0.5 kg (p<0.05) in CC patients. The latter correlated inversely to baseline NT-proBNP, MR-proANP, and MR-proADM (p<0.05). No correlation to changes in FM was found.CONCLUSIONS: FM was associated with plasma NPs and total adiponectin at baseline; whereas changes in FM and FFM did not correlate to changes in NPs or adiponectin during follow up. Prospectively, FFM decreased but FM increased, despite stable body weight in CC.
KW - Absorptiometry, Photon
KW - Adipose Tissue
KW - Adult
KW - Aged
KW - Biological Markers
KW - Body Composition
KW - Cachexia
KW - Chronic Disease
KW - Female
KW - Heart
KW - Heart Failure
KW - Humans
KW - Male
KW - Middle Aged
KW - Natriuretic Peptides
KW - Prospective Studies
U2 - 10.1016/j.metabol.2013.09.017
DO - 10.1016/j.metabol.2013.09.017
M3 - Journal article
C2 - 24140097
VL - 63
SP - 141
EP - 149
JO - Metabolism
JF - Metabolism
SN - 0026-0495
IS - 1
ER -
ID: 138726728