Glucose tolerance in obese pregnant women determines newborn fat mass
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Glucose tolerance in obese pregnant women determines newborn fat mass. / Carlsen, Emma Malchau; Renault, Kristina Martha; Nørgaard, Kirsten; Nilas, Lisbeth; Jensen, Jens-Erik B.; Hitz, Mette Friberg; Michaelsen, Kim F.; Cortes, Dina; Pryds, Ole.
In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 95, No. 4, 2016, p. 429-435.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Glucose tolerance in obese pregnant women determines newborn fat mass
AU - Carlsen, Emma Malchau
AU - Renault, Kristina Martha
AU - Nørgaard, Kirsten
AU - Nilas, Lisbeth
AU - Jensen, Jens-Erik B.
AU - Hitz, Mette Friberg
AU - Michaelsen, Kim F.
AU - Cortes, Dina
AU - Pryds, Ole
N1 - CURIS 2016 NEXS 037
PY - 2016
Y1 - 2016
N2 - INTRODUCTION: Offspring of obese women have both short- and long-term increased morbidities. We investigated the relationship between maternal 2-h plasma glucose level determined by oral glucose tolerance test, degree of obesity, gestational weight gain and total fat, abdominal fat, and fat-free masses in the offspring of obese mothers.MATERIAL AND METHODS: Obese mother-newborn dyads were recruited and 2-h plasma glucose levels were assessed during gestational weeks 27-30; neonatal body composition was measured by dual-energy X-ray absorptiometry scanning (DXA) within 48 hours of birth.RESULTS: Among 264 term, healthy, and singleton infants eligible for inclusion, 248 were included. Of these 205 (83%) obese mother-newborn-dyads had a DXA scan and 2-h plasma glucose measurements. Linear regression analysis showed that birth weight z-scores correlated with 2-h plasma glucose levels (p = 0.002) after adjusting for gestational weight gain, maternal age, education, smoking, pre-pregnancy degree of obesity, parity, and birth length. Total (p = 0.012) and abdominal (p = 0.039) fat masses correlated with 2-h plasma glucose levels after adjusting for gestational weight gain, maternal age, education, smoking, pre-pregnancy degree of obesity, parity, gestational age, and newborn sex. There was no association between total (p = 0.88) and abdominal (p = 0.61) fat-free masses and 2-h plasma glucose.CONCLUSION: At 27-30 weeks of gestation, 2-h plasma glucose levels are related to total and abdominal newborn fat masses, but not to fat-free mass. Interventions targeting maternal postprandial glucose levels may induce more appropriate birth weight, thereby reducing the risk of subsequent morbidity. This article is protected by copyright. All rights reserved.
AB - INTRODUCTION: Offspring of obese women have both short- and long-term increased morbidities. We investigated the relationship between maternal 2-h plasma glucose level determined by oral glucose tolerance test, degree of obesity, gestational weight gain and total fat, abdominal fat, and fat-free masses in the offspring of obese mothers.MATERIAL AND METHODS: Obese mother-newborn dyads were recruited and 2-h plasma glucose levels were assessed during gestational weeks 27-30; neonatal body composition was measured by dual-energy X-ray absorptiometry scanning (DXA) within 48 hours of birth.RESULTS: Among 264 term, healthy, and singleton infants eligible for inclusion, 248 were included. Of these 205 (83%) obese mother-newborn-dyads had a DXA scan and 2-h plasma glucose measurements. Linear regression analysis showed that birth weight z-scores correlated with 2-h plasma glucose levels (p = 0.002) after adjusting for gestational weight gain, maternal age, education, smoking, pre-pregnancy degree of obesity, parity, and birth length. Total (p = 0.012) and abdominal (p = 0.039) fat masses correlated with 2-h plasma glucose levels after adjusting for gestational weight gain, maternal age, education, smoking, pre-pregnancy degree of obesity, parity, gestational age, and newborn sex. There was no association between total (p = 0.88) and abdominal (p = 0.61) fat-free masses and 2-h plasma glucose.CONCLUSION: At 27-30 weeks of gestation, 2-h plasma glucose levels are related to total and abdominal newborn fat masses, but not to fat-free mass. Interventions targeting maternal postprandial glucose levels may induce more appropriate birth weight, thereby reducing the risk of subsequent morbidity. This article is protected by copyright. All rights reserved.
U2 - 10.1111/aogs.12839
DO - 10.1111/aogs.12839
M3 - Journal article
C2 - 26661377
VL - 95
SP - 429
EP - 435
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 4
ER -
ID: 152990441