Glycemia Around Exercise in Adults with Type 1 Diabetes Using Automated and Nonautomated Insulin Delivery Pumps: A Switch Pilot Trial
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Glycemia Around Exercise in Adults with Type 1 Diabetes Using Automated and Nonautomated Insulin Delivery Pumps : A Switch Pilot Trial. / McCarthy, Olivia M.; Christensen, Merete Bechmann; Kristensen, Kasper Birch; Schmidt, Signe; Ranjan, Ajenthen G.; Bain, Stephen C.; Bracken, Richard M.; Nørgaard, Kirsten.
In: Diabetes Technology & Therapeutics, Vol. 25, No. 4, 2023, p. 287-292.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Glycemia Around Exercise in Adults with Type 1 Diabetes Using Automated and Nonautomated Insulin Delivery Pumps
T2 - A Switch Pilot Trial
AU - McCarthy, Olivia M.
AU - Christensen, Merete Bechmann
AU - Kristensen, Kasper Birch
AU - Schmidt, Signe
AU - Ranjan, Ajenthen G.
AU - Bain, Stephen C.
AU - Bracken, Richard M.
AU - Nørgaard, Kirsten
PY - 2023
Y1 - 2023
N2 - In an in-patient switch study, 10 adults with type 1 diabetes (T1D) performed 45 min of moderate-intensity exercise on 2 occasions: (1) when using their usual insulin pump (UP) and (2) after transitioning to automated insulin delivery (AID) treatment (MiniMed™ 780G). Consensus glucose management guidelines for performing exercise were applied. Plasma glucose concentrations measured over a 3-h monitoring period were stratified into time below range (TBR, <3.9 mmol/L), time in range (TIR, 3.9-10.0 mmol/L), and time above range (TAR, >10.0 mmol/L). Overall, TBR (UP: 11 ± 21 vs. AID: 3% ± 10%, P = 0.413), TIR (UP: 53 ± 27 vs. AID: 66% ± 39%, P = 0.320), and TAR (UP: 37 ± 34 vs. AID: 31% ± 41%, P = 0.604) were similar between arms. A proportionately low number of people experienced exercise-induced hypoglycemia (UP: n = 2 vs. AID: n = 1, P = 1.00). In conclusion, switching to AID therapy did not alter patterns of glycemia around sustained moderate-intensity exercise in adults with T1D. Clinical Trial Registration number: NCT05133765.
AB - In an in-patient switch study, 10 adults with type 1 diabetes (T1D) performed 45 min of moderate-intensity exercise on 2 occasions: (1) when using their usual insulin pump (UP) and (2) after transitioning to automated insulin delivery (AID) treatment (MiniMed™ 780G). Consensus glucose management guidelines for performing exercise were applied. Plasma glucose concentrations measured over a 3-h monitoring period were stratified into time below range (TBR, <3.9 mmol/L), time in range (TIR, 3.9-10.0 mmol/L), and time above range (TAR, >10.0 mmol/L). Overall, TBR (UP: 11 ± 21 vs. AID: 3% ± 10%, P = 0.413), TIR (UP: 53 ± 27 vs. AID: 66% ± 39%, P = 0.320), and TAR (UP: 37 ± 34 vs. AID: 31% ± 41%, P = 0.604) were similar between arms. A proportionately low number of people experienced exercise-induced hypoglycemia (UP: n = 2 vs. AID: n = 1, P = 1.00). In conclusion, switching to AID therapy did not alter patterns of glycemia around sustained moderate-intensity exercise in adults with T1D. Clinical Trial Registration number: NCT05133765.
KW - Artificial pancreas
KW - Automated insulin delivery system
KW - Exercise
KW - Type 1 diabetes
U2 - 10.1089/dia.2022.0542
DO - 10.1089/dia.2022.0542
M3 - Journal article
C2 - 36724311
AN - SCOPUS:85152173302
VL - 25
SP - 287
EP - 292
JO - Diabetes Technology & Therapeutics
JF - Diabetes Technology & Therapeutics
SN - 1520-9156
IS - 4
ER -
ID: 344447154