Impact of hypoglycaemia on patient-reported outcomes from a global, 24-country study of 27,585 people with type 1 and insulin-treated type 2 diabetes
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Impact of hypoglycaemia on patient-reported outcomes from a global, 24-country study of 27,585 people with type 1 and insulin-treated type 2 diabetes. / Khunti, Kamlesh; Alsifri, Saud; Aronson, Ronnie; Cigrovski Berković, Maja; Enters-Weijnen, Catherine; Forsén, Tom; Galstyan, Gagik; Geelhoed-Duijvestijn, Petronella; Goldfracht, Margalit; Gydesen, Helge; Kapur, Rahul; Lalic, Nebojsa; Ludvik, Bernhard; Moberg, Erik; Pedersen-Bjergaard, Ulrik; Ramachandran, Ambady; HAT Investigator Group.
In: Diabetes Research and Clinical Practice, Vol. 130, 2017, p. 121-129.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of hypoglycaemia on patient-reported outcomes from a global, 24-country study of 27,585 people with type 1 and insulin-treated type 2 diabetes
AU - Khunti, Kamlesh
AU - Alsifri, Saud
AU - Aronson, Ronnie
AU - Cigrovski Berković, Maja
AU - Enters-Weijnen, Catherine
AU - Forsén, Tom
AU - Galstyan, Gagik
AU - Geelhoed-Duijvestijn, Petronella
AU - Goldfracht, Margalit
AU - Gydesen, Helge
AU - Kapur, Rahul
AU - Lalic, Nebojsa
AU - Ludvik, Bernhard
AU - Moberg, Erik
AU - Pedersen-Bjergaard, Ulrik
AU - Ramachandran, Ambady
AU - HAT Investigator Group
N1 - Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.
PY - 2017
Y1 - 2017
N2 - AIMS: Data on the impact of hypoglycaemia on patients' daily lives and diabetes self-management, particularly in developing countries, are lacking. The aim of this study was to assess fear of, and responses to, hypoglycaemia experienced by patients globally.MATERIALS AND METHODS: This non-interventional, multicentre, 4-week prospective study using self-assessment questionnaires and patient diaries consisted of 27,585 patients, ≥18years, with type 1 diabetes (n=8022) or type 2 diabetes (n=19,563) treated with insulin for >12months, at 2004 sites in 24 countries worldwide.RESULTS: Increased blood glucose monitoring (69.7%) and seeking medical assistance (62.0%) were the most common responses in the 4weeks following hypoglycaemic events for patients with type 1 diabetes and type 2 diabetes, respectively. Approximately 44% of patients with type 1 diabetes or type 2 diabetes increased calorie intake in response to a hypoglycaemic episode. Following hypoglycaemia, 3.9% (type 1 diabetes) and 6.2% (type 2 diabetes) of patients took leave from work or study. Regional differences in fear of, and responses to, hypoglycaemia were evident - in particular, a lower level of hypoglycaemic fear and utilisation of healthcare resources in Northern Europe and Canada.CONCLUSIONS: Hypoglycaemia has a major impact on patients and their behaviour. These global data for the first time reveal regional variations in response to hypoglycaemia and highlight the importance of patient education and management strategies.
AB - AIMS: Data on the impact of hypoglycaemia on patients' daily lives and diabetes self-management, particularly in developing countries, are lacking. The aim of this study was to assess fear of, and responses to, hypoglycaemia experienced by patients globally.MATERIALS AND METHODS: This non-interventional, multicentre, 4-week prospective study using self-assessment questionnaires and patient diaries consisted of 27,585 patients, ≥18years, with type 1 diabetes (n=8022) or type 2 diabetes (n=19,563) treated with insulin for >12months, at 2004 sites in 24 countries worldwide.RESULTS: Increased blood glucose monitoring (69.7%) and seeking medical assistance (62.0%) were the most common responses in the 4weeks following hypoglycaemic events for patients with type 1 diabetes and type 2 diabetes, respectively. Approximately 44% of patients with type 1 diabetes or type 2 diabetes increased calorie intake in response to a hypoglycaemic episode. Following hypoglycaemia, 3.9% (type 1 diabetes) and 6.2% (type 2 diabetes) of patients took leave from work or study. Regional differences in fear of, and responses to, hypoglycaemia were evident - in particular, a lower level of hypoglycaemic fear and utilisation of healthcare resources in Northern Europe and Canada.CONCLUSIONS: Hypoglycaemia has a major impact on patients and their behaviour. These global data for the first time reveal regional variations in response to hypoglycaemia and highlight the importance of patient education and management strategies.
KW - Adult
KW - Canada
KW - Diabetes Mellitus, Type 1/complications
KW - Diabetes Mellitus, Type 2/complications
KW - Europe
KW - Fear
KW - Female
KW - Humans
KW - Hypoglycemia/chemically induced
KW - Hypoglycemic Agents/therapeutic use
KW - Insulin/adverse effects
KW - Male
KW - Middle Aged
KW - Patient Education as Topic
KW - Patient Reported Outcome Measures
KW - Prospective Studies
KW - Self-Management
KW - Surveys and Questionnaires
U2 - 10.1016/j.diabres.2017.05.004
DO - 10.1016/j.diabres.2017.05.004
M3 - Journal article
C2 - 28602812
VL - 130
SP - 121
EP - 129
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
ER -
ID: 197364042