Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele
Research output: Contribution to journal › Journal article › Research › peer-review
We characterised 62 non-diabetic, middle-aged, Caucasians with and without the T risk allele of rs7903146 in TCF7L2 with regard to secretion of insulin, glucagon, glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1) as well as insulin sensitivity and endogenous glucose production. All participants had a 3-hour oral glucose tolerance test (OGTT), an intravenous glucose tolerance test, and a euglycaemic, hyperinsulinaemic clamp. After adjustment for age and sex, risk T allele carriers had higher HbA(1c) levels (P=0.030), reduced first-phase insulin response (P=0.048), higher peripheral insulin sensitivity (P=0.050) and lower fasting GIP concentrations (P=0.003) than CC allele carriers. The latter was also reflected by lower total GIP secretion during the OGTT (P=0.018). We found no significant differences in endogenous glucose production, hepatic insulin sensitivity or fasting concentrations of glucose, insulin, glucagon, and GLP-1 between the groups. The findings suggest that the effect of TCF7L2 on diabetes risk may include reduced secretion of GIP.
Original language | English |
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Journal | Diabetes, Obesity and Metabolism Online |
Volume | 15 |
Issue number | 1 |
Pages (from-to) | 91-95 |
Number of pages | 5 |
ISSN | 1463-1326 |
DOIs | |
Publication status | Published - 2012 |
ID: 40327055