Intake of carbohydrates during pregnancy in obese women is associated with fat mass in the newborn offspring
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Intake of carbohydrates during pregnancy in obese women is associated with fat mass in the newborn offspring. / Renault, Kristina M; Carlsen, Emma M; Nørgaard, Kirsten; Nilas, Lisbeth; Pryds, Ole; Secher, Niels J; Cortes, Dina; Jensen, Jens-Erik Beck; Olsen, Sjurdur F; Halldorsson, Thorhallur I.
In: The American Journal of Clinical Nutrition, Vol. 102, No. 6, 12.2015, p. 1475-81.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Intake of carbohydrates during pregnancy in obese women is associated with fat mass in the newborn offspring
AU - Renault, Kristina M
AU - Carlsen, Emma M
AU - Nørgaard, Kirsten
AU - Nilas, Lisbeth
AU - Pryds, Ole
AU - Secher, Niels J
AU - Cortes, Dina
AU - Jensen, Jens-Erik Beck
AU - Olsen, Sjurdur F
AU - Halldorsson, Thorhallur I
N1 - © 2015 American Society for Nutrition.
PY - 2015/12
Y1 - 2015/12
N2 - BACKGROUND: Transmission of obesity across generations is of concern. Offspring of obese women have short- and long-term increased morbidities. A high intake of carbohydrate during pregnancy combined with impaired glucose tolerance is postulated to result in high birth weight, which is linked to subsequent metabolic disease.OBJECTIVE: The objective was to examine the association between carbohydrate intake in obese pregnant women and their offspring's body composition.DESIGN: Secondary analyses were performed in an observational setting of 222 pregnant women with a pregestational BMI (in kg/m(2)) ≥30 participating in a randomized controlled trial. Diet was assessed at gestational weeks 11-14 and 36-37 by using a semiquantitative food-frequency questionnaire. Body composition in the offspring was assessed at birth by dual-energy X-ray absorptiometry. Relative fat mass (%) was the primary outcome. Absolute measures (total fat, abdominal fat, and lean body mass) were secondary outcomes.RESULTS: Mean ± SD weight and absolute and relative fat mass in the offspring at birth were 3769 ± 542 g, 436 ± 214 g, and 11% ± 4%, respectively. Maternal intake of digestible carbohydrates was associated with the offspring's relative fat mass in late (P-trend = 0.006) but not early (P-trend = 0.15) pregnancy. A comparison of mothers in the highest (median: 238 g/d) compared with the lowest (median: 188 g/d) quartile of digestible carbohydrate intake showed a mean adjusted higher value in the offspring's relative fat mass of 2.1% (95% CI: 0.6%, 3.7%), which corresponded in absolute terms to a 103-g (95% CI: 27, 179-g) higher fat mass. Abdominal fat mass was also higher. In a strata of women with well-controlled glucose (2-h glucose values ≤6.6 mmol/L), no association between carbohydrate intake and offspring fat mass was observed, but the associations became significant and increased in strength with higher intolerance (strata with 2-h glucose values between 6.7-7.7 and ≥7.8 mmol/L).CONCLUSION: In obese women, even those without gestational diabetes but with impaired glucose tolerance, a lower carbohydrate intake at moderate levels in late gestation is associated with a lower fat mass in their offspring at birth. The TOP study was registered at clinicaltrials.gov as NCT01345149.
AB - BACKGROUND: Transmission of obesity across generations is of concern. Offspring of obese women have short- and long-term increased morbidities. A high intake of carbohydrate during pregnancy combined with impaired glucose tolerance is postulated to result in high birth weight, which is linked to subsequent metabolic disease.OBJECTIVE: The objective was to examine the association between carbohydrate intake in obese pregnant women and their offspring's body composition.DESIGN: Secondary analyses were performed in an observational setting of 222 pregnant women with a pregestational BMI (in kg/m(2)) ≥30 participating in a randomized controlled trial. Diet was assessed at gestational weeks 11-14 and 36-37 by using a semiquantitative food-frequency questionnaire. Body composition in the offspring was assessed at birth by dual-energy X-ray absorptiometry. Relative fat mass (%) was the primary outcome. Absolute measures (total fat, abdominal fat, and lean body mass) were secondary outcomes.RESULTS: Mean ± SD weight and absolute and relative fat mass in the offspring at birth were 3769 ± 542 g, 436 ± 214 g, and 11% ± 4%, respectively. Maternal intake of digestible carbohydrates was associated with the offspring's relative fat mass in late (P-trend = 0.006) but not early (P-trend = 0.15) pregnancy. A comparison of mothers in the highest (median: 238 g/d) compared with the lowest (median: 188 g/d) quartile of digestible carbohydrate intake showed a mean adjusted higher value in the offspring's relative fat mass of 2.1% (95% CI: 0.6%, 3.7%), which corresponded in absolute terms to a 103-g (95% CI: 27, 179-g) higher fat mass. Abdominal fat mass was also higher. In a strata of women with well-controlled glucose (2-h glucose values ≤6.6 mmol/L), no association between carbohydrate intake and offspring fat mass was observed, but the associations became significant and increased in strength with higher intolerance (strata with 2-h glucose values between 6.7-7.7 and ≥7.8 mmol/L).CONCLUSION: In obese women, even those without gestational diabetes but with impaired glucose tolerance, a lower carbohydrate intake at moderate levels in late gestation is associated with a lower fat mass in their offspring at birth. The TOP study was registered at clinicaltrials.gov as NCT01345149.
KW - Adipogenesis
KW - Adiposity
KW - Adult
KW - Birth Weight
KW - Body Mass Index
KW - Denmark
KW - Diet, Carbohydrate-Restricted
KW - Diet, Mediterranean
KW - Dietary Carbohydrates
KW - Female
KW - Fetal Development
KW - Glucose Intolerance
KW - Humans
KW - Infant, Newborn
KW - Maternal Nutritional Physiological Phenomena
KW - Obesity
KW - Pediatric Obesity
KW - Pregnancy
KW - Pregnancy Complications
KW - Risk Factors
KW - Self Report
KW - Young Adult
U2 - 10.3945/ajcn.115.110551
DO - 10.3945/ajcn.115.110551
M3 - Journal article
C2 - 26561621
VL - 102
SP - 1475
EP - 1481
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 6
ER -
ID: 161846594