Kombinationsbehandling med thyroxin og trijodthyronin til patienter med hypotyreose

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Kombinationsbehandling med thyroxin og trijodthyronin til patienter med hypotyreose. / Nygaard, Birte; Røder, Michael E; Karmisholt, Jesper; Kristensen, Jette Kolding.

In: Ugeskrift for Laeger, Vol. 180, No. 19, V04170328, 2018.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nygaard, B, Røder, ME, Karmisholt, J & Kristensen, JK 2018, 'Kombinationsbehandling med thyroxin og trijodthyronin til patienter med hypotyreose', Ugeskrift for Laeger, vol. 180, no. 19, V04170328. <http://ugeskriftet.dk/videnskab/kombinationsbehandling-med-thyroxin-og-trijodthyronin-til-patienter-med-hypotyreose>

APA

Nygaard, B., Røder, M. E., Karmisholt, J., & Kristensen, J. K. (2018). Kombinationsbehandling med thyroxin og trijodthyronin til patienter med hypotyreose. Ugeskrift for Laeger, 180(19), [V04170328]. http://ugeskriftet.dk/videnskab/kombinationsbehandling-med-thyroxin-og-trijodthyronin-til-patienter-med-hypotyreose

Vancouver

Nygaard B, Røder ME, Karmisholt J, Kristensen JK. Kombinationsbehandling med thyroxin og trijodthyronin til patienter med hypotyreose. Ugeskrift for Laeger. 2018;180(19). V04170328.

Author

Nygaard, Birte ; Røder, Michael E ; Karmisholt, Jesper ; Kristensen, Jette Kolding. / Kombinationsbehandling med thyroxin og trijodthyronin til patienter med hypotyreose. In: Ugeskrift for Laeger. 2018 ; Vol. 180, No. 19.

Bibtex

@article{52efb9c8c9a34e56892b52d056a78428,
title = "Kombinationsbehandling med thyroxin og trijodthyronin til patienter med hypotyreose",
abstract = "Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.",
keywords = "Drug Therapy, Combination, Humans, Hypothyroidism/drug therapy, Thyroid Hormones/physiology, Thyroxine/administration & dosage, Triiodothyronine/administration & dosage",
author = "Birte Nygaard and R{\o}der, {Michael E} and Jesper Karmisholt and Kristensen, {Jette Kolding}",
year = "2018",
language = "Dansk",
volume = "180",
journal = "Ugeskrift for Laeger",
issn = "0041-5782",
publisher = "Almindelige Danske Laegeforening",
number = "19",

}

RIS

TY - JOUR

T1 - Kombinationsbehandling med thyroxin og trijodthyronin til patienter med hypotyreose

AU - Nygaard, Birte

AU - Røder, Michael E

AU - Karmisholt, Jesper

AU - Kristensen, Jette Kolding

PY - 2018

Y1 - 2018

N2 - Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.

AB - Decreased quality of life is described more often in hypothyroid patients, who are treated with a synthetic form of thyroxine (L-T4), than in euthyroid controls. A combination of L-T4 and a synthetic form of triiodothyronine (L-T3) has been suggested; however, previous meta-analyses on unselected patients did not find any effect. Recent studies demonstrate, that the overall hypothalamic-pituitary-thyroid-tissue homeostasis could be more complex than previously suggested. Polymorphisms in deiodinase and thyroid hormone transporter genes could theoretically explain, why a minor subgroup of hypothyroid patients seem to have an effect of L-T4/L-T3 combination therapy.

KW - Drug Therapy, Combination

KW - Humans

KW - Hypothyroidism/drug therapy

KW - Thyroid Hormones/physiology

KW - Thyroxine/administration & dosage

KW - Triiodothyronine/administration & dosage

M3 - Tidsskriftartikel

C2 - 29761770

VL - 180

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

SN - 0041-5782

IS - 19

M1 - V04170328

ER -

ID: 221761542