Low grade inflammation as measured by levels of YKL-40: association with an increased overall and cardiovascular mortality rate in an elderly population

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Low grade inflammation as measured by levels of YKL-40 : association with an increased overall and cardiovascular mortality rate in an elderly population. / Rathcke, Camilla Noelle; Raymond, Ilan; Kistorp, Caroline; Hildebrandt, Per; Faber, Jens; Vestergaard, Henrik.

In: International Journal of Cardiology, Vol. 143, No. 1, 2010, p. 35-42.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Rathcke, CN, Raymond, I, Kistorp, C, Hildebrandt, P, Faber, J & Vestergaard, H 2010, 'Low grade inflammation as measured by levels of YKL-40: association with an increased overall and cardiovascular mortality rate in an elderly population', International Journal of Cardiology, vol. 143, no. 1, pp. 35-42. https://doi.org/10.1016/j.ijcard.2009.01.043, https://doi.org/10.1016/j.ijcard.2009.01.043

APA

Rathcke, C. N., Raymond, I., Kistorp, C., Hildebrandt, P., Faber, J., & Vestergaard, H. (2010). Low grade inflammation as measured by levels of YKL-40: association with an increased overall and cardiovascular mortality rate in an elderly population. International Journal of Cardiology, 143(1), 35-42. https://doi.org/10.1016/j.ijcard.2009.01.043, https://doi.org/10.1016/j.ijcard.2009.01.043

Vancouver

Rathcke CN, Raymond I, Kistorp C, Hildebrandt P, Faber J, Vestergaard H. Low grade inflammation as measured by levels of YKL-40: association with an increased overall and cardiovascular mortality rate in an elderly population. International Journal of Cardiology. 2010;143(1):35-42. https://doi.org/10.1016/j.ijcard.2009.01.043, https://doi.org/10.1016/j.ijcard.2009.01.043

Author

Rathcke, Camilla Noelle ; Raymond, Ilan ; Kistorp, Caroline ; Hildebrandt, Per ; Faber, Jens ; Vestergaard, Henrik. / Low grade inflammation as measured by levels of YKL-40 : association with an increased overall and cardiovascular mortality rate in an elderly population. In: International Journal of Cardiology. 2010 ; Vol. 143, No. 1. pp. 35-42.

Bibtex

@article{00bf712077b011df928f000ea68e967b,
title = "Low grade inflammation as measured by levels of YKL-40: association with an increased overall and cardiovascular mortality rate in an elderly population",
abstract = "BACKGROUND: Low grade inflammation is of pathogenic importance in the development of cardiovascular disease (CVD) and type 2 diabetes. The inflammation marker YKL-40 correlates with insulin resistance and is highly expressed in atherosclerotic plaques. We aimed to investigate whether YKL-40 could predict overall and cardiovascular (CV) mortality in a 50+ years population without known CVD. METHODS: A representative population sample of 639 individuals aged 50-89 years was recruited from general practices. Examination at baseline included echocardiography and blood and urine samples for CV risk factors and markers including lipids, high sensitive C-reactive protein (hsCRP), N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) and urinary albumin/creatinine-ratio (UACR). Median follow-up period was 5.0 (0.17-5.28) years. RESULTS: In subjects without diabetes and CVD at baseline, increasing YKL-40 levels independently predicted overall and CV mortality rate with hazard ratios of 1.58 (95% confidence interval (CI), 1.12-2.23, p=0.009) and 1.57 (95% CI, 1.00-2.46, p=0.049) after adjustment for age, sex, smoking, total cholesterol, hsCRP, NT-proBNP and UACR. In combined Kaplan-Meier analyses, baseline values of both YKL-40 and UACR above median significantly predicted increased cumulative overall and CV mortality rates in subjects without diabetes or CVD at baseline (30.6% vs.",
author = "Rathcke, {Camilla Noelle} and Ilan Raymond and Caroline Kistorp and Per Hildebrandt and Jens Faber and Henrik Vestergaard",
note = "Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.",
year = "2010",
doi = "10.1016/j.ijcard.2009.01.043",
language = "English",
volume = "143",
pages = "35--42",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

RIS

TY - JOUR

T1 - Low grade inflammation as measured by levels of YKL-40

T2 - association with an increased overall and cardiovascular mortality rate in an elderly population

AU - Rathcke, Camilla Noelle

AU - Raymond, Ilan

AU - Kistorp, Caroline

AU - Hildebrandt, Per

AU - Faber, Jens

AU - Vestergaard, Henrik

N1 - Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.

PY - 2010

Y1 - 2010

N2 - BACKGROUND: Low grade inflammation is of pathogenic importance in the development of cardiovascular disease (CVD) and type 2 diabetes. The inflammation marker YKL-40 correlates with insulin resistance and is highly expressed in atherosclerotic plaques. We aimed to investigate whether YKL-40 could predict overall and cardiovascular (CV) mortality in a 50+ years population without known CVD. METHODS: A representative population sample of 639 individuals aged 50-89 years was recruited from general practices. Examination at baseline included echocardiography and blood and urine samples for CV risk factors and markers including lipids, high sensitive C-reactive protein (hsCRP), N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) and urinary albumin/creatinine-ratio (UACR). Median follow-up period was 5.0 (0.17-5.28) years. RESULTS: In subjects without diabetes and CVD at baseline, increasing YKL-40 levels independently predicted overall and CV mortality rate with hazard ratios of 1.58 (95% confidence interval (CI), 1.12-2.23, p=0.009) and 1.57 (95% CI, 1.00-2.46, p=0.049) after adjustment for age, sex, smoking, total cholesterol, hsCRP, NT-proBNP and UACR. In combined Kaplan-Meier analyses, baseline values of both YKL-40 and UACR above median significantly predicted increased cumulative overall and CV mortality rates in subjects without diabetes or CVD at baseline (30.6% vs.

AB - BACKGROUND: Low grade inflammation is of pathogenic importance in the development of cardiovascular disease (CVD) and type 2 diabetes. The inflammation marker YKL-40 correlates with insulin resistance and is highly expressed in atherosclerotic plaques. We aimed to investigate whether YKL-40 could predict overall and cardiovascular (CV) mortality in a 50+ years population without known CVD. METHODS: A representative population sample of 639 individuals aged 50-89 years was recruited from general practices. Examination at baseline included echocardiography and blood and urine samples for CV risk factors and markers including lipids, high sensitive C-reactive protein (hsCRP), N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP) and urinary albumin/creatinine-ratio (UACR). Median follow-up period was 5.0 (0.17-5.28) years. RESULTS: In subjects without diabetes and CVD at baseline, increasing YKL-40 levels independently predicted overall and CV mortality rate with hazard ratios of 1.58 (95% confidence interval (CI), 1.12-2.23, p=0.009) and 1.57 (95% CI, 1.00-2.46, p=0.049) after adjustment for age, sex, smoking, total cholesterol, hsCRP, NT-proBNP and UACR. In combined Kaplan-Meier analyses, baseline values of both YKL-40 and UACR above median significantly predicted increased cumulative overall and CV mortality rates in subjects without diabetes or CVD at baseline (30.6% vs.

U2 - 10.1016/j.ijcard.2009.01.043

DO - 10.1016/j.ijcard.2009.01.043

M3 - Journal article

C2 - 19223085

VL - 143

SP - 35

EP - 42

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 1

ER -

ID: 20296263