Polycystic ovary syndrome: cardiovascular risk factors according to specific phenotypes
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Polycystic ovary syndrome : cardiovascular risk factors according to specific phenotypes. / Aziz, Mubeena; Sidelmann, Johannes J; Faber, Jens; Wissing, Marie Louise; Naver, Klara V; Mikkelsen, Anne-Lis; Nilas, Lisbeth; Skouby, Sven O.
In: Acta Obstetricia et Gynecologica Scandinavica, Vol. 94, No. 10, 10.2015, p. 1082-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Polycystic ovary syndrome
T2 - cardiovascular risk factors according to specific phenotypes
AU - Aziz, Mubeena
AU - Sidelmann, Johannes J
AU - Faber, Jens
AU - Wissing, Marie Louise
AU - Naver, Klara V
AU - Mikkelsen, Anne-Lis
AU - Nilas, Lisbeth
AU - Skouby, Sven O
N1 - © 2015 Nordic Federation of Societies of Obstetrics and Gynecology.
PY - 2015/10
Y1 - 2015/10
N2 - INTRODUCTION: Polycystic ovary syndrome (PCOS) is associated with obesity and insulin resistance. The objective of this cross-sectional study was to investigate the impact of insulin resistance and body mass index (BMI) on inflammatory and hemostatic variables associated with long-term risk of cardiovascular disease in women with PCOS.MATERIAL AND METHODS: 149 premenopausal women with PCOS were recruited consecutively from April 2010 to February 2012 at three Danish University Hospitals. The study was conducted at the Department of Gynecology and Obstetrics, Herlev University Hospital, Denmark. PCOS was diagnosed in accordance with the Rotterdam criteria and the women were classified into four phenotypes according to BMI and insulin resistance measured by the homeostasis model assessment of insulin resistance index. Body composition was determined by dual-energy X-ray absorptiometry. Main outcome measures were the biomarkers C-reactive protein (CRP), plasminogen activator inhibitor-1 (PAI-1), and von Willebrand factor antigen.RESULTS: Normal weight insulin-resistant PCOS women were characterized by abdominal obesity and elevated levels of plasma PAI-1. Overweight/obese insulin-resistant PCOS women had increased levels of both PAI-1 and CRP. Of the three Rotterdam criteria, only hyperandrogenemia was significantly associated with the hemostatic risk marker of long-term cardiovascular disease risk.CONCLUSIONS: Surrogate risk markers for cardiovascular disease are elevated in women with PCOS, especially insulin-resistant and overweight/obese women.
AB - INTRODUCTION: Polycystic ovary syndrome (PCOS) is associated with obesity and insulin resistance. The objective of this cross-sectional study was to investigate the impact of insulin resistance and body mass index (BMI) on inflammatory and hemostatic variables associated with long-term risk of cardiovascular disease in women with PCOS.MATERIAL AND METHODS: 149 premenopausal women with PCOS were recruited consecutively from April 2010 to February 2012 at three Danish University Hospitals. The study was conducted at the Department of Gynecology and Obstetrics, Herlev University Hospital, Denmark. PCOS was diagnosed in accordance with the Rotterdam criteria and the women were classified into four phenotypes according to BMI and insulin resistance measured by the homeostasis model assessment of insulin resistance index. Body composition was determined by dual-energy X-ray absorptiometry. Main outcome measures were the biomarkers C-reactive protein (CRP), plasminogen activator inhibitor-1 (PAI-1), and von Willebrand factor antigen.RESULTS: Normal weight insulin-resistant PCOS women were characterized by abdominal obesity and elevated levels of plasma PAI-1. Overweight/obese insulin-resistant PCOS women had increased levels of both PAI-1 and CRP. Of the three Rotterdam criteria, only hyperandrogenemia was significantly associated with the hemostatic risk marker of long-term cardiovascular disease risk.CONCLUSIONS: Surrogate risk markers for cardiovascular disease are elevated in women with PCOS, especially insulin-resistant and overweight/obese women.
KW - Adult
KW - Body Mass Index
KW - C-Reactive Protein
KW - Cardiovascular Diseases
KW - Cross-Sectional Studies
KW - Female
KW - Humans
KW - Insulin Resistance
KW - Phenotype
KW - Plasminogen Activator Inhibitor 1
KW - Polycystic Ovary Syndrome
KW - Prospective Studies
KW - Risk Factors
KW - von Willebrand Factor
U2 - 10.1111/aogs.12706
DO - 10.1111/aogs.12706
M3 - Journal article
C2 - 26123797
VL - 94
SP - 1082
EP - 1089
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 10
ER -
ID: 161622743