Prediction of outcome by highly sensitive troponin T in outpatients with chronic systolic left ventricular heart failure
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Prediction of outcome by highly sensitive troponin T in outpatients with chronic systolic left ventricular heart failure. / Egstrup, Michael; Schou, Morten; Tuxen, Christian D; Kistorp, Caroline N; Hildebrandt, Per R; Gustafsson, Finn; Faber, Jens; Gøtze, Jens Peter; Gustafsson, Ida.
In: American Journal of Cardiology, Vol. 110, No. 4, 2012, p. 552-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Prediction of outcome by highly sensitive troponin T in outpatients with chronic systolic left ventricular heart failure
AU - Egstrup, Michael
AU - Schou, Morten
AU - Tuxen, Christian D
AU - Kistorp, Caroline N
AU - Hildebrandt, Per R
AU - Gustafsson, Finn
AU - Faber, Jens
AU - Gøtze, Jens Peter
AU - Gustafsson, Ida
N1 - Copyright © 2012 Elsevier Inc. All rights reserved.
PY - 2012
Y1 - 2012
N2 - Our aim was to assess the prognostic impact of a high-sensitivity cardiac troponin T (hs-cTnT) assay in an outpatient population with chronic systolic left ventricular heart failure (HF). Four hundred sixteen patients with chronic HF and left ventricular ejection fraction ≤ 45% were enrolled in a prospective cohort study. In addition to hs-cTnT, plasma amino-terminal pro-B-type natriuretic peptide was measured at baseline. Mean age was 71 years, 29% were women, 62% had coronary artery disease (CAD), mean left ventricular ejection fraction was 31%, and 57% had abnormal level of hs-cTnT. During 4.4 years of follow-up, 211 (51%) patients died. In multivariate Cox regression models, hs-cTnT was categorized as quartiles or dichotomized by the 99th percentile of a healthy population. Adjusted hazard ratios for all-cause mortality for quartiles 2 to 4, with quartile 1 as reference, were 1.4 (95% confidence interval 0.9 to 2.4, p = 0.16) for quartile 2, 1.7 (0.9 to 2.5, p = 0.12) for quartile 3, and 2.6 (1.6 to 4.4, p
AB - Our aim was to assess the prognostic impact of a high-sensitivity cardiac troponin T (hs-cTnT) assay in an outpatient population with chronic systolic left ventricular heart failure (HF). Four hundred sixteen patients with chronic HF and left ventricular ejection fraction ≤ 45% were enrolled in a prospective cohort study. In addition to hs-cTnT, plasma amino-terminal pro-B-type natriuretic peptide was measured at baseline. Mean age was 71 years, 29% were women, 62% had coronary artery disease (CAD), mean left ventricular ejection fraction was 31%, and 57% had abnormal level of hs-cTnT. During 4.4 years of follow-up, 211 (51%) patients died. In multivariate Cox regression models, hs-cTnT was categorized as quartiles or dichotomized by the 99th percentile of a healthy population. Adjusted hazard ratios for all-cause mortality for quartiles 2 to 4, with quartile 1 as reference, were 1.4 (95% confidence interval 0.9 to 2.4, p = 0.16) for quartile 2, 1.7 (0.9 to 2.5, p = 0.12) for quartile 3, and 2.6 (1.6 to 4.4, p
U2 - 10.1016/j.amjcard.2012.04.033
DO - 10.1016/j.amjcard.2012.04.033
M3 - Journal article
C2 - 22579083
VL - 110
SP - 552
EP - 557
JO - Am. J. Cardiol.
JF - Am. J. Cardiol.
SN - 0002-9149
IS - 4
ER -
ID: 48444519