Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

  • Lotte B Nielsen
  • Fariba Vaziri-Sani
  • Sven Pörksen
  • Andersen, Marie Louise Charlotte M
  • Jannet Svensson
  • Regine Bergholdt
  • Pociot, Flemming
  • Philip Hougaard
  • Carine de Beaufort
  • Luis Castaño
  • Henrik B Mortensen
  • Ake Lernmark
  • Lars Hansen
  • Hvidoere Study Group On Childhood Diabetes
Autoantibodies against the newly established autoantigen in type 1 diabetes, zinc transporter 8, ZnT8, are presented as two types, ZnT8RAb and ZnT8WAb. The rs13266634 variant of the SLC30A8 gene has recently been found to determine the type of ZnT8Ab. The aim of this study was to explore the impact of this genetic variant and the ZnT8Ab on the residual beta-cell function during disease progression the first year after disease diagnosis in children with newly diagnosed type 1 diabetes. This cohort consists of 257 children aged 
Original languageEnglish
JournalAutoimmunity Highlights
Volume44
Issue number8
Pages (from-to)616-23
Number of pages8
ISSN2038-0305
DOIs
Publication statusPublished - Dec 2011

ID: 40180052