Risk factors for development of nephropathy in patients with a diabetic Charcot foot

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Risk factors for development of nephropathy in patients with a diabetic Charcot foot. / Jansen, Rasmus Bo; Holstein, Per E.; Jørgensen, Bo; Møller, Klaus Kirketerp; Svendsen, Ole Lander.

In: BMC Research Notes, Vol. 14, No. 1, 403, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jansen, RB, Holstein, PE, Jørgensen, B, Møller, KK & Svendsen, OL 2021, 'Risk factors for development of nephropathy in patients with a diabetic Charcot foot', BMC Research Notes, vol. 14, no. 1, 403. https://doi.org/10.1186/s13104-021-05811-5

APA

Jansen, R. B., Holstein, P. E., Jørgensen, B., Møller, K. K., & Svendsen, O. L. (2021). Risk factors for development of nephropathy in patients with a diabetic Charcot foot. BMC Research Notes, 14(1), [403]. https://doi.org/10.1186/s13104-021-05811-5

Vancouver

Jansen RB, Holstein PE, Jørgensen B, Møller KK, Svendsen OL. Risk factors for development of nephropathy in patients with a diabetic Charcot foot. BMC Research Notes. 2021;14(1). 403. https://doi.org/10.1186/s13104-021-05811-5

Author

Jansen, Rasmus Bo ; Holstein, Per E. ; Jørgensen, Bo ; Møller, Klaus Kirketerp ; Svendsen, Ole Lander. / Risk factors for development of nephropathy in patients with a diabetic Charcot foot. In: BMC Research Notes. 2021 ; Vol. 14, No. 1.

Bibtex

@article{2fecdf38b69d464c962c954772a5405e,

title = "Risk factors for development of nephropathy in patients with a diabetic Charcot foot",

abstract = "Objective: Charcot foot is a rare complication to neuropathy and can cause severe foot deformities and ulcerations, which often require prolonged antibiotical treatment. The objective of this retrospective study was to investigate whether this treatment is associated to impaired renal function. Results: In total, 163 patients were included, of whom 105 (64%) had received β-lactam antibiotics for a mean total duration of 13.0 months. There was a significant increase in the urine albumin/creatinine ratio in the group that received antibiotics (p = 0.017), and the use of antibiotics was associated to a subsequent diagnosis of nephropathy (p = 0.01). Patients treated with antibiotics had a 21.9% risk of developing subsequent nephropathy versus 5.2% for patients not treated with antibiotics. We suggest increased awareness on signs of nephropathy in patients with severe Charcot foot.",

keywords = "Charcot foot, Diabetes mellitus, Foot ulcer treatment, Nephropathy, Prolonged antibiotics, Risk factor",

author = "Jansen, {Rasmus Bo} and Holstein, {Per E.} and Bo J{\o}rgensen and M{\o}ller, {Klaus Kirketerp} and Svendsen, {Ole Lander}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

doi = "10.1186/s13104-021-05811-5",

language = "English",

volume = "14",

journal = "BMC Research Notes",

issn = "1756-0500",

publisher = "BioMed Central Ltd.",

number = "1",

}

RIS

TY - JOUR

T1 - Risk factors for development of nephropathy in patients with a diabetic Charcot foot

AU - Jansen, Rasmus Bo

AU - Holstein, Per E.

AU - Jørgensen, Bo

AU - Møller, Klaus Kirketerp

AU - Svendsen, Ole Lander

PY - 2021

Y1 - 2021

N2 - Objective: Charcot foot is a rare complication to neuropathy and can cause severe foot deformities and ulcerations, which often require prolonged antibiotical treatment. The objective of this retrospective study was to investigate whether this treatment is associated to impaired renal function. Results: In total, 163 patients were included, of whom 105 (64%) had received β-lactam antibiotics for a mean total duration of 13.0 months. There was a significant increase in the urine albumin/creatinine ratio in the group that received antibiotics (p = 0.017), and the use of antibiotics was associated to a subsequent diagnosis of nephropathy (p = 0.01). Patients treated with antibiotics had a 21.9% risk of developing subsequent nephropathy versus 5.2% for patients not treated with antibiotics. We suggest increased awareness on signs of nephropathy in patients with severe Charcot foot.

AB - Objective: Charcot foot is a rare complication to neuropathy and can cause severe foot deformities and ulcerations, which often require prolonged antibiotical treatment. The objective of this retrospective study was to investigate whether this treatment is associated to impaired renal function. Results: In total, 163 patients were included, of whom 105 (64%) had received β-lactam antibiotics for a mean total duration of 13.0 months. There was a significant increase in the urine albumin/creatinine ratio in the group that received antibiotics (p = 0.017), and the use of antibiotics was associated to a subsequent diagnosis of nephropathy (p = 0.01). Patients treated with antibiotics had a 21.9% risk of developing subsequent nephropathy versus 5.2% for patients not treated with antibiotics. We suggest increased awareness on signs of nephropathy in patients with severe Charcot foot.

KW - Charcot foot

KW - Diabetes mellitus

KW - Foot ulcer treatment

KW - Nephropathy

KW - Prolonged antibiotics

KW - Risk factor

U2 - 10.1186/s13104-021-05811-5

DO - 10.1186/s13104-021-05811-5

M3 - Journal article

C2 - 34717731

AN - SCOPUS:85118435854

VL - 14

JO - BMC Research Notes

JF - BMC Research Notes

SN - 1756-0500

IS - 1

M1 - 403

ER -

ID: 303717406

Department of Clinical Medicine