The changing landscape of acromegaly - an epidemiological perspective
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The changing landscape of acromegaly - an epidemiological perspective. / Rosendal, Christian; Arlien-Søborg, Mai Christiansen; Nielsen, Eigil Husted; Andersen, Marianne Skovsager; Feltoft, Claus Larsen; Kistorp, Caroline; Dekkers, Olaf M; Jørgensen, Jens Otto Lunde; Dal, Jakob.
In: Reviews in Endocrine and Metabolic Disorders, 2024.Research output: Contribution to journal › Review › Research › peer-review
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T1 - The changing landscape of acromegaly - an epidemiological perspective
AU - Rosendal, Christian
AU - Arlien-Søborg, Mai Christiansen
AU - Nielsen, Eigil Husted
AU - Andersen, Marianne Skovsager
AU - Feltoft, Claus Larsen
AU - Kistorp, Caroline
AU - Dekkers, Olaf M
AU - Jørgensen, Jens Otto Lunde
AU - Dal, Jakob
N1 - © 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2024
Y1 - 2024
N2 - Acromegaly is a rare disease and thus challenging to accurately quantify epidemiologically. In this comprehensive literature review, we compare different approaches to studying acromegaly from an epidemiological perspective and describe the temporal evolution of the disease pertaining to epidemiological variables, clinical presentation and mortality. We present updated epidemiological data from the population-based Danish cohort of patients with acromegaly (AcroDEN), along with meta-analyses of existing estimates from around the world.Based on this, we conclude that the incidence, prevalence and age at acromegaly diagnosis are all steadily increasing, but with considerable variation between studies. An increased number of incidental cases may contribute to the increase in incidence and age at diagnosis, respectively. The clinical features at presentation are trending toward a milder disease phenotype at diagnosis, and advances in therapeutic options have reduced the mortality of patients with acromegaly to a level similar to that of the general population. Moreover, the underlying cause of death has shifted from cardiovascular to malignant neoplastic diseases.
AB - Acromegaly is a rare disease and thus challenging to accurately quantify epidemiologically. In this comprehensive literature review, we compare different approaches to studying acromegaly from an epidemiological perspective and describe the temporal evolution of the disease pertaining to epidemiological variables, clinical presentation and mortality. We present updated epidemiological data from the population-based Danish cohort of patients with acromegaly (AcroDEN), along with meta-analyses of existing estimates from around the world.Based on this, we conclude that the incidence, prevalence and age at acromegaly diagnosis are all steadily increasing, but with considerable variation between studies. An increased number of incidental cases may contribute to the increase in incidence and age at diagnosis, respectively. The clinical features at presentation are trending toward a milder disease phenotype at diagnosis, and advances in therapeutic options have reduced the mortality of patients with acromegaly to a level similar to that of the general population. Moreover, the underlying cause of death has shifted from cardiovascular to malignant neoplastic diseases.
U2 - 10.1007/s11154-024-09875-z
DO - 10.1007/s11154-024-09875-z
M3 - Review
C2 - 38337125
JO - Reviews in Endocrine and Metabolic Disorders
JF - Reviews in Endocrine and Metabolic Disorders
SN - 1389-9155
ER -
ID: 383924786