The influence of diabetes mellitus on midregional proadrenomedullin concentrations and prognostic value in heart failure outpatients
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The influence of diabetes mellitus on midregional proadrenomedullin concentrations and prognostic value in heart failure outpatients. / Holmager, Pernille; Schou, Morten; Egstrup, Michael; Gustafsson, Ida; Goetze, Jens Peter; Gustafsson, Finn; Klausen, Tobias Wirenfeldt; Faber, Jens; Kistorp, Caroline.
In: Journal of Cardiac Failure, Vol. 21, No. 3, 03.2015, p. 250-257.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - The influence of diabetes mellitus on midregional proadrenomedullin concentrations and prognostic value in heart failure outpatients
AU - Holmager, Pernille
AU - Schou, Morten
AU - Egstrup, Michael
AU - Gustafsson, Ida
AU - Goetze, Jens Peter
AU - Gustafsson, Finn
AU - Klausen, Tobias Wirenfeldt
AU - Faber, Jens
AU - Kistorp, Caroline
N1 - Copyright © 2015 Elsevier Inc. All rights reserved.
PY - 2015/3
Y1 - 2015/3
N2 - BACKGROUND: Diabetes mellitus (DM) is associated with an adverse outcome in heart failure (HF). Increased concentrations of midregional proadrenomedullin (MR-proADM) have been associated with DM and are predictors of mortality in HF patients. The aim of this study was to elucidate the impact of DM on MR-proADM concentrations and the prognostic value regarding all-cause mortality and hospitalization among HF patients.METHODS AND RESULTS: We included 366 patients from an HF clinic; 69 (19%) had a history of DM and 40 (11%) had newly diagnosed DM (HbA1c ≥48 mmol/mol). The median MR-proADM concentration was unaffected by DM status (P = .20) but increased in HF patients with impaired renal function (P < .001). During a median follow-up of 55 months, 189 died, and 292 either died or were hospitalized. After adjustment for clinically relevant parameters, MR-proADM was associated with all-cause mortality (hazard ratio [HR] 1.3, 95% confidence interval [CI] 1.1-1.4; P = .01) and the combined end point of death and hospitalization (HR 1.2, 95% CI 1.1-1.4; P = .02) per 1 SD increment of ln-transformed variable. No interaction between DM and MR-proADM was found regarding mortality or hospitalization.CONCLUSIONS: Diabetes status had no impact on MR-proADM concentrations or in the predictive ability of MR-proADM in HF patients.
AB - BACKGROUND: Diabetes mellitus (DM) is associated with an adverse outcome in heart failure (HF). Increased concentrations of midregional proadrenomedullin (MR-proADM) have been associated with DM and are predictors of mortality in HF patients. The aim of this study was to elucidate the impact of DM on MR-proADM concentrations and the prognostic value regarding all-cause mortality and hospitalization among HF patients.METHODS AND RESULTS: We included 366 patients from an HF clinic; 69 (19%) had a history of DM and 40 (11%) had newly diagnosed DM (HbA1c ≥48 mmol/mol). The median MR-proADM concentration was unaffected by DM status (P = .20) but increased in HF patients with impaired renal function (P < .001). During a median follow-up of 55 months, 189 died, and 292 either died or were hospitalized. After adjustment for clinically relevant parameters, MR-proADM was associated with all-cause mortality (hazard ratio [HR] 1.3, 95% confidence interval [CI] 1.1-1.4; P = .01) and the combined end point of death and hospitalization (HR 1.2, 95% CI 1.1-1.4; P = .02) per 1 SD increment of ln-transformed variable. No interaction between DM and MR-proADM was found regarding mortality or hospitalization.CONCLUSIONS: Diabetes status had no impact on MR-proADM concentrations or in the predictive ability of MR-proADM in HF patients.
U2 - 10.1016/j.cardfail.2014.12.007
DO - 10.1016/j.cardfail.2014.12.007
M3 - Journal article
C2 - 25528198
VL - 21
SP - 250
EP - 257
JO - Journal of Cardiac Failure
JF - Journal of Cardiac Failure
SN - 1071-9164
IS - 3
ER -
ID: 137409563