Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits

Research output: Contribution to journal › Review › Research › peer-review

Standard

Acute exacerbations of chronic obstructive pulmonary disease : in search of diagnostic biomarkers and treatable traits. / Mathioudakis, Alexander G.; Janssens, Wim; Sivapalan, Pradeesh; Singanayagam, Aran; Dransfield, Mark T.; Jensen, Jens Ulrik Stæhr; Vestbo, Jørgen.

In: Thorax, Vol. 75, No. 6, 06.2020, p. 520-527.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Mathioudakis, AG, Janssens, W, Sivapalan, P, Singanayagam, A, Dransfield, MT, Jensen, JUS & Vestbo, J 2020, 'Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits', Thorax, vol. 75, no. 6, pp. 520-527. https://doi.org/10.1136/thoraxjnl-2019-214484

APA

Mathioudakis, A. G., Janssens, W., Sivapalan, P., Singanayagam, A., Dransfield, M. T., Jensen, J. U. S., & Vestbo, J. (2020). Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits. Thorax, 75(6), 520-527. https://doi.org/10.1136/thoraxjnl-2019-214484

Vancouver

Mathioudakis AG, Janssens W, Sivapalan P, Singanayagam A, Dransfield MT, Jensen JUS et al. Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits. Thorax. 2020 Jun;75(6):520-527. https://doi.org/10.1136/thoraxjnl-2019-214484

Author

Mathioudakis, Alexander G. ; Janssens, Wim ; Sivapalan, Pradeesh ; Singanayagam, Aran ; Dransfield, Mark T. ; Jensen, Jens Ulrik Stæhr ; Vestbo, Jørgen. / Acute exacerbations of chronic obstructive pulmonary disease : in search of diagnostic biomarkers and treatable traits. In: Thorax. 2020 ; Vol. 75, No. 6. pp. 520-527.

Bibtex

@article{4abfc687afa9475c95bd27b98db063a5,
title = "Acute exacerbations of chronic obstructive pulmonary disease: in search of diagnostic biomarkers and treatable traits",
abstract = "Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with a significant mortality, health and economic burden. Their diagnosis, assessment and management remain suboptimal and unchanged for decades. Recent clinical and translational studies revealed that the significant heterogeneity in mechanisms and outcomes of exacerbations could be resolved by grouping them etiologically. This is anticipated to lead to a better understanding of the biological processes that underlie each type of exacerbation and to allow the introduction of precision medicine interventions that could improve outcomes. This review summarises novel data on the diagnosis, phenotyping, targeted treatment and prevention of COPD exacerbations.",
keywords = "COPD Exacerbations",
author = "Mathioudakis, {Alexander G.} and Wim Janssens and Pradeesh Sivapalan and Aran Singanayagam and Dransfield, {Mark T.} and Jensen, {Jens Ulrik St{\ae}hr} and J{\o}rgen Vestbo",
year = "2020",
month = jun,
doi = "10.1136/thoraxjnl-2019-214484",
language = "English",
volume = "75",
pages = "520--527",
journal = "Thorax",
issn = "0040-6376",
publisher = "B M J Group",
number = "6",

}

RIS

TY - JOUR

T1 - Acute exacerbations of chronic obstructive pulmonary disease

T2 - in search of diagnostic biomarkers and treatable traits

AU - Mathioudakis, Alexander G.

AU - Janssens, Wim

AU - Sivapalan, Pradeesh

AU - Singanayagam, Aran

AU - Dransfield, Mark T.

AU - Jensen, Jens Ulrik Stæhr

AU - Vestbo, Jørgen

PY - 2020/6

Y1 - 2020/6

N2 - Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with a significant mortality, health and economic burden. Their diagnosis, assessment and management remain suboptimal and unchanged for decades. Recent clinical and translational studies revealed that the significant heterogeneity in mechanisms and outcomes of exacerbations could be resolved by grouping them etiologically. This is anticipated to lead to a better understanding of the biological processes that underlie each type of exacerbation and to allow the introduction of precision medicine interventions that could improve outcomes. This review summarises novel data on the diagnosis, phenotyping, targeted treatment and prevention of COPD exacerbations.

AB - Acute exacerbations of chronic obstructive pulmonary disease (COPD) are associated with a significant mortality, health and economic burden. Their diagnosis, assessment and management remain suboptimal and unchanged for decades. Recent clinical and translational studies revealed that the significant heterogeneity in mechanisms and outcomes of exacerbations could be resolved by grouping them etiologically. This is anticipated to lead to a better understanding of the biological processes that underlie each type of exacerbation and to allow the introduction of precision medicine interventions that could improve outcomes. This review summarises novel data on the diagnosis, phenotyping, targeted treatment and prevention of COPD exacerbations.

KW - COPD Exacerbations

U2 - 10.1136/thoraxjnl-2019-214484

DO - 10.1136/thoraxjnl-2019-214484

M3 - Review

C2 - 32217784

AN - SCOPUS:85082511130

VL - 75

SP - 520

EP - 527

JO - Thorax

JF - Thorax

SN - 0040-6376

IS - 6

ER -

ID: 244277037