Standard
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. / Gudbjartsson, Daniel F; Bjornsdottir, Unnur S; Halapi, Eva; Helgadottir, Anna; Sulem, Patrick; Jonsdottir, Gudrun M; Thorleifsson, Gudmar; Helgadottir, Hafdis; Steinthorsdottir, Valgerdur; Stefansson, Hreinn; Williams, Carolyn; Hui, Jennie; Beilby, John; Warrington, Nicole M; James, Alan; Palmer, Lyle J; Koppelman, Gerard H; Heinzmann, Andrea; Krueger, Marcus; Boezen, H Marike; Wheatley, Amanda; Altmuller, Janine; Shin, Hyoung Doo; Uh, Soo-Taek; Cheong, Hyun Sub; Jonsdottir, Brynja; Gislason, David; Park, Choon-Sik; Rasmussen, Linda M; Porsbjerg, Celeste; Hansen, Jakob W; Backer, Vibeke; Werge, Thomas; Janson, Christer; Jönsson, Ulla-Britt; Ng, Maggie C Y; Chan, Juliana; So, Wing Yee; Ma, Ronald; Shah, Svati H; Granger, Christopher B; Quyyumi, Arshed A; Levey, Allan I; Vaccarino, Viola; Reilly, Muredach P; Rader, Daniel J; Williams, Michael J A; van Rij, Andre M; Jones, Gregory T; Trabetti, Elisabetta; Malerba, Giovanni; Pignatti, Pier Franco; Boner, Attilio; Pescollderungg, Lydia; Girelli, Domenico; Olivieri, Oliviero; Martinelli, Nicola; Ludviksson, Bjorn R; Ludviksdottir, Dora; Eyjolfsson, Gudmundur I; Arnar, David; Thorgeirsson, Gudmundur; Deichmann, Klaus; Thompson, Philip J; Wjst, Matthias; Hall, Ian P; Postma, Dirkje S; Gislason, Thorarinn; Gulcher, Jeffrey; Kong, Augustine; Jonsdottir, Ingileif; Thorsteinsdottir, Unnur; Stefansson, Kari; Gudbjartsson, Daniel F; Bjornsdottir, Unnur S; Halapi, Eva; Helgadottir, Anna; Sulem, Patrick; Jonsdottir, Gudrun M; Thorleifsson, Gudmar; Helgadottir, Hafdis; Steinthorsdottir, Valgerdur; Stefansson, Hreinn; Williams, Carolyn; Hui, Jennie; Beilby, John; Warrington, Nicole M; James, Alan; Palmer, Lyle J; Koppelman, Gerard H; Heinzmann, Andrea; Krueger, Marcus; Boezen, H Marike; Wheatley, Amanda; Altmuller, Janine; Shin, Hyoung Doo; Uh, Soo-Taek; Cheong, Hyun Sub; Jonsdottir, Brynja; Gislason, David; Park, Choon-Sik; Rasmussen, Linda M; Porsbjerg, Celeste Michala; Hansen, Jakob W; Backer, Vibeke; Werge, Thomas; Janson, Christer; Jönsson, Ulla-Britt; Ng, Maggie C Y; Chan, Juliana; So, Wing Yee; Ma, Ronald; Shah, Svati H; Granger, Christopher B; Quyyumi, Arshed A; Levey, Allan I; Vaccarino, Viola; Reilly, Muredach P; Rader, Daniel J; Williams, Michael J A; van Rij, Andre M; Jones, Gregory T; Trabetti, Elisabetta; Malerba, Giovanni; Pignatti, Pier Franco; Boner, Attilio; Pescollderungg, Lydia; Girelli, Domenico; Olivieri, Oliviero; Martinelli, Nicola; Ludviksson, Bjorn R; Ludviksdottir, Dora; Eyjolfsson, Gudmundur I; Arnar, David; Thorgeirsson, Gudmundur; Deichmann, Klaus; Thompson, Philip J; Wjst, Matthias; Hall, Ian P; Postma, Dirkje S; Gislason, Thorarinn; Gulcher, Jeffrey; Kong, Augustine; Jonsdottir, Ingileif; Thorsteinsdottir, Unnur; Stefansson, Kari.
In:
Nature Genetics, Vol. 41, No. 3, 2009, p. 342-7.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Gudbjartsson, DF, Bjornsdottir, US, Halapi, E, Helgadottir, A, Sulem, P, Jonsdottir, GM, Thorleifsson, G, Helgadottir, H, Steinthorsdottir, V, Stefansson, H, Williams, C, Hui, J, Beilby, J, Warrington, NM, James, A, Palmer, LJ, Koppelman, GH, Heinzmann, A, Krueger, M, Boezen, HM, Wheatley, A, Altmuller, J, Shin, HD, Uh, S-T, Cheong, HS, Jonsdottir, B, Gislason, D, Park, C-S, Rasmussen, LM
, Porsbjerg, C, Hansen, JW
, Backer, V, Werge, T, Janson, C, Jönsson, U-B, Ng, MCY, Chan, J, So, WY, Ma, R, Shah, SH, Granger, CB, Quyyumi, AA, Levey, AI, Vaccarino, V, Reilly, MP, Rader, DJ, Williams, MJA, van Rij, AM, Jones, GT, Trabetti, E, Malerba, G, Pignatti, PF, Boner, A, Pescollderungg, L, Girelli, D, Olivieri, O, Martinelli, N, Ludviksson, BR, Ludviksdottir, D, Eyjolfsson, GI, Arnar, D, Thorgeirsson, G, Deichmann, K, Thompson, PJ, Wjst, M, Hall, IP, Postma, DS, Gislason, T, Gulcher, J, Kong, A, Jonsdottir, I, Thorsteinsdottir, U, Stefansson, K, Gudbjartsson, DF, Bjornsdottir, US, Halapi, E, Helgadottir, A, Sulem, P, Jonsdottir, GM, Thorleifsson, G, Helgadottir, H, Steinthorsdottir, V, Stefansson, H, Williams, C, Hui, J, Beilby, J, Warrington, NM, James, A, Palmer, LJ, Koppelman, GH, Heinzmann, A, Krueger, M, Boezen, HM, Wheatley, A, Altmuller, J, Shin, HD, Uh, S-T, Cheong, HS, Jonsdottir, B, Gislason, D, Park, C-S, Rasmussen, LM, Porsbjerg, CM, Hansen, JW
, Backer, V, Werge, T, Janson, C, Jönsson, U-B, Ng, MCY, Chan, J, So, WY, Ma, R, Shah, SH, Granger, CB, Quyyumi, AA, Levey, AI, Vaccarino, V, Reilly, MP, Rader, DJ, Williams, MJA, van Rij, AM, Jones, GT, Trabetti, E, Malerba, G, Pignatti, PF, Boner, A, Pescollderungg, L, Girelli, D, Olivieri, O, Martinelli, N, Ludviksson, BR, Ludviksdottir, D, Eyjolfsson, GI, Arnar, D, Thorgeirsson, G, Deichmann, K, Thompson, PJ, Wjst, M, Hall, IP, Postma, DS, Gislason, T, Gulcher, J, Kong, A, Jonsdottir, I, Thorsteinsdottir, U & Stefansson, K 2009, '
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction',
Nature Genetics, vol. 41, no. 3, pp. 342-7.
https://doi.org/10.1038/ng.323,
https://doi.org/10.1038/ng.323APA
Gudbjartsson, D. F., Bjornsdottir, U. S., Halapi, E., Helgadottir, A., Sulem, P., Jonsdottir, G. M., Thorleifsson, G., Helgadottir, H., Steinthorsdottir, V., Stefansson, H., Williams, C., Hui, J., Beilby, J., Warrington, N. M., James, A., Palmer, L. J., Koppelman, G. H., Heinzmann, A., Krueger, M., ... Stefansson, K. (2009).
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
Nature Genetics,
41(3), 342-7.
https://doi.org/10.1038/ng.323,
https://doi.org/10.1038/ng.323Vancouver
Author
Gudbjartsson, Daniel F ; Bjornsdottir, Unnur S ; Halapi, Eva ; Helgadottir, Anna ; Sulem, Patrick ; Jonsdottir, Gudrun M ; Thorleifsson, Gudmar ; Helgadottir, Hafdis ; Steinthorsdottir, Valgerdur ; Stefansson, Hreinn ; Williams, Carolyn ; Hui, Jennie ; Beilby, John ; Warrington, Nicole M ; James, Alan ; Palmer, Lyle J ; Koppelman, Gerard H ; Heinzmann, Andrea ; Krueger, Marcus ; Boezen, H Marike ; Wheatley, Amanda ; Altmuller, Janine ; Shin, Hyoung Doo ; Uh, Soo-Taek ; Cheong, Hyun Sub ; Jonsdottir, Brynja ; Gislason, David ; Park, Choon-Sik ; Rasmussen, Linda M ; Porsbjerg, Celeste ; Hansen, Jakob W ; Backer, Vibeke ; Werge, Thomas ; Janson, Christer ; Jönsson, Ulla-Britt ; Ng, Maggie C Y ; Chan, Juliana ; So, Wing Yee ; Ma, Ronald ; Shah, Svati H ; Granger, Christopher B ; Quyyumi, Arshed A ; Levey, Allan I ; Vaccarino, Viola ; Reilly, Muredach P ; Rader, Daniel J ; Williams, Michael J A ; van Rij, Andre M ; Jones, Gregory T ; Trabetti, Elisabetta ; Malerba, Giovanni ; Pignatti, Pier Franco ; Boner, Attilio ; Pescollderungg, Lydia ; Girelli, Domenico ; Olivieri, Oliviero ; Martinelli, Nicola ; Ludviksson, Bjorn R ; Ludviksdottir, Dora ; Eyjolfsson, Gudmundur I ; Arnar, David ; Thorgeirsson, Gudmundur ; Deichmann, Klaus ; Thompson, Philip J ; Wjst, Matthias ; Hall, Ian P ; Postma, Dirkje S ; Gislason, Thorarinn ; Gulcher, Jeffrey ; Kong, Augustine ; Jonsdottir, Ingileif ; Thorsteinsdottir, Unnur ; Stefansson, Kari ; Gudbjartsson, Daniel F ; Bjornsdottir, Unnur S ; Halapi, Eva ; Helgadottir, Anna ; Sulem, Patrick ; Jonsdottir, Gudrun M ; Thorleifsson, Gudmar ; Helgadottir, Hafdis ; Steinthorsdottir, Valgerdur ; Stefansson, Hreinn ; Williams, Carolyn ; Hui, Jennie ; Beilby, John ; Warrington, Nicole M ; James, Alan ; Palmer, Lyle J ; Koppelman, Gerard H ; Heinzmann, Andrea ; Krueger, Marcus ; Boezen, H Marike ; Wheatley, Amanda ; Altmuller, Janine ; Shin, Hyoung Doo ; Uh, Soo-Taek ; Cheong, Hyun Sub ; Jonsdottir, Brynja ; Gislason, David ; Park, Choon-Sik ; Rasmussen, Linda M ; Porsbjerg, Celeste Michala ; Hansen, Jakob W ; Backer, Vibeke ; Werge, Thomas ; Janson, Christer ; Jönsson, Ulla-Britt ; Ng, Maggie C Y ; Chan, Juliana ; So, Wing Yee ; Ma, Ronald ; Shah, Svati H ; Granger, Christopher B ; Quyyumi, Arshed A ; Levey, Allan I ; Vaccarino, Viola ; Reilly, Muredach P ; Rader, Daniel J ; Williams, Michael J A ; van Rij, Andre M ; Jones, Gregory T ; Trabetti, Elisabetta ; Malerba, Giovanni ; Pignatti, Pier Franco ; Boner, Attilio ; Pescollderungg, Lydia ; Girelli, Domenico ; Olivieri, Oliviero ; Martinelli, Nicola ; Ludviksson, Bjorn R ; Ludviksdottir, Dora ; Eyjolfsson, Gudmundur I ; Arnar, David ; Thorgeirsson, Gudmundur ; Deichmann, Klaus ; Thompson, Philip J ; Wjst, Matthias ; Hall, Ian P ; Postma, Dirkje S ; Gislason, Thorarinn ; Gulcher, Jeffrey ; Kong, Augustine ; Jonsdottir, Ingileif ; Thorsteinsdottir, Unnur ; Stefansson, Kari. / Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. In: Nature Genetics. 2009 ; Vol. 41, No. 3. pp. 342-7.
Bibtex
@article{5dc813b0a5f811df928f000ea68e967b,
title = "Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction",
abstract = "Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).",
author = "Gudbjartsson, {Daniel F} and Bjornsdottir, {Unnur S} and Eva Halapi and Anna Helgadottir and Patrick Sulem and Jonsdottir, {Gudrun M} and Gudmar Thorleifsson and Hafdis Helgadottir and Valgerdur Steinthorsdottir and Hreinn Stefansson and Carolyn Williams and Jennie Hui and John Beilby and Warrington, {Nicole M} and Alan James and Palmer, {Lyle J} and Koppelman, {Gerard H} and Andrea Heinzmann and Marcus Krueger and Boezen, {H Marike} and Amanda Wheatley and Janine Altmuller and Shin, {Hyoung Doo} and Soo-Taek Uh and Cheong, {Hyun Sub} and Brynja Jonsdottir and David Gislason and Choon-Sik Park and Rasmussen, {Linda M} and Celeste Porsbjerg and Hansen, {Jakob W} and Vibeke Backer and Thomas Werge and Christer Janson and Ulla-Britt J{\"o}nsson and Ng, {Maggie C Y} and Juliana Chan and So, {Wing Yee} and Ronald Ma and Shah, {Svati H} and Granger, {Christopher B} and Quyyumi, {Arshed A} and Levey, {Allan I} and Viola Vaccarino and Reilly, {Muredach P} and Rader, {Daniel J} and Williams, {Michael J A} and {van Rij}, {Andre M} and Jones, {Gregory T} and Elisabetta Trabetti and Giovanni Malerba and Pignatti, {Pier Franco} and Attilio Boner and Lydia Pescollderungg and Domenico Girelli and Oliviero Olivieri and Nicola Martinelli and Ludviksson, {Bjorn R} and Dora Ludviksdottir and Eyjolfsson, {Gudmundur I} and David Arnar and Gudmundur Thorgeirsson and Klaus Deichmann and Thompson, {Philip J} and Matthias Wjst and Hall, {Ian P} and Postma, {Dirkje S} and Thorarinn Gislason and Jeffrey Gulcher and Augustine Kong and Ingileif Jonsdottir and Unnur Thorsteinsdottir and Kari Stefansson and Gudbjartsson, {Daniel F} and Bjornsdottir, {Unnur S} and Eva Halapi and Anna Helgadottir and Patrick Sulem and Jonsdottir, {Gudrun M} and Gudmar Thorleifsson and Hafdis Helgadottir and Valgerdur Steinthorsdottir and Hreinn Stefansson and Carolyn Williams and Jennie Hui and John Beilby and Warrington, {Nicole M} and Alan James and Palmer, {Lyle J} and Koppelman, {Gerard H} and Andrea Heinzmann and Marcus Krueger and Boezen, {H Marike} and Amanda Wheatley and Janine Altmuller and Shin, {Hyoung Doo} and Soo-Taek Uh and Cheong, {Hyun Sub} and Brynja Jonsdottir and David Gislason and Choon-Sik Park and Rasmussen, {Linda M} and Porsbjerg, {Celeste Michala} and Hansen, {Jakob W} and Vibeke Backer and Thomas Werge and Christer Janson and Ulla-Britt J{\"o}nsson and Ng, {Maggie C Y} and Juliana Chan and So, {Wing Yee} and Ronald Ma and Shah, {Svati H} and Granger, {Christopher B} and Quyyumi, {Arshed A} and Levey, {Allan I} and Viola Vaccarino and Reilly, {Muredach P} and Rader, {Daniel J} and Williams, {Michael J A} and {van Rij}, {Andre M} and Jones, {Gregory T} and Elisabetta Trabetti and Giovanni Malerba and Pignatti, {Pier Franco} and Attilio Boner and Lydia Pescollderungg and Domenico Girelli and Oliviero Olivieri and Nicola Martinelli and Ludviksson, {Bjorn R} and Dora Ludviksdottir and Eyjolfsson, {Gudmundur I} and David Arnar and Gudmundur Thorgeirsson and Klaus Deichmann and Thompson, {Philip J} and Matthias Wjst and Hall, {Ian P} and Postma, {Dirkje S} and Thorarinn Gislason and Jeffrey Gulcher and Augustine Kong and Ingileif Jonsdottir and Unnur Thorsteinsdottir and Kari Stefansson",
note = "Keywords: Adaptor Proteins, Vesicular Transport; Algorithms; Asthma; Case-Control Studies; Eosinophils; Eye Proteins; Genes, myb; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Iceland; Interleukins; Leukocyte Count; Myocardial Infarction; Polymorphism, Single Nucleotide; Proteins; Receptors, Cell Surface",
year = "2009",
doi = "10.1038/ng.323",
language = "English",
volume = "41",
pages = "342--7",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "3",
}
RIS
TY - JOUR
T1 - Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
AU - Gudbjartsson, Daniel F
AU - Bjornsdottir, Unnur S
AU - Halapi, Eva
AU - Helgadottir, Anna
AU - Sulem, Patrick
AU - Jonsdottir, Gudrun M
AU - Thorleifsson, Gudmar
AU - Helgadottir, Hafdis
AU - Steinthorsdottir, Valgerdur
AU - Stefansson, Hreinn
AU - Williams, Carolyn
AU - Hui, Jennie
AU - Beilby, John
AU - Warrington, Nicole M
AU - James, Alan
AU - Palmer, Lyle J
AU - Koppelman, Gerard H
AU - Heinzmann, Andrea
AU - Krueger, Marcus
AU - Boezen, H Marike
AU - Wheatley, Amanda
AU - Altmuller, Janine
AU - Shin, Hyoung Doo
AU - Uh, Soo-Taek
AU - Cheong, Hyun Sub
AU - Jonsdottir, Brynja
AU - Gislason, David
AU - Park, Choon-Sik
AU - Rasmussen, Linda M
AU - Porsbjerg, Celeste
AU - Hansen, Jakob W
AU - Backer, Vibeke
AU - Werge, Thomas
AU - Janson, Christer
AU - Jönsson, Ulla-Britt
AU - Ng, Maggie C Y
AU - Chan, Juliana
AU - So, Wing Yee
AU - Ma, Ronald
AU - Shah, Svati H
AU - Granger, Christopher B
AU - Quyyumi, Arshed A
AU - Levey, Allan I
AU - Vaccarino, Viola
AU - Reilly, Muredach P
AU - Rader, Daniel J
AU - Williams, Michael J A
AU - van Rij, Andre M
AU - Jones, Gregory T
AU - Trabetti, Elisabetta
AU - Malerba, Giovanni
AU - Pignatti, Pier Franco
AU - Boner, Attilio
AU - Pescollderungg, Lydia
AU - Girelli, Domenico
AU - Olivieri, Oliviero
AU - Martinelli, Nicola
AU - Ludviksson, Bjorn R
AU - Ludviksdottir, Dora
AU - Eyjolfsson, Gudmundur I
AU - Arnar, David
AU - Thorgeirsson, Gudmundur
AU - Deichmann, Klaus
AU - Thompson, Philip J
AU - Wjst, Matthias
AU - Hall, Ian P
AU - Postma, Dirkje S
AU - Gislason, Thorarinn
AU - Gulcher, Jeffrey
AU - Kong, Augustine
AU - Jonsdottir, Ingileif
AU - Thorsteinsdottir, Unnur
AU - Stefansson, Kari
AU - Gudbjartsson, Daniel F
AU - Bjornsdottir, Unnur S
AU - Halapi, Eva
AU - Helgadottir, Anna
AU - Sulem, Patrick
AU - Jonsdottir, Gudrun M
AU - Thorleifsson, Gudmar
AU - Helgadottir, Hafdis
AU - Steinthorsdottir, Valgerdur
AU - Stefansson, Hreinn
AU - Williams, Carolyn
AU - Hui, Jennie
AU - Beilby, John
AU - Warrington, Nicole M
AU - James, Alan
AU - Palmer, Lyle J
AU - Koppelman, Gerard H
AU - Heinzmann, Andrea
AU - Krueger, Marcus
AU - Boezen, H Marike
AU - Wheatley, Amanda
AU - Altmuller, Janine
AU - Shin, Hyoung Doo
AU - Uh, Soo-Taek
AU - Cheong, Hyun Sub
AU - Jonsdottir, Brynja
AU - Gislason, David
AU - Park, Choon-Sik
AU - Rasmussen, Linda M
AU - Porsbjerg, Celeste Michala
AU - Hansen, Jakob W
AU - Backer, Vibeke
AU - Werge, Thomas
AU - Janson, Christer
AU - Jönsson, Ulla-Britt
AU - Ng, Maggie C Y
AU - Chan, Juliana
AU - So, Wing Yee
AU - Ma, Ronald
AU - Shah, Svati H
AU - Granger, Christopher B
AU - Quyyumi, Arshed A
AU - Levey, Allan I
AU - Vaccarino, Viola
AU - Reilly, Muredach P
AU - Rader, Daniel J
AU - Williams, Michael J A
AU - van Rij, Andre M
AU - Jones, Gregory T
AU - Trabetti, Elisabetta
AU - Malerba, Giovanni
AU - Pignatti, Pier Franco
AU - Boner, Attilio
AU - Pescollderungg, Lydia
AU - Girelli, Domenico
AU - Olivieri, Oliviero
AU - Martinelli, Nicola
AU - Ludviksson, Bjorn R
AU - Ludviksdottir, Dora
AU - Eyjolfsson, Gudmundur I
AU - Arnar, David
AU - Thorgeirsson, Gudmundur
AU - Deichmann, Klaus
AU - Thompson, Philip J
AU - Wjst, Matthias
AU - Hall, Ian P
AU - Postma, Dirkje S
AU - Gislason, Thorarinn
AU - Gulcher, Jeffrey
AU - Kong, Augustine
AU - Jonsdottir, Ingileif
AU - Thorsteinsdottir, Unnur
AU - Stefansson, Kari
N1 - Keywords: Adaptor Proteins, Vesicular Transport; Algorithms; Asthma; Case-Control Studies; Eosinophils; Eye Proteins; Genes, myb; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Iceland; Interleukins; Leukocyte Count; Myocardial Infarction; Polymorphism, Single Nucleotide; Proteins; Receptors, Cell Surface
PY - 2009
Y1 - 2009
N2 - Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).
AB - Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation of inflammatory responses and thus have important roles in the pathogenesis of inflammatory diseases. Here we describe a genome-wide association scan for sequence variants affecting eosinophil counts in blood of 9,392 Icelanders. The most significant SNPs were studied further in 12,118 Europeans and 5,212 East Asians. SNPs at 2q12 (rs1420101), 2q13 (rs12619285), 3q21 (rs4857855), 5q31 (rs4143832) and 12q24 (rs3184504) reached genome-wide significance (P = 5.3 x 10(-14), 5.4 x 10(-10), 8.6 x 10(-17), 1.2 x 10(-10) and 6.5 x 10(-19), respectively). A SNP at IL1RL1 associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls). SNPs at WDR36, IL33 and MYB that showed suggestive association with eosinophil counts were also associated with atopic asthma (P = 4.2 x 10(-6), 2.2 x 10(-5) and 2.4 x 10(-4), respectively). We also found that a nonsynonymous SNP at 12q24, in SH2B3, associated significantly (P = 8.6 x 10(-8)) with myocardial infarction in six different populations (6,650 cases and 40,621 controls).
U2 - 10.1038/ng.323
DO - 10.1038/ng.323
M3 - Journal article
C2 - 19198610
VL - 41
SP - 342
EP - 347
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 3
ER -
