11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements. / Ettrup, Anders; Mikkelsen, Jens D; Lehel, Szabolcs; Madsen, Jacob; Nielsen, Elsebet Ø; Palner, Mikael; Timmermann, Daniel B; Peters, Dan; Knudsen, Gitte M.

In: Journal of Nuclear Medicine, Vol. 52, No. 9, 2011, p. 1449-56.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Ettrup, A, Mikkelsen, JD, Lehel, S, Madsen, J, Nielsen, EØ, Palner, M, Timmermann, DB, Peters, D & Knudsen, GM 2011, '11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements', Journal of Nuclear Medicine, vol. 52, no. 9, pp. 1449-56. https://doi.org/10.2967/jnumed.111.088815

APA

Ettrup, A., Mikkelsen, J. D., Lehel, S., Madsen, J., Nielsen, E. Ø., Palner, M., Timmermann, D. B., Peters, D., & Knudsen, G. M. (2011). 11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements. Journal of Nuclear Medicine, 52(9), 1449-56. https://doi.org/10.2967/jnumed.111.088815

Vancouver

Ettrup A, Mikkelsen JD, Lehel S, Madsen J, Nielsen EØ, Palner M et al. 11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements. Journal of Nuclear Medicine. 2011;52(9):1449-56. https://doi.org/10.2967/jnumed.111.088815

Author

Ettrup, Anders ; Mikkelsen, Jens D ; Lehel, Szabolcs ; Madsen, Jacob ; Nielsen, Elsebet Ø ; Palner, Mikael ; Timmermann, Daniel B ; Peters, Dan ; Knudsen, Gitte M. / 11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements. In: Journal of Nuclear Medicine. 2011 ; Vol. 52, No. 9. pp. 1449-56.

Bibtex

@article{5c2b5fd4bd6a4cbf98494c24a683e40f,
title = "11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements",
abstract = "Small-molecule a(7) nicotinic acetylcholine receptor (a(7)nAChR) agonists are currently validated for use as treatment for cognitive disturbances in schizophrenia and in Alzheimer disease. A suitable radiolabeled a(7)nAChR PET tracer would be important for in vivo quantification of a(7)nAChR binding in humans and to measure a(7)nAChR occupancy of a(7)nAChR drug candidates. Here, we present the radiosynthesis and in vivo evaluation of (11)C-NS14492 as a selective a(7)nAChR PET radioligand.",
author = "Anders Ettrup and Mikkelsen, {Jens D} and Szabolcs Lehel and Jacob Madsen and Nielsen, {Elsebet {\O}} and Mikael Palner and Timmermann, {Daniel B} and Dan Peters and Knudsen, {Gitte M}",
year = "2011",
doi = "http://dx.doi.org/10.2967/jnumed.111.088815",
language = "English",
volume = "52",
pages = "1449--56",
journal = "The Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine",
number = "9",

}

RIS

TY - JOUR

T1 - 11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements

AU - Ettrup, Anders

AU - Mikkelsen, Jens D

AU - Lehel, Szabolcs

AU - Madsen, Jacob

AU - Nielsen, Elsebet Ø

AU - Palner, Mikael

AU - Timmermann, Daniel B

AU - Peters, Dan

AU - Knudsen, Gitte M

PY - 2011

Y1 - 2011

N2 - Small-molecule a(7) nicotinic acetylcholine receptor (a(7)nAChR) agonists are currently validated for use as treatment for cognitive disturbances in schizophrenia and in Alzheimer disease. A suitable radiolabeled a(7)nAChR PET tracer would be important for in vivo quantification of a(7)nAChR binding in humans and to measure a(7)nAChR occupancy of a(7)nAChR drug candidates. Here, we present the radiosynthesis and in vivo evaluation of (11)C-NS14492 as a selective a(7)nAChR PET radioligand.

AB - Small-molecule a(7) nicotinic acetylcholine receptor (a(7)nAChR) agonists are currently validated for use as treatment for cognitive disturbances in schizophrenia and in Alzheimer disease. A suitable radiolabeled a(7)nAChR PET tracer would be important for in vivo quantification of a(7)nAChR binding in humans and to measure a(7)nAChR occupancy of a(7)nAChR drug candidates. Here, we present the radiosynthesis and in vivo evaluation of (11)C-NS14492 as a selective a(7)nAChR PET radioligand.

U2 - http://dx.doi.org/10.2967/jnumed.111.088815

DO - http://dx.doi.org/10.2967/jnumed.111.088815

M3 - Journal article

VL - 52

SP - 1449

EP - 1456

JO - The Journal of Nuclear Medicine

JF - The Journal of Nuclear Medicine

SN - 0161-5505

IS - 9

ER -

ID: 40216005