5-HTTLPR differentially predicts brain network responses to emotional faces

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

5-HTTLPR differentially predicts brain network responses to emotional faces. / Fisher, Patrick M; Grady, Cheryl L; Madsen, Martin K; Strother, Stephen C; Knudsen, Karen Birgitte Moos.

In: Human Brain Mapping, Vol. 36, No. 7, 07.2015, p. 2842-51.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Fisher, PM, Grady, CL, Madsen, MK, Strother, SC & Knudsen, KBM 2015, '5-HTTLPR differentially predicts brain network responses to emotional faces', Human Brain Mapping, vol. 36, no. 7, pp. 2842-51. https://doi.org/10.1002/hbm.22811

APA

Fisher, P. M., Grady, C. L., Madsen, M. K., Strother, S. C., & Knudsen, K. B. M. (2015). 5-HTTLPR differentially predicts brain network responses to emotional faces. Human Brain Mapping, 36(7), 2842-51. https://doi.org/10.1002/hbm.22811

Vancouver

Fisher PM, Grady CL, Madsen MK, Strother SC, Knudsen KBM. 5-HTTLPR differentially predicts brain network responses to emotional faces. Human Brain Mapping. 2015 Jul;36(7):2842-51. https://doi.org/10.1002/hbm.22811

Author

Fisher, Patrick M ; Grady, Cheryl L ; Madsen, Martin K ; Strother, Stephen C ; Knudsen, Karen Birgitte Moos. / 5-HTTLPR differentially predicts brain network responses to emotional faces. In: Human Brain Mapping. 2015 ; Vol. 36, No. 7. pp. 2842-51.

Bibtex

@article{c2775fb0c67241ff83070313a259f669,
title = "5-HTTLPR differentially predicts brain network responses to emotional faces",
abstract = "The effects of the 5-HTTLPR polymorphism on neural responses to emotionally salient faces have been studied extensively, focusing on amygdala reactivity and amygdala-prefrontal interactions. Despite compelling evidence that emotional face paradigms engage a distributed network of brain regions involved in emotion, cognitive and visual processing, less is known about 5-HTTLPR effects on broader network responses. To address this, we evaluated 5-HTTLPR differences in the whole-brain response to an emotional faces paradigm including neutral, angry and fearful faces using functional magnetic resonance imaging in 76 healthy adults. We observed robust increased response to emotional faces in the amygdala, hippocampus, caudate, fusiform gyrus, superior temporal sulcus and lateral prefrontal and occipito-parietal cortices. We observed dissociation between 5-HTTLPR groups such that LA LA individuals had increased response to only angry faces, relative to neutral ones, but S' carriers had increased activity for both angry and fearful faces relative to neutral. Additionally, the response to angry faces was significantly greater in LA LA individuals compared to S' carriers and the response to fearful faces was significantly greater in S' carriers compared to LA LA individuals. These findings provide novel evidence for emotion-specific 5-HTTLPR effects on the response of a distributed set of brain regions including areas responsive to emotionally salient stimuli and critical components of the face-processing network. These findings provide additional insight into neurobiological mechanisms through which 5-HTTLPR genotype may affect personality and related risk for neuropsychiatric illness.",
keywords = "Adult, Anger, Brain, Facial Expression, Fear, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Polymorphism, Genetic, Serotonin Plasma Membrane Transport Proteins",
author = "Fisher, {Patrick M} and Grady, {Cheryl L} and Madsen, {Martin K} and Strother, {Stephen C} and Knudsen, {Karen Birgitte Moos}",
note = "{\textcopyright} 2015 Wiley Periodicals, Inc.",
year = "2015",
month = jul,
doi = "10.1002/hbm.22811",
language = "English",
volume = "36",
pages = "2842--51",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "JohnWiley & Sons, Inc.",
number = "7",

}

RIS

TY - JOUR

T1 - 5-HTTLPR differentially predicts brain network responses to emotional faces

AU - Fisher, Patrick M

AU - Grady, Cheryl L

AU - Madsen, Martin K

AU - Strother, Stephen C

AU - Knudsen, Karen Birgitte Moos

N1 - © 2015 Wiley Periodicals, Inc.

PY - 2015/7

Y1 - 2015/7

N2 - The effects of the 5-HTTLPR polymorphism on neural responses to emotionally salient faces have been studied extensively, focusing on amygdala reactivity and amygdala-prefrontal interactions. Despite compelling evidence that emotional face paradigms engage a distributed network of brain regions involved in emotion, cognitive and visual processing, less is known about 5-HTTLPR effects on broader network responses. To address this, we evaluated 5-HTTLPR differences in the whole-brain response to an emotional faces paradigm including neutral, angry and fearful faces using functional magnetic resonance imaging in 76 healthy adults. We observed robust increased response to emotional faces in the amygdala, hippocampus, caudate, fusiform gyrus, superior temporal sulcus and lateral prefrontal and occipito-parietal cortices. We observed dissociation between 5-HTTLPR groups such that LA LA individuals had increased response to only angry faces, relative to neutral ones, but S' carriers had increased activity for both angry and fearful faces relative to neutral. Additionally, the response to angry faces was significantly greater in LA LA individuals compared to S' carriers and the response to fearful faces was significantly greater in S' carriers compared to LA LA individuals. These findings provide novel evidence for emotion-specific 5-HTTLPR effects on the response of a distributed set of brain regions including areas responsive to emotionally salient stimuli and critical components of the face-processing network. These findings provide additional insight into neurobiological mechanisms through which 5-HTTLPR genotype may affect personality and related risk for neuropsychiatric illness.

AB - The effects of the 5-HTTLPR polymorphism on neural responses to emotionally salient faces have been studied extensively, focusing on amygdala reactivity and amygdala-prefrontal interactions. Despite compelling evidence that emotional face paradigms engage a distributed network of brain regions involved in emotion, cognitive and visual processing, less is known about 5-HTTLPR effects on broader network responses. To address this, we evaluated 5-HTTLPR differences in the whole-brain response to an emotional faces paradigm including neutral, angry and fearful faces using functional magnetic resonance imaging in 76 healthy adults. We observed robust increased response to emotional faces in the amygdala, hippocampus, caudate, fusiform gyrus, superior temporal sulcus and lateral prefrontal and occipito-parietal cortices. We observed dissociation between 5-HTTLPR groups such that LA LA individuals had increased response to only angry faces, relative to neutral ones, but S' carriers had increased activity for both angry and fearful faces relative to neutral. Additionally, the response to angry faces was significantly greater in LA LA individuals compared to S' carriers and the response to fearful faces was significantly greater in S' carriers compared to LA LA individuals. These findings provide novel evidence for emotion-specific 5-HTTLPR effects on the response of a distributed set of brain regions including areas responsive to emotionally salient stimuli and critical components of the face-processing network. These findings provide additional insight into neurobiological mechanisms through which 5-HTTLPR genotype may affect personality and related risk for neuropsychiatric illness.

KW - Adult

KW - Anger

KW - Brain

KW - Facial Expression

KW - Fear

KW - Female

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Polymorphism, Genetic

KW - Serotonin Plasma Membrane Transport Proteins

U2 - 10.1002/hbm.22811

DO - 10.1002/hbm.22811

M3 - Journal article

C2 - 25929825

VL - 36

SP - 2842

EP - 2851

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 7

ER -

ID: 160056268