A peek into premonitory urges in Tourette syndrome: Temporal evolution of neurophysiological oscillatory signatures
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A peek into premonitory urges in Tourette syndrome : Temporal evolution of neurophysiological oscillatory signatures. / Niccolai, Valentina; Korczok, Silvana; Finis, Jennifer; Jonas, Melanie; Thomalla, Götz; Siebner, Hartwig Roman; Müller-Vahl, Kirsten; Münchau, Alexander; Schnitzler, Alfons; Biermann-Ruben, Katja.
In: Parkinsonism & Related Disorders, Vol. 65, 2019, p. 153-158.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A peek into premonitory urges in Tourette syndrome
T2 - Temporal evolution of neurophysiological oscillatory signatures
AU - Niccolai, Valentina
AU - Korczok, Silvana
AU - Finis, Jennifer
AU - Jonas, Melanie
AU - Thomalla, Götz
AU - Siebner, Hartwig Roman
AU - Müller-Vahl, Kirsten
AU - Münchau, Alexander
AU - Schnitzler, Alfons
AU - Biermann-Ruben, Katja
N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.
PY - 2019
Y1 - 2019
N2 - BACKGROUND: Tics are the core symptom of patients with Gilles de la Tourette syndrome, yet the spatial-temporal dynamics of neural activity causing a tic remains to be determined.OBJECTIVE: Identification of cortical events preceding tic onset.METHODS: In twelve patients with Tourette syndrome we performed magnetoencephalography to trace the time course of beta oscillations (15-30 Hz) in motor cortical areas before tic onset.RESULTS: Patients showed a biphasic modulation of cortical beta activity during the second before tic onset. We observed an initial increase of beta power over the left-hemispheric channels overlying the motor cortex. This increase was subsequently replaced by a decrease in beta power. The beta decrease close to tic onset resembled the typical pattern accompanying preparation of voluntary movements. Only the initial increase in beta power positively correlated with the intensity of motor urges preceding tics.CONCLUSIONS: The spatial-temporal dynamics of cortical activity suggests a voluntary component of tics that might be triggered by a failure of compensatory motor inhibitory mechanisms.
AB - BACKGROUND: Tics are the core symptom of patients with Gilles de la Tourette syndrome, yet the spatial-temporal dynamics of neural activity causing a tic remains to be determined.OBJECTIVE: Identification of cortical events preceding tic onset.METHODS: In twelve patients with Tourette syndrome we performed magnetoencephalography to trace the time course of beta oscillations (15-30 Hz) in motor cortical areas before tic onset.RESULTS: Patients showed a biphasic modulation of cortical beta activity during the second before tic onset. We observed an initial increase of beta power over the left-hemispheric channels overlying the motor cortex. This increase was subsequently replaced by a decrease in beta power. The beta decrease close to tic onset resembled the typical pattern accompanying preparation of voluntary movements. Only the initial increase in beta power positively correlated with the intensity of motor urges preceding tics.CONCLUSIONS: The spatial-temporal dynamics of cortical activity suggests a voluntary component of tics that might be triggered by a failure of compensatory motor inhibitory mechanisms.
U2 - 10.1016/j.parkreldis.2019.05.039
DO - 10.1016/j.parkreldis.2019.05.039
M3 - Journal article
C2 - 31182372
VL - 65
SP - 153
EP - 158
JO - Parkinsonism & Related Disorders
JF - Parkinsonism & Related Disorders
SN - 1353-8020
ER -
ID: 233727468