TY - JOUR

T1 - Altered orbitofrontal sulcogyral patterns in gambling disorder

T2 - a multicenter study

AU - Li, Yansong

AU - Wang, Zixiang

AU - Boileau, Isabelle

AU - Dreher, Jean Claude

AU - Gelskov, Sofie

AU - Genauck, Alexander

AU - Joutsa, Juho

AU - Kaasinen, Valtteri

AU - Perales, José C.

AU - Romanczuk-Seiferth, Nina

AU - Ruiz de Lara, Cristian M.

AU - Siebner, Hartwig R.

AU - van Holst, Ruth J.

AU - van Timmeren, Tim

AU - Sescousse, Guillaume

PY - 2019/8

Y1 - 2019/8

N2 - Gambling disorder is a serious psychiatric condition characterized by decision-making and reward processing impairments that are associated with dysfunctional brain activity in the orbitofrontal cortex (OFC). However, it remains unclear whether OFC functional abnormalities in gambling disorder are accompanied by structural abnormalities. We addressed this question by examining the organization of sulci and gyri in the OFC. This organization is in place very early and stable across life, such that OFC sulcogyral patterns (classified into Types I, II, and III) can be regarded as potential pre-morbid markers of pathological conditions. We gathered structural brain data from nine existing studies, reaching a total of 165 individuals with gambling disorder and 159 healthy controls. Our results, supported by both frequentist and Bayesian statistics, show that the distribution of OFC sulcogyral patterns is skewed in individuals with gambling disorder, with an increased prevalence of Type II pattern compared with healthy controls. Examination of gambling severity did not reveal any significant relationship between OFC sulcogyral patterns and disease severity. Altogether, our results provide evidence for a skewed distribution of OFC sulcogyral patterns in gambling disorder and suggest that pattern Type II might represent a pre-morbid structural brain marker of the disease. It will be important to investigate more closely the functional implications of these structural abnormalities in future work.

AB - Gambling disorder is a serious psychiatric condition characterized by decision-making and reward processing impairments that are associated with dysfunctional brain activity in the orbitofrontal cortex (OFC). However, it remains unclear whether OFC functional abnormalities in gambling disorder are accompanied by structural abnormalities. We addressed this question by examining the organization of sulci and gyri in the OFC. This organization is in place very early and stable across life, such that OFC sulcogyral patterns (classified into Types I, II, and III) can be regarded as potential pre-morbid markers of pathological conditions. We gathered structural brain data from nine existing studies, reaching a total of 165 individuals with gambling disorder and 159 healthy controls. Our results, supported by both frequentist and Bayesian statistics, show that the distribution of OFC sulcogyral patterns is skewed in individuals with gambling disorder, with an increased prevalence of Type II pattern compared with healthy controls. Examination of gambling severity did not reveal any significant relationship between OFC sulcogyral patterns and disease severity. Altogether, our results provide evidence for a skewed distribution of OFC sulcogyral patterns in gambling disorder and suggest that pattern Type II might represent a pre-morbid structural brain marker of the disease. It will be important to investigate more closely the functional implications of these structural abnormalities in future work.

U2 - 10.1038/s41398-019-0520-8

DO - 10.1038/s41398-019-0520-8

M3 - Journal article

C2 - 31383841

AN - SCOPUS:85070223903

VL - 9

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

M1 - 186

ER -