Anterior cingulate serotonin 1B receptor binding is associated with emotional response inhibition
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Anterior cingulate serotonin 1B receptor binding is associated with emotional response inhibition. / da Cunha-Bang, Sofi; Hjordt, Liv Vadskjær; Dam, Vibeke Høyrup; Stenbæk, Dea Siggaard; Sestoft, Dorte; Knudsen, Gitte M.
In: Journal of Psychiatric Research, Vol. 92, 09.2017, p. 199-204.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Anterior cingulate serotonin 1B receptor binding is associated with emotional response inhibition
AU - da Cunha-Bang, Sofi
AU - Hjordt, Liv Vadskjær
AU - Dam, Vibeke Høyrup
AU - Stenbæk, Dea Siggaard
AU - Sestoft, Dorte
AU - Knudsen, Gitte M
N1 - Copyright © 2017. Published by Elsevier Ltd.
PY - 2017/9
Y1 - 2017/9
N2 - Serotonin has a well-established role in emotional processing and is a key neurotransmitter in impulsive aggression, presumably by facilitating response inhibition and regulating subcortical reactivity to aversive stimuli. In this study 44 men, of whom 19 were violent offenders and 25 were non-offender controls, completed an emotional Go/NoGo task requiring inhibition of prepotent motor responses to emotional facial expressions. We also measured cerebral serotonin 1B receptor (5-HT1BR) binding with [11C]AZ10419369 positron emission tomography within regions of the frontal cortex. We hypothesized that 5-HT1BR would be positively associated with false alarms (failures to inhibit nogo responses) in the context of aversive (angry and fearful) facial expressions. Across groups, we found that frontal cortex 5-HT1BR binding was positively correlated with false alarms when angry faces were go stimuli and neutral faces were nogo stimuli (p = 0.05, corrected alpha = 0.0125), but not with false alarms for non-emotional stimuli (failures to inhibit geometric figures). A posthoc analysis revealed the strongest association in anterior cingulate cortex (p = 0.006). In summary, 5-HT1BRs in the anterior cingulate are involved in withholding a prepotent response in the context of angry faces. Our findings suggest that serotonin modulates response inhibition in the context of certain emotional stimuli.
AB - Serotonin has a well-established role in emotional processing and is a key neurotransmitter in impulsive aggression, presumably by facilitating response inhibition and regulating subcortical reactivity to aversive stimuli. In this study 44 men, of whom 19 were violent offenders and 25 were non-offender controls, completed an emotional Go/NoGo task requiring inhibition of prepotent motor responses to emotional facial expressions. We also measured cerebral serotonin 1B receptor (5-HT1BR) binding with [11C]AZ10419369 positron emission tomography within regions of the frontal cortex. We hypothesized that 5-HT1BR would be positively associated with false alarms (failures to inhibit nogo responses) in the context of aversive (angry and fearful) facial expressions. Across groups, we found that frontal cortex 5-HT1BR binding was positively correlated with false alarms when angry faces were go stimuli and neutral faces were nogo stimuli (p = 0.05, corrected alpha = 0.0125), but not with false alarms for non-emotional stimuli (failures to inhibit geometric figures). A posthoc analysis revealed the strongest association in anterior cingulate cortex (p = 0.006). In summary, 5-HT1BRs in the anterior cingulate are involved in withholding a prepotent response in the context of angry faces. Our findings suggest that serotonin modulates response inhibition in the context of certain emotional stimuli.
KW - Adamantane/analogs & derivatives
KW - Adult
KW - Aminoquinolines/pharmacokinetics
KW - Emotions
KW - Gyrus Cinguli/diagnostic imaging
KW - Humans
KW - Image Processing, Computer-Assisted
KW - Iodine Isotopes/pharmacokinetics
KW - Magnetic Resonance Imaging
KW - Male
KW - Neuropsychological Tests
KW - Personality Disorders/diagnostic imaging
KW - Photic Stimulation
KW - Positron-Emission Tomography
KW - Protein Binding/physiology
KW - Receptor, Serotonin, 5-HT1B/metabolism
KW - Violence/psychology
KW - Young Adult
U2 - 10.1016/j.jpsychires.2017.05.003
DO - 10.1016/j.jpsychires.2017.05.003
M3 - Journal article
C2 - 28502766
VL - 92
SP - 199
EP - 204
JO - Journal of Psychiatric Research
JF - Journal of Psychiatric Research
SN - 0022-3956
ER -
ID: 360344949