Association of childhood trauma with cognitive impairment and structural brain alterations in remitted patients with bipolar disorder
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Association of childhood trauma with cognitive impairment and structural brain alterations in remitted patients with bipolar disorder. / Jørgensen, Josefine Lærke; Macoveanu, Julian; Petersen, Jeff Zarp; Knudsen, Gitte Moos; Kessing, Lars Vedel; Jørgensen, Martin Balslev; Miskowiak, Kamilla Woznica.
In: Journal of Affective Disorders, Vol. 337, 2023, p. 75-85.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Association of childhood trauma with cognitive impairment and structural brain alterations in remitted patients with bipolar disorder
AU - Jørgensen, Josefine Lærke
AU - Macoveanu, Julian
AU - Petersen, Jeff Zarp
AU - Knudsen, Gitte Moos
AU - Kessing, Lars Vedel
AU - Jørgensen, Martin Balslev
AU - Miskowiak, Kamilla Woznica
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Background: Cognitive impairment affects many patients with bipolar disorder (BD). No pro-cognitive treatment with robust efficacy exists partly due to limited insight into underlying neurobiological abnormalities. Methods: This magnetic resonance imaging (MRI) study investigates structural neuronal correlates of cognitive impairment in BD by comparing brain measures in a large sample of cognitively impaired versus cognitively intact patients with BD or cognitively impaired patients with major depressive disorder (MDD) and healthy controls (HC). Participants underwent neuropsychological assessments and MRI scans. The cognitively impaired and – intact BD and MDD patient groups were compared with each other and HC regarding prefrontal cortex measures, hippocampus shape/volume, and total cerebral white (WM) and grey matter (GM). Results: Cognitively impaired BD patients showed lower total cerebral WM volume than HC, which scaled with poorer global cognitive performance and more childhood trauma. Cognitively impaired BD patients also showed lower adjusted GM volume and thickness in the frontopolar cortex than HC but greater adjusted GM volume in the temporal cortex than cognitively normal BD patients. Cognitively impaired BD patients showed decreased cingulate volume than cognitively impaired MDD patients. Hippocampal measures were similar across all groups. Limitations: The cross-sectional study design prevented insights into causal relationships. Conclusions: Lower total cerebral WM and regional frontopolar and temporal GM abnormalities may constitute structural neuronal correlates of cognitive impairment in BD, of which the WM deficits scale with the degree of childhood trauma. The results deepen the understanding of cognitive impairment in BD and provide a neuronal target for pro-cognitive treatment development.
AB - Background: Cognitive impairment affects many patients with bipolar disorder (BD). No pro-cognitive treatment with robust efficacy exists partly due to limited insight into underlying neurobiological abnormalities. Methods: This magnetic resonance imaging (MRI) study investigates structural neuronal correlates of cognitive impairment in BD by comparing brain measures in a large sample of cognitively impaired versus cognitively intact patients with BD or cognitively impaired patients with major depressive disorder (MDD) and healthy controls (HC). Participants underwent neuropsychological assessments and MRI scans. The cognitively impaired and – intact BD and MDD patient groups were compared with each other and HC regarding prefrontal cortex measures, hippocampus shape/volume, and total cerebral white (WM) and grey matter (GM). Results: Cognitively impaired BD patients showed lower total cerebral WM volume than HC, which scaled with poorer global cognitive performance and more childhood trauma. Cognitively impaired BD patients also showed lower adjusted GM volume and thickness in the frontopolar cortex than HC but greater adjusted GM volume in the temporal cortex than cognitively normal BD patients. Cognitively impaired BD patients showed decreased cingulate volume than cognitively impaired MDD patients. Hippocampal measures were similar across all groups. Limitations: The cross-sectional study design prevented insights into causal relationships. Conclusions: Lower total cerebral WM and regional frontopolar and temporal GM abnormalities may constitute structural neuronal correlates of cognitive impairment in BD, of which the WM deficits scale with the degree of childhood trauma. The results deepen the understanding of cognitive impairment in BD and provide a neuronal target for pro-cognitive treatment development.
KW - Bipolar disorder
KW - Childhood trauma
KW - Cognitive impairment
KW - Grey matter abnormalities
KW - Magnetic resonance imaging
KW - White matter
UR - http://www.scopus.com/inward/record.url?scp=85160420974&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2023.05.078
DO - 10.1016/j.jad.2023.05.078
M3 - Journal article
C2 - 37236273
AN - SCOPUS:85160420974
VL - 337
SP - 75
EP - 85
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -
ID: 370732626