Associations between aberrant working memory-related neural activity and cognitive impairments in somatically healthy, remitted patients with mood disorders
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Associations between aberrant working memory-related neural activity and cognitive impairments in somatically healthy, remitted patients with mood disorders. / Macoveanu, Julian; Petersen, Jeff Zarp; Fisher, Patrick M.; Kessing, Lars Vedel; Knudsen, Gitte Moos; Miskowiak, Kamilla Woznica.
In: Psychological Medicine, Vol. 53, No. 15, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Associations between aberrant working memory-related neural activity and cognitive impairments in somatically healthy, remitted patients with mood disorders
AU - Macoveanu, Julian
AU - Petersen, Jeff Zarp
AU - Fisher, Patrick M.
AU - Kessing, Lars Vedel
AU - Knudsen, Gitte Moos
AU - Miskowiak, Kamilla Woznica
PY - 2023
Y1 - 2023
N2 - BackgroundPersistent cognitive deficits are prevalent in patients with bipolar disorder (BD) and unipolar disorder (UD), but treatments effectively targeting cognition in these mood disorders are lacking. This is partly due to poor insight into the neuronal underpinnings of cognitive deficits.MethodsThe aim of this functional magnetic resonance imaging (fMRI) study was to investigate the neuronal underpinnings of working memory (WM)-related deficits in somatically healthy, remitted patients with BD or UD (n = 66) with cognitive and functional impairments compared to 38 healthy controls (HC). The participants underwent neuropsychological testing and fMRI, while performing a visuospatial and a verbal N-back WM paradigm.ResultsRelative to HC, patients exhibited hypo-activity across dorsolateral prefrontal cortex as well as frontal and parietal nodes of the cognitive control network (CCN) and hyper-activity in left orbitofrontal cortex within the default mode network (DMN) during both visuospatial and verbal WM performance. Verbal WM-related response in the left posterior superior frontal gyrus (SFG) within CCN was lower in patients and correlated positively with out-of-scanner executive function performance across all participants.ConclusionsOur findings suggest that cognitive impairments across BD and UD are associated with insufficient recruitment of task-relevant regions in the CCN and down-regulation of task-irrelevant orbitofrontal activity within the DMN during task performance. Specifically, a lower recruitment of the left posterior SFG within CCN during verbal WM was associated with lower cognitive performance.
AB - BackgroundPersistent cognitive deficits are prevalent in patients with bipolar disorder (BD) and unipolar disorder (UD), but treatments effectively targeting cognition in these mood disorders are lacking. This is partly due to poor insight into the neuronal underpinnings of cognitive deficits.MethodsThe aim of this functional magnetic resonance imaging (fMRI) study was to investigate the neuronal underpinnings of working memory (WM)-related deficits in somatically healthy, remitted patients with BD or UD (n = 66) with cognitive and functional impairments compared to 38 healthy controls (HC). The participants underwent neuropsychological testing and fMRI, while performing a visuospatial and a verbal N-back WM paradigm.ResultsRelative to HC, patients exhibited hypo-activity across dorsolateral prefrontal cortex as well as frontal and parietal nodes of the cognitive control network (CCN) and hyper-activity in left orbitofrontal cortex within the default mode network (DMN) during both visuospatial and verbal WM performance. Verbal WM-related response in the left posterior superior frontal gyrus (SFG) within CCN was lower in patients and correlated positively with out-of-scanner executive function performance across all participants.ConclusionsOur findings suggest that cognitive impairments across BD and UD are associated with insufficient recruitment of task-relevant regions in the CCN and down-regulation of task-irrelevant orbitofrontal activity within the DMN during task performance. Specifically, a lower recruitment of the left posterior SFG within CCN during verbal WM was associated with lower cognitive performance.
KW - Bipolar disorder
KW - cognitive impairment
KW - depression
KW - fMRI
U2 - 10.1017/S0033291723000715
DO - 10.1017/S0033291723000715
M3 - Journal article
C2 - 37051904
VL - 53
JO - Psychological Medicine
JF - Psychological Medicine
SN - 0033-2917
IS - 15
ER -
ID: 346254455