Associative stimulation of the supraorbital nerve fails to induce timing-specific plasticity in the human blink reflex

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Associative stimulation of the supraorbital nerve fails to induce timing-specific plasticity in the human blink reflex. / Zeuner, Kirsten E; Knutzen, Arne; Al-Ali, Asmaa; Hallett, Mark; Deuschl, Günther; Bergmann, Til O; Siebner, Hartwig R.

In: P L o S One, Vol. 5, No. 10, 01.01.2010, p. e13602.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Zeuner, KE, Knutzen, A, Al-Ali, A, Hallett, M, Deuschl, G, Bergmann, TO & Siebner, HR 2010, 'Associative stimulation of the supraorbital nerve fails to induce timing-specific plasticity in the human blink reflex', P L o S One, vol. 5, no. 10, pp. e13602. https://doi.org/10.1371/journal.pone.0013602

APA

Zeuner, K. E., Knutzen, A., Al-Ali, A., Hallett, M., Deuschl, G., Bergmann, T. O., & Siebner, H. R. (2010). Associative stimulation of the supraorbital nerve fails to induce timing-specific plasticity in the human blink reflex. P L o S One, 5(10), e13602. https://doi.org/10.1371/journal.pone.0013602

Vancouver

Zeuner KE, Knutzen A, Al-Ali A, Hallett M, Deuschl G, Bergmann TO et al. Associative stimulation of the supraorbital nerve fails to induce timing-specific plasticity in the human blink reflex. P L o S One. 2010 Jan 1;5(10):e13602. https://doi.org/10.1371/journal.pone.0013602

Author

Zeuner, Kirsten E ; Knutzen, Arne ; Al-Ali, Asmaa ; Hallett, Mark ; Deuschl, Günther ; Bergmann, Til O ; Siebner, Hartwig R. / Associative stimulation of the supraorbital nerve fails to induce timing-specific plasticity in the human blink reflex. In: P L o S One. 2010 ; Vol. 5, No. 10. pp. e13602.

Bibtex

@article{50215ebc21374f02aed79e9ec8484e5e,
title = "Associative stimulation of the supraorbital nerve fails to induce timing-specific plasticity in the human blink reflex",
abstract = "Associative high-frequency electrical stimulation (HFS) of the supraorbital nerve in five healthy individuals induced long-term potentiation (LTP)-like or depression (LTD)-like changes in the human blink reflex circuit according to the rules of spike timing-dependent plasticity (Mao and Evinger, 2001). HFS given at the onset of the R2 component of the blink reflex (HFS(LTP)) produced a lasting facilitation of the R2, whereas HFS given shortly before R2 (HFS(LTD)) caused a lasting suppression of the R2. In patients with benign essential blepharospasm (BEB), a focal dystonia affecting the orbicularis oculi muscles, HFS(LTP) induced excessive LTP-like associative plasticity relative to healthy controls, which was normalized after botulinum toxin (BTX) injections (Quartarone et al, 2006).",
keywords = "Adult, Blinking, Case-Control Studies, Electric Stimulation, Female, Humans, Male, Middle Aged, Neuronal Plasticity, Reflex",
author = "Zeuner, {Kirsten E} and Arne Knutzen and Asmaa Al-Ali and Mark Hallett and G{\"u}nther Deuschl and Bergmann, {Til O} and Siebner, {Hartwig R}",
year = "2010",
month = jan,
day = "1",
doi = "10.1371/journal.pone.0013602",
language = "English",
volume = "5",
pages = "e13602",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

RIS

TY - JOUR

T1 - Associative stimulation of the supraorbital nerve fails to induce timing-specific plasticity in the human blink reflex

AU - Zeuner, Kirsten E

AU - Knutzen, Arne

AU - Al-Ali, Asmaa

AU - Hallett, Mark

AU - Deuschl, Günther

AU - Bergmann, Til O

AU - Siebner, Hartwig R

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Associative high-frequency electrical stimulation (HFS) of the supraorbital nerve in five healthy individuals induced long-term potentiation (LTP)-like or depression (LTD)-like changes in the human blink reflex circuit according to the rules of spike timing-dependent plasticity (Mao and Evinger, 2001). HFS given at the onset of the R2 component of the blink reflex (HFS(LTP)) produced a lasting facilitation of the R2, whereas HFS given shortly before R2 (HFS(LTD)) caused a lasting suppression of the R2. In patients with benign essential blepharospasm (BEB), a focal dystonia affecting the orbicularis oculi muscles, HFS(LTP) induced excessive LTP-like associative plasticity relative to healthy controls, which was normalized after botulinum toxin (BTX) injections (Quartarone et al, 2006).

AB - Associative high-frequency electrical stimulation (HFS) of the supraorbital nerve in five healthy individuals induced long-term potentiation (LTP)-like or depression (LTD)-like changes in the human blink reflex circuit according to the rules of spike timing-dependent plasticity (Mao and Evinger, 2001). HFS given at the onset of the R2 component of the blink reflex (HFS(LTP)) produced a lasting facilitation of the R2, whereas HFS given shortly before R2 (HFS(LTD)) caused a lasting suppression of the R2. In patients with benign essential blepharospasm (BEB), a focal dystonia affecting the orbicularis oculi muscles, HFS(LTP) induced excessive LTP-like associative plasticity relative to healthy controls, which was normalized after botulinum toxin (BTX) injections (Quartarone et al, 2006).

KW - Adult

KW - Blinking

KW - Case-Control Studies

KW - Electric Stimulation

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Neuronal Plasticity

KW - Reflex

U2 - 10.1371/journal.pone.0013602

DO - 10.1371/journal.pone.0013602

M3 - Journal article

C2 - 21049057

VL - 5

SP - e13602

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 10

ER -

ID: 33437863