Brain extraction and distribution of 99mTc-bicisate in humans and in rats

Research output: Contribution to journalJournal articleResearchpeer-review

Standard

Brain extraction and distribution of 99mTc-bicisate in humans and in rats. / Knudsen, G M; Andersen, A R; Somnier, F E; Videbaek, C; Hasselbalch, S; Paulson, O B.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 14, No. Suppl 1, 01.1994, p. S12-8.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Knudsen, GM, Andersen, AR, Somnier, FE, Videbaek, C, Hasselbalch, S & Paulson, OB 1994, 'Brain extraction and distribution of 99mTc-bicisate in humans and in rats', Journal of Cerebral Blood Flow and Metabolism, vol. 14, no. Suppl 1, pp. S12-8.

APA

Knudsen, G. M., Andersen, A. R., Somnier, F. E., Videbaek, C., Hasselbalch, S., & Paulson, O. B. (1994). Brain extraction and distribution of 99mTc-bicisate in humans and in rats. Journal of Cerebral Blood Flow and Metabolism, 14(Suppl 1), S12-8.

Vancouver

Knudsen GM, Andersen AR, Somnier FE, Videbaek C, Hasselbalch S, Paulson OB. Brain extraction and distribution of 99mTc-bicisate in humans and in rats. Journal of Cerebral Blood Flow and Metabolism. 1994 Jan;14(Suppl 1):S12-8.

Author

Knudsen, G M ; Andersen, A R ; Somnier, F E ; Videbaek, C ; Hasselbalch, S ; Paulson, O B. / Brain extraction and distribution of 99mTc-bicisate in humans and in rats. In: Journal of Cerebral Blood Flow and Metabolism. 1994 ; Vol. 14, No. Suppl 1. pp. S12-8.

Bibtex

@article{260afd5d1a9a4db187e3e432ad1653b2,
title = "Brain extraction and distribution of 99mTc-bicisate in humans and in rats",
abstract = "Blood-brain barrier (BBB) passage of the flow tracer ethylenediylbis-L-cystein diethylester (bicisate, ECD) was measured repeatedly in five patients by means of the intravenous (i.v.) double-indicator technique using 24Na+ as an intravascular cotracer. After i.v. injection, the arterial concentration curve of 99mTc-bicisate was delayed and dispersed compared with that of the intravascular cotracer, presumably due to lung retention of the flow tracer. The corrected cerebral venous output curves were fitted using a three-compartment model with four parameters. At resting cerebral blood flow (CBF) values, the unidirectional brain extraction was 0.57 +/- 0.05, the permeability-surface area product for passage from blood to brain (PS1) was 0.48 +/- 0.07 ml/g/min, and the distribution volume for bicisate was 0.74 +/- 0.20 (mean +/- SD). In a single patient, BBB transport after i.v. injection of bicisate was compared with that of a similar flow tracer, d,l-hexamethylpropyleneamine oxime (HM-PAO), and similar values were found for the two tracers. In 19 rats, the brain extraction of bicisate was measured by means of the intracarotid double-indicator technique. The brain extraction was measured at resting, decreased, and increased CBF values. Low CBF values were obtained by hyperventilation and high values by hypercapnia. The degree of backflux of tracer from brain to blood was evaluated by means of the three-compartment model and was found to be negligible in these experiments. The brain extraction was 0.70 +/- 0.1 and PS1 was 0.94 +/- 0.27 ml/g/min. During hypercapnia, CBF increased from 0.77 to 1.09 ml/g/min, leading to a significant decrease in brain extraction, from 0.70 to 0.56.(ABSTRACT TRUNCATED AT 250 WORDS)",
keywords = "Adult, Animals, Arteries, Biological Transport, Blood-Brain Barrier, Brain/metabolism, Cerebrovascular Circulation, Cysteine/analogs & derivatives, Female, Humans, Male, Middle Aged, Organotechnetium Compounds/blood, Oximes/pharmacokinetics, Rats, Rats, Wistar, Sodium Radioisotopes, Tissue Distribution, Veins",
author = "Knudsen, {G M} and Andersen, {A R} and Somnier, {F E} and C Videbaek and S Hasselbalch and Paulson, {O B}",
year = "1994",
month = jan,
language = "English",
volume = "14",
pages = "S12--8",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "Suppl 1",

}

RIS

TY - JOUR

T1 - Brain extraction and distribution of 99mTc-bicisate in humans and in rats

AU - Knudsen, G M

AU - Andersen, A R

AU - Somnier, F E

AU - Videbaek, C

AU - Hasselbalch, S

AU - Paulson, O B

PY - 1994/1

Y1 - 1994/1

N2 - Blood-brain barrier (BBB) passage of the flow tracer ethylenediylbis-L-cystein diethylester (bicisate, ECD) was measured repeatedly in five patients by means of the intravenous (i.v.) double-indicator technique using 24Na+ as an intravascular cotracer. After i.v. injection, the arterial concentration curve of 99mTc-bicisate was delayed and dispersed compared with that of the intravascular cotracer, presumably due to lung retention of the flow tracer. The corrected cerebral venous output curves were fitted using a three-compartment model with four parameters. At resting cerebral blood flow (CBF) values, the unidirectional brain extraction was 0.57 +/- 0.05, the permeability-surface area product for passage from blood to brain (PS1) was 0.48 +/- 0.07 ml/g/min, and the distribution volume for bicisate was 0.74 +/- 0.20 (mean +/- SD). In a single patient, BBB transport after i.v. injection of bicisate was compared with that of a similar flow tracer, d,l-hexamethylpropyleneamine oxime (HM-PAO), and similar values were found for the two tracers. In 19 rats, the brain extraction of bicisate was measured by means of the intracarotid double-indicator technique. The brain extraction was measured at resting, decreased, and increased CBF values. Low CBF values were obtained by hyperventilation and high values by hypercapnia. The degree of backflux of tracer from brain to blood was evaluated by means of the three-compartment model and was found to be negligible in these experiments. The brain extraction was 0.70 +/- 0.1 and PS1 was 0.94 +/- 0.27 ml/g/min. During hypercapnia, CBF increased from 0.77 to 1.09 ml/g/min, leading to a significant decrease in brain extraction, from 0.70 to 0.56.(ABSTRACT TRUNCATED AT 250 WORDS)

AB - Blood-brain barrier (BBB) passage of the flow tracer ethylenediylbis-L-cystein diethylester (bicisate, ECD) was measured repeatedly in five patients by means of the intravenous (i.v.) double-indicator technique using 24Na+ as an intravascular cotracer. After i.v. injection, the arterial concentration curve of 99mTc-bicisate was delayed and dispersed compared with that of the intravascular cotracer, presumably due to lung retention of the flow tracer. The corrected cerebral venous output curves were fitted using a three-compartment model with four parameters. At resting cerebral blood flow (CBF) values, the unidirectional brain extraction was 0.57 +/- 0.05, the permeability-surface area product for passage from blood to brain (PS1) was 0.48 +/- 0.07 ml/g/min, and the distribution volume for bicisate was 0.74 +/- 0.20 (mean +/- SD). In a single patient, BBB transport after i.v. injection of bicisate was compared with that of a similar flow tracer, d,l-hexamethylpropyleneamine oxime (HM-PAO), and similar values were found for the two tracers. In 19 rats, the brain extraction of bicisate was measured by means of the intracarotid double-indicator technique. The brain extraction was measured at resting, decreased, and increased CBF values. Low CBF values were obtained by hyperventilation and high values by hypercapnia. The degree of backflux of tracer from brain to blood was evaluated by means of the three-compartment model and was found to be negligible in these experiments. The brain extraction was 0.70 +/- 0.1 and PS1 was 0.94 +/- 0.27 ml/g/min. During hypercapnia, CBF increased from 0.77 to 1.09 ml/g/min, leading to a significant decrease in brain extraction, from 0.70 to 0.56.(ABSTRACT TRUNCATED AT 250 WORDS)

KW - Adult

KW - Animals

KW - Arteries

KW - Biological Transport

KW - Blood-Brain Barrier

KW - Brain/metabolism

KW - Cerebrovascular Circulation

KW - Cysteine/analogs & derivatives

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Organotechnetium Compounds/blood

KW - Oximes/pharmacokinetics

KW - Rats

KW - Rats, Wistar

KW - Sodium Radioisotopes

KW - Tissue Distribution

KW - Veins

M3 - Journal article

C2 - 8263066

VL - 14

SP - S12-8

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - Suppl 1

ER -

ID: 279847380