Bright-light intervention induces a dose-dependent increase in striatal response to risk in healthy volunteers
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Bright-light intervention induces a dose-dependent increase in striatal response to risk in healthy volunteers. / Macoveanu, Julian; Fisher, Patrick M; Madsen, Martin K; Mc Mahon, Brenda; Knudsen, Gitte M; Siebner, Hartwig R.
In: NeuroImage, Vol. 139, 2016, p. 37-43.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Bright-light intervention induces a dose-dependent increase in striatal response to risk in healthy volunteers
AU - Macoveanu, Julian
AU - Fisher, Patrick M
AU - Madsen, Martin K
AU - Mc Mahon, Brenda
AU - Knudsen, Gitte M
AU - Siebner, Hartwig R
N1 - Copyright © 2016 Elsevier Inc. All rights reserved.
PY - 2016
Y1 - 2016
N2 - Bright-light interventions have successfully been used to reduce depression symptoms in patients with seasonal affective disorder, a depressive disorder most frequently occurring during seasons with reduced daylight availability. Yet, little is known about how light exposure impacts human brain function, for instance on risk taking, a process affected in depressive disorders. Here we examined the modulatory effects of bright-light exposure on brain activity during a risk-taking task. Thirty-two healthy male volunteers living in the greater Copenhagen area received 3weeks of bright-light intervention during the winter season. Adopting a double-blinded dose-response design, bright-light was applied for 30minutes continuously every morning. The individual dose varied between 100 and 11.000lx. Whole-brain functional MRI was performed before and after bright-light intervention to probe how the intervention modifies risk-taking related neural activity during a two-choice gambling task. We also assessed whether inter-individual differences in the serotonin transporter-linked polymorphic region (5-HTTLPR) genotype influenced the effects of bright-light intervention on risk processing. Bright-light intervention led to a dose-dependent increase in risk-taking in the LA/LA group relative to the non-LA/LA group. Further, bright-light intervention enhanced risk-related activity in ventral striatum and head of caudate nucleus in proportion with the individual bright-light dose. The augmentation effect of light exposure on striatal risk processing was not influenced by the 5-HTTLPR-genotype. This study provides novel evidence that in healthy non-depressive individuals bright-light intervention increases striatal processing to risk in a dose-dependent fashion. The findings provide converging evidence that risk processing is sensitive to bright-light exposure during winter.
AB - Bright-light interventions have successfully been used to reduce depression symptoms in patients with seasonal affective disorder, a depressive disorder most frequently occurring during seasons with reduced daylight availability. Yet, little is known about how light exposure impacts human brain function, for instance on risk taking, a process affected in depressive disorders. Here we examined the modulatory effects of bright-light exposure on brain activity during a risk-taking task. Thirty-two healthy male volunteers living in the greater Copenhagen area received 3weeks of bright-light intervention during the winter season. Adopting a double-blinded dose-response design, bright-light was applied for 30minutes continuously every morning. The individual dose varied between 100 and 11.000lx. Whole-brain functional MRI was performed before and after bright-light intervention to probe how the intervention modifies risk-taking related neural activity during a two-choice gambling task. We also assessed whether inter-individual differences in the serotonin transporter-linked polymorphic region (5-HTTLPR) genotype influenced the effects of bright-light intervention on risk processing. Bright-light intervention led to a dose-dependent increase in risk-taking in the LA/LA group relative to the non-LA/LA group. Further, bright-light intervention enhanced risk-related activity in ventral striatum and head of caudate nucleus in proportion with the individual bright-light dose. The augmentation effect of light exposure on striatal risk processing was not influenced by the 5-HTTLPR-genotype. This study provides novel evidence that in healthy non-depressive individuals bright-light intervention increases striatal processing to risk in a dose-dependent fashion. The findings provide converging evidence that risk processing is sensitive to bright-light exposure during winter.
KW - Journal Article
U2 - 10.1016/j.neuroimage.2016.06.024
DO - 10.1016/j.neuroimage.2016.06.024
M3 - Journal article
C2 - 27318214
VL - 139
SP - 37
EP - 43
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
ER -
ID: 177096651