Calcitonin gene-related peptide modulates heat nociception in the human brain - An fMRI study in healthy volunteers

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Calcitonin gene-related peptide modulates heat nociception in the human brain - An fMRI study in healthy volunteers. / Asghar, Mohammad Sohail; Becerra, Lino; Larsson, Henrik B.W.; Borsook, David; Ashina, Messoud.

In: PLoS ONE, Vol. 11, No. 3, e0150334, 2016, p. 1-20.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Asghar, MS, Becerra, L, Larsson, HBW, Borsook, D & Ashina, M 2016, 'Calcitonin gene-related peptide modulates heat nociception in the human brain - An fMRI study in healthy volunteers', PLoS ONE, vol. 11, no. 3, e0150334, pp. 1-20. https://doi.org/10.1371/journal.pone.0150334

APA

Asghar, M. S., Becerra, L., Larsson, H. B. W., Borsook, D., & Ashina, M. (2016). Calcitonin gene-related peptide modulates heat nociception in the human brain - An fMRI study in healthy volunteers. PLoS ONE, 11(3), 1-20. [e0150334]. https://doi.org/10.1371/journal.pone.0150334

Vancouver

Asghar MS, Becerra L, Larsson HBW, Borsook D, Ashina M. Calcitonin gene-related peptide modulates heat nociception in the human brain - An fMRI study in healthy volunteers. PLoS ONE. 2016;11(3):1-20. e0150334. https://doi.org/10.1371/journal.pone.0150334

Author

Asghar, Mohammad Sohail ; Becerra, Lino ; Larsson, Henrik B.W. ; Borsook, David ; Ashina, Messoud. / Calcitonin gene-related peptide modulates heat nociception in the human brain - An fMRI study in healthy volunteers. In: PLoS ONE. 2016 ; Vol. 11, No. 3. pp. 1-20.

Bibtex

@article{f852211b1de642f2816a5fb08613a0ad,
title = "Calcitonin gene-related peptide modulates heat nociception in the human brain - An fMRI study in healthy volunteers",
abstract = "Background: Intravenous infusion of calcitonin-gene-related-peptide (CGRP) provokes headache and migraine in humans. Mechanisms underlying CGRP-induced headache are not fully clarified and it is unknown to what extent CGRP modulates nociceptive processing in the brain. To elucidate this we recorded blood-oxygenation-level-dependent (BOLD) signals in the brain by functional MRI after infusion of CGRP in a double-blind placebo-controlled crossover study of 27 healthy volunteers. BOLD-signals were recorded in response to noxious heat stimuli in the V1-area of the trigeminal nerve. In addition, we measured BOLD-signals after injection of sumatriptan (5-HT1B/1D antagonist). Results: Brain activation to noxious heat stimuli following CGRP infusion compared to baseline resulted in increased BOLD-signal in insula and brainstem, and decreased BOLD-signal in the caudate nuclei, thalamus and cingulate cortex. Sumatriptan injection reversed these changes. Conclusion: The changes in BOLD-signals in the brain after CGRP infusion suggests that systemic CGRP modulates nociceptive transmission in the trigeminal pain pathways in response to noxious heat stimuli.",
author = "Asghar, {Mohammad Sohail} and Lino Becerra and Larsson, {Henrik B.W.} and David Borsook and Messoud Ashina",
year = "2016",
doi = "10.1371/journal.pone.0150334",
language = "English",
volume = "11",
pages = "1--20",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - Calcitonin gene-related peptide modulates heat nociception in the human brain - An fMRI study in healthy volunteers

AU - Asghar, Mohammad Sohail

AU - Becerra, Lino

AU - Larsson, Henrik B.W.

AU - Borsook, David

AU - Ashina, Messoud

PY - 2016

Y1 - 2016

N2 - Background: Intravenous infusion of calcitonin-gene-related-peptide (CGRP) provokes headache and migraine in humans. Mechanisms underlying CGRP-induced headache are not fully clarified and it is unknown to what extent CGRP modulates nociceptive processing in the brain. To elucidate this we recorded blood-oxygenation-level-dependent (BOLD) signals in the brain by functional MRI after infusion of CGRP in a double-blind placebo-controlled crossover study of 27 healthy volunteers. BOLD-signals were recorded in response to noxious heat stimuli in the V1-area of the trigeminal nerve. In addition, we measured BOLD-signals after injection of sumatriptan (5-HT1B/1D antagonist). Results: Brain activation to noxious heat stimuli following CGRP infusion compared to baseline resulted in increased BOLD-signal in insula and brainstem, and decreased BOLD-signal in the caudate nuclei, thalamus and cingulate cortex. Sumatriptan injection reversed these changes. Conclusion: The changes in BOLD-signals in the brain after CGRP infusion suggests that systemic CGRP modulates nociceptive transmission in the trigeminal pain pathways in response to noxious heat stimuli.

AB - Background: Intravenous infusion of calcitonin-gene-related-peptide (CGRP) provokes headache and migraine in humans. Mechanisms underlying CGRP-induced headache are not fully clarified and it is unknown to what extent CGRP modulates nociceptive processing in the brain. To elucidate this we recorded blood-oxygenation-level-dependent (BOLD) signals in the brain by functional MRI after infusion of CGRP in a double-blind placebo-controlled crossover study of 27 healthy volunteers. BOLD-signals were recorded in response to noxious heat stimuli in the V1-area of the trigeminal nerve. In addition, we measured BOLD-signals after injection of sumatriptan (5-HT1B/1D antagonist). Results: Brain activation to noxious heat stimuli following CGRP infusion compared to baseline resulted in increased BOLD-signal in insula and brainstem, and decreased BOLD-signal in the caudate nuclei, thalamus and cingulate cortex. Sumatriptan injection reversed these changes. Conclusion: The changes in BOLD-signals in the brain after CGRP infusion suggests that systemic CGRP modulates nociceptive transmission in the trigeminal pain pathways in response to noxious heat stimuli.

U2 - 10.1371/journal.pone.0150334

DO - 10.1371/journal.pone.0150334

M3 - Journal article

C2 - 26990646

AN - SCOPUS:84962159469

VL - 11

SP - 1

EP - 20

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 3

M1 - e0150334

ER -

ID: 178884886