Can DMCO Detect Visual Field Loss in Neurological Patients? A Secondary Validation Study
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Can DMCO Detect Visual Field Loss in Neurological Patients? A Secondary Validation Study. / Olsen, Ane Sophie; Steensberg, Alvilda Thougaard; la Cour, Morten; Kjaer, Troels Wesenberg; Damato, Bertil; Pinborg, Lars Hageman; Kolko, Miriam.
In: Ophthalmic Research, Vol. 58, No. 2, 2017, p. 85-93.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Can DMCO Detect Visual Field Loss in Neurological Patients? A Secondary Validation Study
AU - Olsen, Ane Sophie
AU - Steensberg, Alvilda Thougaard
AU - la Cour, Morten
AU - Kjaer, Troels Wesenberg
AU - Damato, Bertil
AU - Pinborg, Lars Hageman
AU - Kolko, Miriam
PY - 2017
Y1 - 2017
N2 - Unrecognized visual field loss is caused by a range of blinding eye conditions as well as serious brain diseases. The commonest cause of asymptomatic visual field loss is glaucoma. No screening tools have been proven cost-effective. Damato Multifixation Campimetry Online (DMCO), an inexpensive online test, has been evaluated as a future cost-beneficial tool to detect glaucoma. To further validate DMCO, this study aimed to test DMCO in a preselected population with neurological visual field loss. Methods: The study design was an evaluation of a diagnostic test. Patients were included if they had undergone surgery for epilepsy during 2011-2014, resulting in visual field loss. They were examined with DMCO and results were compared with those obtained with the Humphrey Field Analyzer (30:2 SITA-Fast). DMCO sensitivity and specificity were estimated with 95% confidence intervals. Results: The cohort comprised 40 patients (25 female and 15 male) with a mean age of 39 years (range 17-60 years). The mean visual acuity was >1.0 and all eyes had an intraocular pressure <21 mm Hg. Sensitivity and specificity of DMCO compared to the reference standard were 72.7 and 96.3%, respectively. Conclusions: DMCO detects moderate-to-severe homonymous quadrantanopia; it can be useful in settings where the current practice is confrontation visual field examination, and where standard conventional perimetry is not available.
AB - Unrecognized visual field loss is caused by a range of blinding eye conditions as well as serious brain diseases. The commonest cause of asymptomatic visual field loss is glaucoma. No screening tools have been proven cost-effective. Damato Multifixation Campimetry Online (DMCO), an inexpensive online test, has been evaluated as a future cost-beneficial tool to detect glaucoma. To further validate DMCO, this study aimed to test DMCO in a preselected population with neurological visual field loss. Methods: The study design was an evaluation of a diagnostic test. Patients were included if they had undergone surgery for epilepsy during 2011-2014, resulting in visual field loss. They were examined with DMCO and results were compared with those obtained with the Humphrey Field Analyzer (30:2 SITA-Fast). DMCO sensitivity and specificity were estimated with 95% confidence intervals. Results: The cohort comprised 40 patients (25 female and 15 male) with a mean age of 39 years (range 17-60 years). The mean visual acuity was >1.0 and all eyes had an intraocular pressure <21 mm Hg. Sensitivity and specificity of DMCO compared to the reference standard were 72.7 and 96.3%, respectively. Conclusions: DMCO detects moderate-to-severe homonymous quadrantanopia; it can be useful in settings where the current practice is confrontation visual field examination, and where standard conventional perimetry is not available.
KW - Advanced glycation end products
KW - Genetics
KW - Glaucoma
KW - Open angle
KW - Polymorphisms
U2 - 10.1159/000468942
DO - 10.1159/000468942
M3 - Journal article
C2 - 28535498
AN - SCOPUS:85020227810
VL - 58
SP - 85
EP - 93
JO - Ophthalmic Research
JF - Ophthalmic Research
SN - 0030-3747
IS - 2
ER -
ID: 182093302