Central venous oxygen saturation during hypovolaemic shock in humans
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Central venous oxygen saturation during hypovolaemic shock in humans. / Madsen, P; Iversen, H; Secher, N H; Iversen, Helle Klingenberg.
In: Scandinavian Journal of Clinical and Laboratory Investigation. Supplement, Vol. 53, No. 1, 02.1993, p. 67-72.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Central venous oxygen saturation during hypovolaemic shock in humans
AU - Madsen, P
AU - Iversen, H
AU - Secher, N H
AU - Iversen, Helle Klingenberg
PY - 1993/2
Y1 - 1993/2
N2 - We compared central venous oxygen saturation and central venous pressure (CVP) as indices of the effective blood volume during 50 degrees head-up tilt (anti-Trendelenburg's position) induced hypovolaemic shock in eight healthy subjects. Head-up tilt increased thoracic electrical impedance from 31 (28-36) (median and range) to 34 (30-40) Ohm, mean arterial pressure (MAP) from 79 (70-88) to 86 (80-99) mmHg, heart rate (HR) from 67 (56-71) to 99 (78-119) beats min-1 (p < 0.01) and total peripheral resistance (TPR) from 20 (16-32) to 36 (15-52) mmHg min l-1 (p < 0.03). Cardiac output decreased from 4.3 (3.0-4.8) to 2.7 (1.8-4.8) l min-1 (p < 0.03). After 29 (9-56) min presyncopal symptoms appeared, together with a decrease in MAP to 63 (43-79) mmHg, HR to 68 (30-112) beats min-1 and TPR to 22 (13-33) mmHg min l-1 (p < 0.02). During tilting CVP decreased from 3 (1-6) to 1 (-3-5) mmHg (p < 0.05) but thereafter remained stable. In contrast, central venous oxygen saturation showed a linear decrease with time from 0.75 (0.69-0.78) at rest to 0.60 (0.49-0.67) (p < 0.01) when presyncopal symptoms appeared. Central venous catheterization is a tool for measurement of central venous oxygen saturation in addition to recording of CVP. The results suggest that a reduced central blood volume is reflected more clearly in central venous oxygen saturation than in CVP.
AB - We compared central venous oxygen saturation and central venous pressure (CVP) as indices of the effective blood volume during 50 degrees head-up tilt (anti-Trendelenburg's position) induced hypovolaemic shock in eight healthy subjects. Head-up tilt increased thoracic electrical impedance from 31 (28-36) (median and range) to 34 (30-40) Ohm, mean arterial pressure (MAP) from 79 (70-88) to 86 (80-99) mmHg, heart rate (HR) from 67 (56-71) to 99 (78-119) beats min-1 (p < 0.01) and total peripheral resistance (TPR) from 20 (16-32) to 36 (15-52) mmHg min l-1 (p < 0.03). Cardiac output decreased from 4.3 (3.0-4.8) to 2.7 (1.8-4.8) l min-1 (p < 0.03). After 29 (9-56) min presyncopal symptoms appeared, together with a decrease in MAP to 63 (43-79) mmHg, HR to 68 (30-112) beats min-1 and TPR to 22 (13-33) mmHg min l-1 (p < 0.02). During tilting CVP decreased from 3 (1-6) to 1 (-3-5) mmHg (p < 0.05) but thereafter remained stable. In contrast, central venous oxygen saturation showed a linear decrease with time from 0.75 (0.69-0.78) at rest to 0.60 (0.49-0.67) (p < 0.01) when presyncopal symptoms appeared. Central venous catheterization is a tool for measurement of central venous oxygen saturation in addition to recording of CVP. The results suggest that a reduced central blood volume is reflected more clearly in central venous oxygen saturation than in CVP.
KW - Adult
KW - Blood Pressure
KW - Cardiac Output
KW - Cardiography, Impedance
KW - Central Venous Pressure
KW - Heart Rate
KW - Humans
KW - Oxygen
KW - Posture
KW - Shock
KW - Vascular Resistance
M3 - Journal article
C2 - 8451602
VL - 53
SP - 67
EP - 72
JO - Scandinavian Journal of Clinical and Laboratory Investigation. Supplement
JF - Scandinavian Journal of Clinical and Laboratory Investigation. Supplement
SN - 0085-591X
IS - 1
ER -
ID: 128985560