Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels

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Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. / Klein, Anders Bue; Trajkovska, Viktorija; Erritzoe, David; Haugbol, Steven; Madsen, Jacob; Baaré, William; Aznar, Susana; Knudsen, Gitte M.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 30, No. 11, 01.11.2010, p. e1-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Klein, AB, Trajkovska, V, Erritzoe, D, Haugbol, S, Madsen, J, Baaré, W, Aznar, S & Knudsen, GM 2010, 'Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels', Journal of Cerebral Blood Flow and Metabolism, vol. 30, no. 11, pp. e1-7. https://doi.org/10.1038/jcbfm.2010.114

APA

Klein, A. B., Trajkovska, V., Erritzoe, D., Haugbol, S., Madsen, J., Baaré, W., Aznar, S., & Knudsen, G. M. (2010). Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. Journal of Cerebral Blood Flow and Metabolism, 30(11), e1-7. https://doi.org/10.1038/jcbfm.2010.114

Vancouver

Klein AB, Trajkovska V, Erritzoe D, Haugbol S, Madsen J, Baaré W et al. Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. Journal of Cerebral Blood Flow and Metabolism. 2010 Nov 1;30(11):e1-7. https://doi.org/10.1038/jcbfm.2010.114

Author

Klein, Anders Bue ; Trajkovska, Viktorija ; Erritzoe, David ; Haugbol, Steven ; Madsen, Jacob ; Baaré, William ; Aznar, Susana ; Knudsen, Gitte M. / Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels. In: Journal of Cerebral Blood Flow and Metabolism. 2010 ; Vol. 30, No. 11. pp. e1-7.

Bibtex

@article{a0b1d742754d48d09d92aba6558b3c55,
title = "Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels",
abstract = "Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT(2A)) receptor or serotonin transporter (SERT) binding in healthy subjects. No statistically significant differences in 5-HT(2A) receptor or SERT binding were found between the val/val and met carriers, nor were blood BDNF values associated with SERT binding or 5-HT(2A) receptor binding. In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT(2A) or SERT binding.",
author = "Klein, {Anders Bue} and Viktorija Trajkovska and David Erritzoe and Steven Haugbol and Jacob Madsen and William Baar{\'e} and Susana Aznar and Knudsen, {Gitte M}",
year = "2010",
month = nov,
day = "1",
doi = "http://dx.doi.org/10.1038/jcbfm.2010.114",
language = "English",
volume = "30",
pages = "e1--7",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "11",

}

RIS

TY - JOUR

T1 - Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels

AU - Klein, Anders Bue

AU - Trajkovska, Viktorija

AU - Erritzoe, David

AU - Haugbol, Steven

AU - Madsen, Jacob

AU - Baaré, William

AU - Aznar, Susana

AU - Knudsen, Gitte M

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT(2A)) receptor or serotonin transporter (SERT) binding in healthy subjects. No statistically significant differences in 5-HT(2A) receptor or SERT binding were found between the val/val and met carriers, nor were blood BDNF values associated with SERT binding or 5-HT(2A) receptor binding. In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT(2A) or SERT binding.

AB - Recent studies have proposed an interrelation between the brain-derived neurotrophic factor (BDNF) val66met polymorphism and the serotonin system. In this study, we investigated whether the BDNF val66met polymorphism or blood BDNF levels are associated with cerebral 5-hydroxytryptamine 2A (5-HT(2A)) receptor or serotonin transporter (SERT) binding in healthy subjects. No statistically significant differences in 5-HT(2A) receptor or SERT binding were found between the val/val and met carriers, nor were blood BDNF values associated with SERT binding or 5-HT(2A) receptor binding. In conclusion, val66met BDNF polymorphism status is not associated with changes in the serotonergic system. Moreover, BDNF levels in blood do not correlate with either 5-HT(2A) or SERT binding.

U2 - http://dx.doi.org/10.1038/jcbfm.2010.114

DO - http://dx.doi.org/10.1038/jcbfm.2010.114

M3 - Journal article

VL - 30

SP - e1-7

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 11

ER -

ID: 34143150