Charting the excitability of premotor to motor connections while withholding or initiating a selected movement
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Charting the excitability of premotor to motor connections while withholding or initiating a selected movement. / Kroeger, Johan; Bäumer, Tobias; Jonas, Melanie; Rothwell, John C; Siebner, Hartwig R; Münchau, Alexander.
In: European Journal of Neuroscience, Vol. 32, No. 10, 01.11.2010, p. 1771-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Charting the excitability of premotor to motor connections while withholding or initiating a selected movement
AU - Kroeger, Johan
AU - Bäumer, Tobias
AU - Jonas, Melanie
AU - Rothwell, John C
AU - Siebner, Hartwig R
AU - Münchau, Alexander
N1 - © 2010 The Authors. European Journal of Neuroscience © 2010 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
PY - 2010/11/1
Y1 - 2010/11/1
N2 - In 19 healthy volunteers, we used transcranial magnetic stimulation (TMS) to probe the excitability in pathways linking the left dorsal premotor cortex and right primary motor cortex and those linking the left and right motor cortex during the response delay and the reaction time period while subjects performed a delayed response [symbol 1 (S1) - symbol 2 (S2)] Go-NoGo reaction time task with visual cues. Conditioning TMS pulses were applied to the left premotor or left motor cortex 8 ms before a test pulse was given to the right motor cortex at 300 or 1800 ms after S1 or 150 ms after S2. S1 coded for right-hand or left-hand movement, and S2 for release or stopping the prepared movement. Conditioning of the left premotor cortex led to interhemispheric inhibition at 300 ms post-S1, interhemispheric facilitation at 150 ms post-S2, and shorter reaction times in the move-left condition. Conditioning of the left motor cortex led to inhibition at 1800 ms post-S1 and 150 ms post-S2, and slower reaction times for move-right conditions, and inhibition at 300 and 1800 ms post-S1 for move-left conditions. Relative motor evoked potential amplitudes following premotor conditioning at 150 ms post-S2 were significantly smaller in 'NoGo' than in 'Go' trials for move-left instructions. We conclude that the excitability in left premotor/motor right motor pathways is context-dependent and affects motor behaviour. Thus, the left premotor cortex is engaged not only in action selection but also in withholding and releasing a preselected movement generated by the right motor cortex.
AB - In 19 healthy volunteers, we used transcranial magnetic stimulation (TMS) to probe the excitability in pathways linking the left dorsal premotor cortex and right primary motor cortex and those linking the left and right motor cortex during the response delay and the reaction time period while subjects performed a delayed response [symbol 1 (S1) - symbol 2 (S2)] Go-NoGo reaction time task with visual cues. Conditioning TMS pulses were applied to the left premotor or left motor cortex 8 ms before a test pulse was given to the right motor cortex at 300 or 1800 ms after S1 or 150 ms after S2. S1 coded for right-hand or left-hand movement, and S2 for release or stopping the prepared movement. Conditioning of the left premotor cortex led to interhemispheric inhibition at 300 ms post-S1, interhemispheric facilitation at 150 ms post-S2, and shorter reaction times in the move-left condition. Conditioning of the left motor cortex led to inhibition at 1800 ms post-S1 and 150 ms post-S2, and slower reaction times for move-right conditions, and inhibition at 300 and 1800 ms post-S1 for move-left conditions. Relative motor evoked potential amplitudes following premotor conditioning at 150 ms post-S2 were significantly smaller in 'NoGo' than in 'Go' trials for move-left instructions. We conclude that the excitability in left premotor/motor right motor pathways is context-dependent and affects motor behaviour. Thus, the left premotor cortex is engaged not only in action selection but also in withholding and releasing a preselected movement generated by the right motor cortex.
KW - Adult
KW - Brain Mapping
KW - Evoked Potentials, Motor
KW - Female
KW - Functional Laterality
KW - Hand
KW - Humans
KW - Male
KW - Motor Activity
KW - Motor Cortex
KW - Movement
KW - Neural Pathways
KW - Psychomotor Performance
KW - Transcranial Magnetic Stimulation
U2 - 10.1111/j.1460-9568.2010.07442.x
DO - 10.1111/j.1460-9568.2010.07442.x
M3 - Journal article
C2 - 21059111
VL - 32
SP - 1771
EP - 1779
JO - European Journal of Neuroscience
JF - European Journal of Neuroscience
SN - 0953-816X
IS - 10
ER -
ID: 33437682