Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure

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Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure. / Strauss, Gitte Irene; Edvinsson, Lars; Larsen, Fin Stolze; Møller, Kirsten; Knudsen, Karen Birgitte Moos.

In: Neuropeptides, Vol. 35, No. 3-4, 31.12.2001, p. 174-180.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Strauss, GI, Edvinsson, L, Larsen, FS, Møller, K & Knudsen, KBM 2001, 'Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure', Neuropeptides, vol. 35, no. 3-4, pp. 174-180.

APA

Strauss, G. I., Edvinsson, L., Larsen, F. S., Møller, K., & Knudsen, K. B. M. (2001). Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure. Neuropeptides, 35(3-4), 174-180.

Vancouver

Strauss GI, Edvinsson L, Larsen FS, Møller K, Knudsen KBM. Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure. Neuropeptides. 2001 Dec 31;35(3-4):174-180.

Author

Strauss, Gitte Irene ; Edvinsson, Lars ; Larsen, Fin Stolze ; Møller, Kirsten ; Knudsen, Karen Birgitte Moos. / Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure. In: Neuropeptides. 2001 ; Vol. 35, No. 3-4. pp. 174-180.

Bibtex

@article{8d8d2a69564b4a84a4d5d878078aba37,
title = "Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure",
abstract = "The present study investigated the circulating levels and cerebral fluxes of calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP), and neuropeptide Y (NPY) and their relation to cerebral blood flow (CBF) during normoventilation and hyperventilation in patients with fulminant hepatic failure (FHF). Sixteen patients with FHF were studied and compared to six patients with cirrhosis of the liver. CBF was measured by the (133)Xe wash-out technique. Blood samples were obtained simultaneously from the artery and internal jugular bulb. Concentrations of CGRP and VIP were higher in FHF than in cirrhosis, 87 (55-218) vs. 29 (21-42) pmol/L, and 11 (6-29) vs. 5 (3-9)pmol/L, respectively. NPY was normal, none of the measures were related to CBF, and there was no detectable net brain fluxes. Hyperventilation did not alter any of the measures. CGRP and VIP in FHF seem to reflect hemodynamic changes in the systemic rather than in the cerebral circulation.",
author = "Strauss, {Gitte Irene} and Lars Edvinsson and Larsen, {Fin Stolze} and Kirsten M{\o}ller and Knudsen, {Karen Birgitte Moos}",
year = "2001",
month = dec,
day = "31",
language = "English",
volume = "35",
pages = "174--180",
journal = "Neuropeptides",
issn = "0143-4179",
publisher = "Churchill Livingstone",
number = "3-4",

}

RIS

TY - JOUR

T1 - Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure

AU - Strauss, Gitte Irene

AU - Edvinsson, Lars

AU - Larsen, Fin Stolze

AU - Møller, Kirsten

AU - Knudsen, Karen Birgitte Moos

PY - 2001/12/31

Y1 - 2001/12/31

N2 - The present study investigated the circulating levels and cerebral fluxes of calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP), and neuropeptide Y (NPY) and their relation to cerebral blood flow (CBF) during normoventilation and hyperventilation in patients with fulminant hepatic failure (FHF). Sixteen patients with FHF were studied and compared to six patients with cirrhosis of the liver. CBF was measured by the (133)Xe wash-out technique. Blood samples were obtained simultaneously from the artery and internal jugular bulb. Concentrations of CGRP and VIP were higher in FHF than in cirrhosis, 87 (55-218) vs. 29 (21-42) pmol/L, and 11 (6-29) vs. 5 (3-9)pmol/L, respectively. NPY was normal, none of the measures were related to CBF, and there was no detectable net brain fluxes. Hyperventilation did not alter any of the measures. CGRP and VIP in FHF seem to reflect hemodynamic changes in the systemic rather than in the cerebral circulation.

AB - The present study investigated the circulating levels and cerebral fluxes of calcitonin gene-related peptide (CGRP), vasoactive intestinal peptide (VIP), and neuropeptide Y (NPY) and their relation to cerebral blood flow (CBF) during normoventilation and hyperventilation in patients with fulminant hepatic failure (FHF). Sixteen patients with FHF were studied and compared to six patients with cirrhosis of the liver. CBF was measured by the (133)Xe wash-out technique. Blood samples were obtained simultaneously from the artery and internal jugular bulb. Concentrations of CGRP and VIP were higher in FHF than in cirrhosis, 87 (55-218) vs. 29 (21-42) pmol/L, and 11 (6-29) vs. 5 (3-9)pmol/L, respectively. NPY was normal, none of the measures were related to CBF, and there was no detectable net brain fluxes. Hyperventilation did not alter any of the measures. CGRP and VIP in FHF seem to reflect hemodynamic changes in the systemic rather than in the cerebral circulation.

M3 - Journal article

VL - 35

SP - 174

EP - 180

JO - Neuropeptides

JF - Neuropeptides

SN - 0143-4179

IS - 3-4

ER -

ID: 162987675