Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients

Research output: Contribution to journal › Journal article › Research › peer-review

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Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients. / Erritzoe, David; Rasmussen, Hans; Kristiansen, Klaus Nyegaard; Frokjaer, Vibe G; Haugbol, Steven; Pinborg, Lars; Baaré, William; Svarer, Claus; Madsen, Jacob; Lublin, Henrik Kai Francis; Knudsen, Gitte Moos; Glenthøj, Birte Yding.

In: European Neuropsychopharmacology, Vol. 33, No. 10, 01.09.2008, p. 2435-41.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Erritzoe, D, Rasmussen, H, Kristiansen, KN, Frokjaer, VG, Haugbol, S, Pinborg, L, Baaré, W, Svarer, C, Madsen, J, Lublin, HKF, Knudsen, GM & Glenthøj, BY 2008, 'Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients', European Neuropsychopharmacology, vol. 33, no. 10, pp. 2435-41. https://doi.org/10.1038/sj.npp.1301656, https://doi.org/10.1038/sj.npp.1301656

APA

Erritzoe, D., Rasmussen, H., Kristiansen, K. N., Frokjaer, V. G., Haugbol, S., Pinborg, L., Baaré, W., Svarer, C., Madsen, J., Lublin, H. K. F., Knudsen, G. M., & Glenthøj, B. Y. (2008). Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients. European Neuropsychopharmacology, 33(10), 2435-41. https://doi.org/10.1038/sj.npp.1301656, https://doi.org/10.1038/sj.npp.1301656

Vancouver

Erritzoe D, Rasmussen H, Kristiansen KN, Frokjaer VG, Haugbol S, Pinborg L et al. Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients. European Neuropsychopharmacology. 2008 Sep 1;33(10):2435-41. https://doi.org/10.1038/sj.npp.1301656, https://doi.org/10.1038/sj.npp.1301656

Author

Erritzoe, David ; Rasmussen, Hans ; Kristiansen, Klaus Nyegaard ; Frokjaer, Vibe G ; Haugbol, Steven ; Pinborg, Lars ; Baaré, William ; Svarer, Claus ; Madsen, Jacob ; Lublin, Henrik Kai Francis ; Knudsen, Gitte Moos ; Glenthøj, Birte Yding. / Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients. In: European Neuropsychopharmacology. 2008 ; Vol. 33, No. 10. pp. 2435-41.

Bibtex

@article{f5e44f10f37011ddbf70000ea68e967b,
title = "Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients",
abstract = "The serotonin 5-HT(2A) receptor is suspected to be involved in a number of psychiatric disorders, including schizophrenia. In particular, atypical antipsychotics have antagonistic effects on the 5-HT(2A) receptors, supporting a specific role of the 5-HT(2A) receptor in the pathophysiology of this disease. The aim of this study is to investigate cortical and subcortical 5-HT(2A) binding in neuroleptic-naive schizophrenic patients. Fifteen neuroleptic-naive patients diagnosed with schizophrenia (age 27.5+/-4.5 years), 11 men and 4 women, and 15 healthy control subjects matched for age (28.5+/-5.7 years) and gender underwent a 40 min positron emission tomography (PET) study using the 5-HT(2A) antagonist, [(18)F]altanserin, as a radioligand. PET images were co-registered to 3 T magnetic resonance images (MRIs) for each individual subject, and ROIs were applied automatically onto the individual MRIs and PET images. The cerebellum was used as a reference region. The binding potential of specific tracer binding (BP(p)) was used as the outcome measure. No significant difference was seen in cortical receptor distribution between patients and controls. An increase in 5-HT(2A) receptor binding in the caudate nucleus was detected in the group of schizophrenic patients (0.7+/-0.1) when compared to the healthy controls (0.5+/-0.3) (p=0.02). Our results confirm other in vivo findings of no difference in cortical 5-HT(2A) receptor binding between first-episode antipsychotic-naive schizophrenic patients and age- and gender-matched healthy control subjects. However, a preliminary finding of increased 5-HT(2A) binding in the caudate nucleus requires further investigation to explore the relation of subcortical and cortical 5-HT(2A) receptor binding.",
author = "David Erritzoe and Hans Rasmussen and Kristiansen, {Klaus Nyegaard} and Frokjaer, {Vibe G} and Steven Haugbol and Lars Pinborg and William Baar{\'e} and Claus Svarer and Jacob Madsen and Lublin, {Henrik Kai Francis} and Knudsen, {Gitte Moos} and Glenth{\o}j, {Birte Yding}",
year = "2008",
month = sep,
day = "1",
doi = "10.1038/sj.npp.1301656",
language = "English",
volume = "33",
pages = "2435--41",
journal = "European Neuropsychopharmacology",
issn = "0924-977X",
publisher = "Elsevier",
number = "10",

}

RIS

TY - JOUR

T1 - Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients

AU - Erritzoe, David

AU - Rasmussen, Hans

AU - Kristiansen, Klaus Nyegaard

AU - Frokjaer, Vibe G

AU - Haugbol, Steven

AU - Pinborg, Lars

AU - Baaré, William

AU - Svarer, Claus

AU - Madsen, Jacob

AU - Lublin, Henrik Kai Francis

AU - Knudsen, Gitte Moos

AU - Glenthøj, Birte Yding

PY - 2008/9/1

Y1 - 2008/9/1

N2 - The serotonin 5-HT(2A) receptor is suspected to be involved in a number of psychiatric disorders, including schizophrenia. In particular, atypical antipsychotics have antagonistic effects on the 5-HT(2A) receptors, supporting a specific role of the 5-HT(2A) receptor in the pathophysiology of this disease. The aim of this study is to investigate cortical and subcortical 5-HT(2A) binding in neuroleptic-naive schizophrenic patients. Fifteen neuroleptic-naive patients diagnosed with schizophrenia (age 27.5+/-4.5 years), 11 men and 4 women, and 15 healthy control subjects matched for age (28.5+/-5.7 years) and gender underwent a 40 min positron emission tomography (PET) study using the 5-HT(2A) antagonist, [(18)F]altanserin, as a radioligand. PET images were co-registered to 3 T magnetic resonance images (MRIs) for each individual subject, and ROIs were applied automatically onto the individual MRIs and PET images. The cerebellum was used as a reference region. The binding potential of specific tracer binding (BP(p)) was used as the outcome measure. No significant difference was seen in cortical receptor distribution between patients and controls. An increase in 5-HT(2A) receptor binding in the caudate nucleus was detected in the group of schizophrenic patients (0.7+/-0.1) when compared to the healthy controls (0.5+/-0.3) (p=0.02). Our results confirm other in vivo findings of no difference in cortical 5-HT(2A) receptor binding between first-episode antipsychotic-naive schizophrenic patients and age- and gender-matched healthy control subjects. However, a preliminary finding of increased 5-HT(2A) binding in the caudate nucleus requires further investigation to explore the relation of subcortical and cortical 5-HT(2A) receptor binding.

AB - The serotonin 5-HT(2A) receptor is suspected to be involved in a number of psychiatric disorders, including schizophrenia. In particular, atypical antipsychotics have antagonistic effects on the 5-HT(2A) receptors, supporting a specific role of the 5-HT(2A) receptor in the pathophysiology of this disease. The aim of this study is to investigate cortical and subcortical 5-HT(2A) binding in neuroleptic-naive schizophrenic patients. Fifteen neuroleptic-naive patients diagnosed with schizophrenia (age 27.5+/-4.5 years), 11 men and 4 women, and 15 healthy control subjects matched for age (28.5+/-5.7 years) and gender underwent a 40 min positron emission tomography (PET) study using the 5-HT(2A) antagonist, [(18)F]altanserin, as a radioligand. PET images were co-registered to 3 T magnetic resonance images (MRIs) for each individual subject, and ROIs were applied automatically onto the individual MRIs and PET images. The cerebellum was used as a reference region. The binding potential of specific tracer binding (BP(p)) was used as the outcome measure. No significant difference was seen in cortical receptor distribution between patients and controls. An increase in 5-HT(2A) receptor binding in the caudate nucleus was detected in the group of schizophrenic patients (0.7+/-0.1) when compared to the healthy controls (0.5+/-0.3) (p=0.02). Our results confirm other in vivo findings of no difference in cortical 5-HT(2A) receptor binding between first-episode antipsychotic-naive schizophrenic patients and age- and gender-matched healthy control subjects. However, a preliminary finding of increased 5-HT(2A) binding in the caudate nucleus requires further investigation to explore the relation of subcortical and cortical 5-HT(2A) receptor binding.

U2 - 10.1038/sj.npp.1301656

DO - 10.1038/sj.npp.1301656

M3 - Journal article

C2 - 18288096

VL - 33

SP - 2435

EP - 2441

JO - European Neuropsychopharmacology

JF - European Neuropsychopharmacology

SN - 0924-977X

IS - 10

ER -

ID: 10152797