Cortical Thickness Changes Associated with Photoparoxysmal Response
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Cortical Thickness Changes Associated with Photoparoxysmal Response. / Hanganu, Alexandru; Groppa, Stanislav A; Deuschl, Günther; Siebner, Hartwig; Moeller, Friederike; Siniatchkin, Michael; Stephani, Ulrich; Groppa, Sergiu.
In: Brain Topography, 01.02.2014, p. 1-8.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Cortical Thickness Changes Associated with Photoparoxysmal Response
AU - Hanganu, Alexandru
AU - Groppa, Stanislav A
AU - Deuschl, Günther
AU - Siebner, Hartwig
AU - Moeller, Friederike
AU - Siniatchkin, Michael
AU - Stephani, Ulrich
AU - Groppa, Sergiu
PY - 2014/2/1
Y1 - 2014/2/1
N2 - Photoparoxysmal response (PPR) is an EEG trait of spike and spike-wave discharges in response to photic stimulation that is closely linked to idiopathic generalized epilepsy (IGE). In our previous studies we showed that PPR is associated with functional alterations in the occipital and frontal cortices. The aim of the present study was to determine structural changes associated with PPR. For this purpose we analysed the cortical thickness as derived from T1 MRI images in PPR-positive-subjects (n = 12; 15.5 ± 8.6 years; 4 males), PPR-positive-IGE-patients (n = 12; 14.9 ± 2.7 years; 4 males) and compared these groups with a group of PPR-negative-healthy-controls (HC, n = 17; 15.3 ± 3.6 years; 6 males). Our results revealed an increase of cortical thickness in the occipital, frontal and parietal cortices bilaterally in PPR-positive-subjects in comparison to HC. Moreover PPR-positive-subjects presented a significant decrease of cortical thickness in the temporal cortex in the same group contrast. IGE patients exhibited lower cortical thickness in the temporal lobe bilaterally and in the right paracentral region in comparison to PPR-positive-subjects. Our study demonstrates structural changes in the occipital lobe, frontoparietal regions and temporal lobe, which also show functional changes associated with PPR. Patients with epilepsy present changes in the temporal lobe and supplementary motor area.
AB - Photoparoxysmal response (PPR) is an EEG trait of spike and spike-wave discharges in response to photic stimulation that is closely linked to idiopathic generalized epilepsy (IGE). In our previous studies we showed that PPR is associated with functional alterations in the occipital and frontal cortices. The aim of the present study was to determine structural changes associated with PPR. For this purpose we analysed the cortical thickness as derived from T1 MRI images in PPR-positive-subjects (n = 12; 15.5 ± 8.6 years; 4 males), PPR-positive-IGE-patients (n = 12; 14.9 ± 2.7 years; 4 males) and compared these groups with a group of PPR-negative-healthy-controls (HC, n = 17; 15.3 ± 3.6 years; 6 males). Our results revealed an increase of cortical thickness in the occipital, frontal and parietal cortices bilaterally in PPR-positive-subjects in comparison to HC. Moreover PPR-positive-subjects presented a significant decrease of cortical thickness in the temporal cortex in the same group contrast. IGE patients exhibited lower cortical thickness in the temporal lobe bilaterally and in the right paracentral region in comparison to PPR-positive-subjects. Our study demonstrates structural changes in the occipital lobe, frontoparietal regions and temporal lobe, which also show functional changes associated with PPR. Patients with epilepsy present changes in the temporal lobe and supplementary motor area.
U2 - 10.1007/s10548-014-0353-y
DO - 10.1007/s10548-014-0353-y
M3 - Journal article
C2 - 24487625
SP - 1
EP - 8
JO - Brain Topography
JF - Brain Topography
SN - 0896-0267
ER -
ID: 138132370