Decreased blood-brain barrier permeability to sodium in early experimental diabetes
Research output: Contribution to journal › Journal article › Research › peer-review
Blood-brain barrier (BBB) permeability to 24Na+, 36Cl-, and [3H]sucrose was studied in rats after 2 wk of streptozocin-induced diabetes. The PS (permeability-surface area product) for Na+ in the cortex of the frontal lobes was 5.4 +/- 0.6 (10(-5) cm3 X g-1 X s-1; +/- SD) in diabetic rats compared with 7.1 +/- 1.7 in control rats. In the occipital cortex, the values were 7.6 +/- 1.5 and 9.9 +/- 1.6, respectively. In contrast, BBB permeability to Cl- and sucrose remained unchanged. We conclude that a selective alteration in BBB permeability to Na+ unrelated to changes in brain capillary surface area is present in experimental diabetes.
Original language | English |
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Journal | Diabetes |
Volume | 35 |
Issue number | 12 |
Pages (from-to) | 1371-3 |
Number of pages | 3 |
ISSN | 0012-1797 |
DOIs | |
Publication status | Published - Dec 1986 |
- Animals, Blood-Brain Barrier, Chlorides/metabolism, Diabetes Mellitus, Experimental/metabolism, Glucose/metabolism, Male, Rats, Rats, Inbred Strains, Sodium/metabolism, Sucrose/metabolism
Research areas
ID: 275605177