Early stopping in clinical PET studies: How to reduce expense and exposure

Research output: Contribution to journal › Review › Research › peer-review

Standard

Early stopping in clinical PET studies : How to reduce expense and exposure. / Svensson, Jonas E.; Schain, Martin; Knudsen, Gitte M.; Ogden, R. Todd; Plavén-Sigray, Pontus.

In: Journal of Cerebral Blood Flow and Metabolism, Vol. 41, No. 11, 2021, p. 2805-2819.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Svensson, JE, Schain, M, Knudsen, GM, Ogden, RT & Plavén-Sigray, P 2021, 'Early stopping in clinical PET studies: How to reduce expense and exposure', Journal of Cerebral Blood Flow and Metabolism, vol. 41, no. 11, pp. 2805-2819. https://doi.org/10.1177/0271678X211017796

APA

Svensson, J. E., Schain, M., Knudsen, G. M., Ogden, R. T., & Plavén-Sigray, P. (2021). Early stopping in clinical PET studies: How to reduce expense and exposure. Journal of Cerebral Blood Flow and Metabolism, 41(11), 2805-2819. https://doi.org/10.1177/0271678X211017796

Vancouver

Svensson JE, Schain M, Knudsen GM, Ogden RT, Plavén-Sigray P. Early stopping in clinical PET studies: How to reduce expense and exposure. Journal of Cerebral Blood Flow and Metabolism. 2021;41(11):2805-2819. https://doi.org/10.1177/0271678X211017796

Author

Svensson, Jonas E. ; Schain, Martin ; Knudsen, Gitte M. ; Ogden, R. Todd ; Plavén-Sigray, Pontus. / Early stopping in clinical PET studies : How to reduce expense and exposure. In: Journal of Cerebral Blood Flow and Metabolism. 2021 ; Vol. 41, No. 11. pp. 2805-2819.

Bibtex

@article{ff2a145c098c4cf687c3ee219f220b40,
title = "Early stopping in clinical PET studies: How to reduce expense and exposure",
abstract = "Clinical positron emission tomography (PET) research is costly and entails exposing participants to radioactivity. Researchers should therefore aim to include just the number of subjects needed to fulfill the purpose of the study. In this tutorial we show how to apply sequential Bayes Factor testing in order to stop the recruitment of subjects in a clinical PET study as soon as enough data have been collected to make a conclusion. By using simulations, we demonstrate that it is possible to stop a study early, while keeping the number of erroneous conclusions low. We then apply sequential Bayes Factor testing to a real PET data set and show that it is possible to obtain support in favor of an effect while simultaneously reducing the sample size with 30%. Using this procedure allows researchers to reduce expense and radioactivity exposure for a range of effect sizes relevant for PET research.",
keywords = "Bayes factor, Early stopping, positron emission tomography, sequential testing, tutorial",
author = "Svensson, {Jonas E.} and Martin Schain and Knudsen, {Gitte M.} and Ogden, {R. Todd} and Pontus Plav{\'e}n-Sigray",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2021.",
year = "2021",
doi = "10.1177/0271678X211017796",
language = "English",
volume = "41",
pages = "2805--2819",
journal = "Journal of Cerebral Blood Flow and Metabolism",
issn = "0271-678X",
publisher = "SAGE Publications",
number = "11",

}

RIS

TY - JOUR

T1 - Early stopping in clinical PET studies

T2 - How to reduce expense and exposure

AU - Svensson, Jonas E.

AU - Schain, Martin

AU - Knudsen, Gitte M.

AU - Ogden, R. Todd

AU - Plavén-Sigray, Pontus

N1 - Publisher Copyright: © The Author(s) 2021.

PY - 2021

Y1 - 2021

N2 - Clinical positron emission tomography (PET) research is costly and entails exposing participants to radioactivity. Researchers should therefore aim to include just the number of subjects needed to fulfill the purpose of the study. In this tutorial we show how to apply sequential Bayes Factor testing in order to stop the recruitment of subjects in a clinical PET study as soon as enough data have been collected to make a conclusion. By using simulations, we demonstrate that it is possible to stop a study early, while keeping the number of erroneous conclusions low. We then apply sequential Bayes Factor testing to a real PET data set and show that it is possible to obtain support in favor of an effect while simultaneously reducing the sample size with 30%. Using this procedure allows researchers to reduce expense and radioactivity exposure for a range of effect sizes relevant for PET research.

AB - Clinical positron emission tomography (PET) research is costly and entails exposing participants to radioactivity. Researchers should therefore aim to include just the number of subjects needed to fulfill the purpose of the study. In this tutorial we show how to apply sequential Bayes Factor testing in order to stop the recruitment of subjects in a clinical PET study as soon as enough data have been collected to make a conclusion. By using simulations, we demonstrate that it is possible to stop a study early, while keeping the number of erroneous conclusions low. We then apply sequential Bayes Factor testing to a real PET data set and show that it is possible to obtain support in favor of an effect while simultaneously reducing the sample size with 30%. Using this procedure allows researchers to reduce expense and radioactivity exposure for a range of effect sizes relevant for PET research.

KW - Bayes factor

KW - Early stopping

KW - positron emission tomography

KW - sequential testing

KW - tutorial

U2 - 10.1177/0271678X211017796

DO - 10.1177/0271678X211017796

M3 - Review

C2 - 34018825

AN - SCOPUS:85106419996

VL - 41

SP - 2805

EP - 2819

JO - Journal of Cerebral Blood Flow and Metabolism

JF - Journal of Cerebral Blood Flow and Metabolism

SN - 0271-678X

IS - 11

ER -

ID: 272236593