Glial and neuronal control of brain blood flow
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Glial and neuronal control of brain blood flow. / Attwell, David; Buchan, Alastair M; Charpak, Serge; Lauritzen, Martin; Macvicar, Brian A; Newman, Eric A.
In: Nature, Vol. 468, No. 7321, 2010, p. 232-243.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Glial and neuronal control of brain blood flow
AU - Attwell, David
AU - Buchan, Alastair M
AU - Charpak, Serge
AU - Lauritzen, Martin
AU - Macvicar, Brian A
AU - Newman, Eric A
PY - 2010
Y1 - 2010
N2 - Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.
AB - Blood flow in the brain is regulated by neurons and astrocytes. Knowledge of how these cells control blood flow is crucial for understanding how neural computation is powered, for interpreting functional imaging scans of brains, and for developing treatments for neurological disorders. It is now recognized that neurotransmitter-mediated signalling has a key role in regulating cerebral blood flow, that much of this control is mediated by astrocytes, that oxygen modulates blood flow regulation, and that blood flow may be controlled by capillaries as well as by arterioles. These conceptual shifts in our understanding of cerebral blood flow control have important implications for the development of new therapeutic approaches.
U2 - 10.1038/nature09613
DO - 10.1038/nature09613
M3 - Journal article
VL - 468
SP - 232
EP - 243
JO - Nature
JF - Nature
SN - 0028-0836
IS - 7321
ER -
ID: 34181870