Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy
Research output: Contribution to journal › Journal article › Research › peer-review
Objective: We investigated if Growth and Differentiation Factor 15 (GDF-15) can be used as a biomarker to distinguish patients with mitochondrial myopathy from patients with other myopathies. Methods: Serum GDF-15 was measured in 28 patients with mitochondrial disease, 24 with metabolic myopathies, 27 with muscular dystrophy and 21 healthy controls. Results and conclusions: Our findings indicate that elevated GDF-15 can distinguish patients with mitochondrial myopathy from other myopathies, including metabolic myopathies. This suggests that increases in GDF-15 is specific to respiratory chain dysfunction rather than general metabolic dysfunction or muscle defect.
Original language | English |
---|---|
Journal | Mitochondrion |
Volume | 50 |
Pages (from-to) | 35-41 |
ISSN | 1567-7249 |
DOIs | |
Publication status | Published - Jan 2020 |
- Exercise, Growth and differentiation factor 15, Metabolic myopathy, Mitochondrial myopathy, Muscular dystrophy
Research areas
ID: 240243210