High trait aggression in men is associated with low 5-HT levels, as indexed by 5-HT4 receptor binding
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High trait aggression in men is associated with low 5-HT levels, as indexed by 5-HT4 receptor binding. / da Cunha-Bang, Sofi; Mc Mahon, Brenda; Fisher, Patrick MacDonald; Jensen, Peter Steen; Svarer, Claus; Knudsen, Gitte Moos.
In: Social Cognitive and Affective Neuroscience (Online), Vol. 11, No. 4, 04.2016, p. 548-55.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - High trait aggression in men is associated with low 5-HT levels, as indexed by 5-HT4 receptor binding
AU - da Cunha-Bang, Sofi
AU - Mc Mahon, Brenda
AU - Fisher, Patrick MacDonald
AU - Jensen, Peter Steen
AU - Svarer, Claus
AU - Knudsen, Gitte Moos
N1 - © The Author (2016). Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.
PY - 2016/4
Y1 - 2016/4
N2 - Impulsive aggression has commonly been associated with a dysfunction of the serotonin (5-HT) system: many, but not all, studies point to an inverse relationship between 5-HT and aggression. As cerebral 5-HT4 receptor (5-HT4R) binding has recently been recognized as a proxy for stable brain levels of 5-HT, we here test the hypothesis in healthy men and women that brain 5-HT levels, as indexed by cerebral 5-HT4R, are inversely correlated with trait aggression and impulsivity. Sixty-one individuals (47 men) underwent positron emission tomography scanning with the radioligand [(11)C]SB207145 for quantification of brain 5-HT4R binding. The Buss-Perry Aggression Questionnaire (BPAQ) and the Barratt Impulsiveness Scale were used for assessment of trait aggression and trait impulsivity. Among male subjects, there was a positive correlation between global 5-HT4R and BPAQ total score (P = 0.037) as well as BPAQ physical aggression (P = 0.025). No main effect of global 5-HT4R on trait aggression or impulsivity was found in the mixed gender sample, but there was evidence for sex interaction effects in the relationship between global 5-HT4R and BPAQ physical aggression. In conclusion we found that low cerebral 5-HT levels, as indexed by 5-HT4R binding were associated with high trait aggression in males, but not in females.
AB - Impulsive aggression has commonly been associated with a dysfunction of the serotonin (5-HT) system: many, but not all, studies point to an inverse relationship between 5-HT and aggression. As cerebral 5-HT4 receptor (5-HT4R) binding has recently been recognized as a proxy for stable brain levels of 5-HT, we here test the hypothesis in healthy men and women that brain 5-HT levels, as indexed by cerebral 5-HT4R, are inversely correlated with trait aggression and impulsivity. Sixty-one individuals (47 men) underwent positron emission tomography scanning with the radioligand [(11)C]SB207145 for quantification of brain 5-HT4R binding. The Buss-Perry Aggression Questionnaire (BPAQ) and the Barratt Impulsiveness Scale were used for assessment of trait aggression and trait impulsivity. Among male subjects, there was a positive correlation between global 5-HT4R and BPAQ total score (P = 0.037) as well as BPAQ physical aggression (P = 0.025). No main effect of global 5-HT4R on trait aggression or impulsivity was found in the mixed gender sample, but there was evidence for sex interaction effects in the relationship between global 5-HT4R and BPAQ physical aggression. In conclusion we found that low cerebral 5-HT levels, as indexed by 5-HT4R binding were associated with high trait aggression in males, but not in females.
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1093/scan/nsv140
DO - 10.1093/scan/nsv140
M3 - Journal article
C2 - 26772668
VL - 11
SP - 548
EP - 555
JO - Social Cognitive and Affective Neuroscience
JF - Social Cognitive and Affective Neuroscience
SN - 1749-5024
IS - 4
ER -
ID: 164620568