Imitation in patients with Gilles de la Tourette syndrome--a behavioral study
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Imitation in patients with Gilles de la Tourette syndrome--a behavioral study. / Jonas, Melanie; Thomalla, Götz; Biermann-Ruben, Katja; Siebner, Hartwig Roman; Müller-Vahl, Kirsten; Bäumer, Tobias; Gerloff, Christian; Schnitzler, Alfons; Orth, Michael; Münchau, Alexander.
In: Movement Disorders, Vol. 25, No. 8, 15.06.2010, p. 991-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Imitation in patients with Gilles de la Tourette syndrome--a behavioral study
AU - Jonas, Melanie
AU - Thomalla, Götz
AU - Biermann-Ruben, Katja
AU - Siebner, Hartwig Roman
AU - Müller-Vahl, Kirsten
AU - Bäumer, Tobias
AU - Gerloff, Christian
AU - Schnitzler, Alfons
AU - Orth, Michael
AU - Münchau, Alexander
N1 - (c) 2010 Movement Disorder Society.
PY - 2010/6/15
Y1 - 2010/6/15
N2 - Echophenomena in Gilles de la Tourette syndrome (GTS) may relate to deficient processing of observed biological movements. This would be reflected in altered effects of movement observation on motor responses in these patients. We studied reaction times in 11 unmedicated GTS patients without psychiatric comorbidity and healthy subjects. In experiment 1, participants imitated single biological finger movement stimuli or nonbiological dot movement stimuli immediately. In experiment 2, participants responded to a tone while viewing biological or nonbiological movement stimuli that were either compatible (identical) or incompatible (different) with their response. In experiment 1, both patients and healthy subjects responded faster to single biological than to nonbiological stimuli. In experiment 2, biological stimuli caused a larger compatibility-effect in responses than nonbiological stimuli in both groups, provided stimulus presentation and response initiation coincided. Healthy subjects responded faster to compatible biological than nonbiological stimuli. In contrast, GTS patients responded slower to incompatible biological than nonbiological stimuli. Patients' mean reaction time in experiment 2 correlated with phonic tic-frequency. Motor facilitation by observing biological movements appears to rely on concomitance of stimuli and responses in GTS patients and healthy individuals. Differing behavioral effects of movement observation in GTS might reflect altered activation of an action observation-execution matching system. To avoid unwanted movements GTS patients probably have to inhibit motor activation induced by observed movement automatically. Thus, movement stimuli may facilitate similar motor responses less but interfere more with different responses in these patients.
AB - Echophenomena in Gilles de la Tourette syndrome (GTS) may relate to deficient processing of observed biological movements. This would be reflected in altered effects of movement observation on motor responses in these patients. We studied reaction times in 11 unmedicated GTS patients without psychiatric comorbidity and healthy subjects. In experiment 1, participants imitated single biological finger movement stimuli or nonbiological dot movement stimuli immediately. In experiment 2, participants responded to a tone while viewing biological or nonbiological movement stimuli that were either compatible (identical) or incompatible (different) with their response. In experiment 1, both patients and healthy subjects responded faster to single biological than to nonbiological stimuli. In experiment 2, biological stimuli caused a larger compatibility-effect in responses than nonbiological stimuli in both groups, provided stimulus presentation and response initiation coincided. Healthy subjects responded faster to compatible biological than nonbiological stimuli. In contrast, GTS patients responded slower to incompatible biological than nonbiological stimuli. Patients' mean reaction time in experiment 2 correlated with phonic tic-frequency. Motor facilitation by observing biological movements appears to rely on concomitance of stimuli and responses in GTS patients and healthy individuals. Differing behavioral effects of movement observation in GTS might reflect altered activation of an action observation-execution matching system. To avoid unwanted movements GTS patients probably have to inhibit motor activation induced by observed movement automatically. Thus, movement stimuli may facilitate similar motor responses less but interfere more with different responses in these patients.
KW - Adult
KW - Analysis of Variance
KW - Female
KW - Humans
KW - Imitative Behavior
KW - Male
KW - Middle Aged
KW - Movement
KW - Psychomotor Performance
KW - Reaction Time
KW - Severity of Illness Index
KW - Statistics as Topic
KW - Tourette Syndrome
KW - Young Adult
U2 - 10.1002/mds.22994
DO - 10.1002/mds.22994
M3 - Journal article
C2 - 20535824
VL - 25
SP - 991
EP - 999
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 8
ER -
ID: 33438322