Involvement of calcitonin gene-related peptide in migraine: regional cerebral blood flow and blood flow velocity in migraine patients
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Involvement of calcitonin gene-related peptide in migraine : regional cerebral blood flow and blood flow velocity in migraine patients. / Lassen, L H; Jacobsen, V B; Haderslev, P A; Sperling, B; Iversen, Helle Klingenberg; Olesen, J; Tfelt-Hansen, P.
In: Journal of Headache and Pain, Vol. 9, No. 3, 06.2008, p. 151-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Involvement of calcitonin gene-related peptide in migraine
T2 - regional cerebral blood flow and blood flow velocity in migraine patients
AU - Lassen, L H
AU - Jacobsen, V B
AU - Haderslev, P A
AU - Sperling, B
AU - Iversen, Helle Klingenberg
AU - Olesen, J
AU - Tfelt-Hansen, P
PY - 2008/6
Y1 - 2008/6
N2 - Calcitonin gene-related peptide (CGRP)-containing nerves are closely associated with cranial blood vessels. CGRP is the most potent vasodilator known in isolated cerebral blood vessels. CGRP can induce migraine attacks, and two selective CGRP receptor antagonists are effective in the treatment of migraine attacks. It is therefore important to investigate its mechanism of action in patients with migraine. We here investigate the effects of intravenous human alpha-CGRP (halphaCGRP) on intracranial hemodynamics. In a double-blind, cross-over study, the effect of intravenous infusion of halphaCGRP (2 mug/min) or placebo for 20 min was studied in 12 patients with migraine without aura outside attacks. Xenon-133 inhalation SPECT-determined regional cerebral blood flow (rCBF) and transcranial Doppler (TCD)-determined blood velocity (V (mean)) in the middle cerebral artery (MCA), as well as the heart rate and blood pressure, were the outcome parameters. No change of rCBF was observed at the end of infusion [1.2% +/- 1.7 with halphaCGRP, vs. -1.6% +/- 3.1 with placebo (mean +/- SD)] (P = 0.43). V (mean) in MCA decreased to 13.5% +/- 3.6 with halphaCGRP versus 0.6% +/- 1.8 with placebo (P < 0.005). Since rCBF was unchanged, this indicates a dilation of the MCA. halphaCGRP induced a decrease in MAP (12%) (P < 0.005) and an increase in heart rate (58%) (P < 0.0001). CGRP dilates cerebral arteries, but the effect is so small that it is unlikely to be the only mechanism of CGRP-induced migraine.
AB - Calcitonin gene-related peptide (CGRP)-containing nerves are closely associated with cranial blood vessels. CGRP is the most potent vasodilator known in isolated cerebral blood vessels. CGRP can induce migraine attacks, and two selective CGRP receptor antagonists are effective in the treatment of migraine attacks. It is therefore important to investigate its mechanism of action in patients with migraine. We here investigate the effects of intravenous human alpha-CGRP (halphaCGRP) on intracranial hemodynamics. In a double-blind, cross-over study, the effect of intravenous infusion of halphaCGRP (2 mug/min) or placebo for 20 min was studied in 12 patients with migraine without aura outside attacks. Xenon-133 inhalation SPECT-determined regional cerebral blood flow (rCBF) and transcranial Doppler (TCD)-determined blood velocity (V (mean)) in the middle cerebral artery (MCA), as well as the heart rate and blood pressure, were the outcome parameters. No change of rCBF was observed at the end of infusion [1.2% +/- 1.7 with halphaCGRP, vs. -1.6% +/- 3.1 with placebo (mean +/- SD)] (P = 0.43). V (mean) in MCA decreased to 13.5% +/- 3.6 with halphaCGRP versus 0.6% +/- 1.8 with placebo (P < 0.005). Since rCBF was unchanged, this indicates a dilation of the MCA. halphaCGRP induced a decrease in MAP (12%) (P < 0.005) and an increase in heart rate (58%) (P < 0.0001). CGRP dilates cerebral arteries, but the effect is so small that it is unlikely to be the only mechanism of CGRP-induced migraine.
KW - Adult
KW - Blood Flow Velocity
KW - Blood Pressure
KW - Calcitonin Gene-Related Peptide
KW - Cerebrovascular Circulation
KW - Cross-Over Studies
KW - Double-Blind Method
KW - Female
KW - Heart Rate
KW - Humans
KW - Male
KW - Middle Aged
KW - Middle Cerebral Artery
KW - Migraine Disorders
KW - Multivariate Analysis
KW - Regional Blood Flow
KW - Time Factors
KW - Tomography, Emission-Computed, Single-Photon
KW - Ultrasonography, Doppler, Transcranial
U2 - 10.1007/s10194-008-0036-8
DO - 10.1007/s10194-008-0036-8
M3 - Journal article
C2 - 18437288
VL - 9
SP - 151
EP - 157
JO - Journal of Headache and Pain
JF - Journal of Headache and Pain
SN - 1129-2369
IS - 3
ER -
ID: 128983286