Is negative self-referent bias an endophenotype for depression? An fMRI study of emotional self-referent words in twins at high vs. low risk of depression
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Is negative self-referent bias an endophenotype for depression? An fMRI study of emotional self-referent words in twins at high vs. low risk of depression. / Miskowiak, Kamilla Woznica; Larsen, J E; Harmer, C J; Siebner, Hartwig Roman; Kessing, Lars Vedel; Macoveanu, J; Vinberg, Maj.
In: Journal of Affective Disorders, Vol. 226, 15.01.2018, p. 267-273.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Is negative self-referent bias an endophenotype for depression? An fMRI study of emotional self-referent words in twins at high vs. low risk of depression
AU - Miskowiak, Kamilla Woznica
AU - Larsen, J E
AU - Harmer, C J
AU - Siebner, Hartwig Roman
AU - Kessing, Lars Vedel
AU - Macoveanu, J
AU - Vinberg, Maj
N1 - Copyright © 2017 Elsevier B.V. All rights reserved.
PY - 2018/1/15
Y1 - 2018/1/15
N2 - BACKGROUND: Negative cognitive bias and aberrant neural processing of self-referent emotional words seem to be trait-marks of depression. However, it is unclear whether these neurocognitive changes are present in unaffected first-degree relatives and constitute an illness endophenotype.METHODS: Fifty-three healthy, never-depressed monozygotic or dizygotic twins with a co-twin history of depression (high-risk group: n = 26) or no first-degree family history of depression (low-risk group: n = 27) underwent neurocognitive testing and functional magnetic imaging (fMRI) as part of a follow-up cohort study. Participants performed a self-referent emotional word categorisation task and free word recall task followed by a recognition task during fMRI. Participants also completed questionnaires assessing mood, personality traits and coping strategies.RESULTS: High-risk and low-risk twins (age, mean ± SD: 40 ± 11) were well-balanced for demographic variables, mood, coping and neuroticism. High-risk twins showed lower accuracy during self-referent categorisation of emotional words independent of valence and more false recollections of negative words than low-risk twins during free recall. Functional MRI yielded no differences between high-risk and low-risk twins in retrieval-specific neural activity for positive or negative words or during the recognition of negative versus positive words within the hippocampus or prefrontal cortex.CONCLUSIONS: The subtle display of negative recall bias is consistent with the hypothesis that self-referent negative memory bias is an endophenotype for depression. High-risk twins' lower categorisation accuracy adds to the evidence for valence-independent cognitive deficits in individuals at familial risk for depression.
AB - BACKGROUND: Negative cognitive bias and aberrant neural processing of self-referent emotional words seem to be trait-marks of depression. However, it is unclear whether these neurocognitive changes are present in unaffected first-degree relatives and constitute an illness endophenotype.METHODS: Fifty-three healthy, never-depressed monozygotic or dizygotic twins with a co-twin history of depression (high-risk group: n = 26) or no first-degree family history of depression (low-risk group: n = 27) underwent neurocognitive testing and functional magnetic imaging (fMRI) as part of a follow-up cohort study. Participants performed a self-referent emotional word categorisation task and free word recall task followed by a recognition task during fMRI. Participants also completed questionnaires assessing mood, personality traits and coping strategies.RESULTS: High-risk and low-risk twins (age, mean ± SD: 40 ± 11) were well-balanced for demographic variables, mood, coping and neuroticism. High-risk twins showed lower accuracy during self-referent categorisation of emotional words independent of valence and more false recollections of negative words than low-risk twins during free recall. Functional MRI yielded no differences between high-risk and low-risk twins in retrieval-specific neural activity for positive or negative words or during the recognition of negative versus positive words within the hippocampus or prefrontal cortex.CONCLUSIONS: The subtle display of negative recall bias is consistent with the hypothesis that self-referent negative memory bias is an endophenotype for depression. High-risk twins' lower categorisation accuracy adds to the evidence for valence-independent cognitive deficits in individuals at familial risk for depression.
KW - Adult
KW - Brain Mapping
KW - Cognition Disorders
KW - Cohort Studies
KW - Depressive Disorder/physiopathology
KW - Emotions/physiology
KW - Endophenotypes
KW - Female
KW - Hippocampus/physiology
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Mental Recall
KW - Prefrontal Cortex/physiology
KW - Twins, Dizygotic
KW - Verbal Behavior/physiology
KW - Depression
KW - Cognition
KW - Familial risk
KW - Endophenotype
KW - FMRI
U2 - 10.1016/j.jad.2017.10.013
DO - 10.1016/j.jad.2017.10.013
M3 - Journal article
C2 - 29020651
VL - 226
SP - 267
EP - 273
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -
ID: 184777062