Lack of association between prior depressive episodes and cerebral [(11)C]PiB binding

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Lack of association between prior depressive episodes and cerebral [(11)C]PiB binding. / Madsen, K; Hasselbalch, Bo Jacob; Frederiksen, K S; Haahr, M E; Gade, Anders; Law, Ian; Price, J C; Knudsen, Gitte Moos; Kessing, Lars Vedel; Hasselbalch, Steen.

In: Neurobiology of Aging, Vol. 33, No. 12, 2012, p. 2334-2342.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Madsen, K, Hasselbalch, BJ, Frederiksen, KS, Haahr, ME, Gade, A, Law, I, Price, JC, Knudsen, GM, Kessing, LV & Hasselbalch, S 2012, 'Lack of association between prior depressive episodes and cerebral [(11)C]PiB binding', Neurobiology of Aging, vol. 33, no. 12, pp. 2334-2342. https://doi.org/10.1016/j.neurobiolaging.2011.11.021, https://doi.org/10.1016/j.neurobiolaging.2011.11.021

APA

Madsen, K., Hasselbalch, B. J., Frederiksen, K. S., Haahr, M. E., Gade, A., Law, I., Price, J. C., Knudsen, G. M., Kessing, L. V., & Hasselbalch, S. (2012). Lack of association between prior depressive episodes and cerebral [(11)C]PiB binding. Neurobiology of Aging, 33(12), 2334-2342. https://doi.org/10.1016/j.neurobiolaging.2011.11.021, https://doi.org/10.1016/j.neurobiolaging.2011.11.021

Vancouver

Madsen K, Hasselbalch BJ, Frederiksen KS, Haahr ME, Gade A, Law I et al. Lack of association between prior depressive episodes and cerebral [(11)C]PiB binding. Neurobiology of Aging. 2012;33(12):2334-2342. https://doi.org/10.1016/j.neurobiolaging.2011.11.021, https://doi.org/10.1016/j.neurobiolaging.2011.11.021

Author

Madsen, K ; Hasselbalch, Bo Jacob ; Frederiksen, K S ; Haahr, M E ; Gade, Anders ; Law, Ian ; Price, J C ; Knudsen, Gitte Moos ; Kessing, Lars Vedel ; Hasselbalch, Steen. / Lack of association between prior depressive episodes and cerebral [(11)C]PiB binding. In: Neurobiology of Aging. 2012 ; Vol. 33, No. 12. pp. 2334-2342.

Bibtex

@article{764cec0a05644f2d80ba34a432c0fa49,
title = "Lack of association between prior depressive episodes and cerebral [(11)C]PiB binding",
abstract = "Depressive symptoms are frequent in Alzheimer's disease (AD), but it is controversial whether depression is a risk factor for AD. This study measured for the first time cortical amyloid-{\ss} (A{\ss}) levels using [(11)C] Pittsburgh Compound B (PiB) positron emission tomography (PET) in a group of nondemented patients with prior depressive episodes. Twenty-eight elderly patients (mean age 61 years, range 51-75, 18 women) with onset of first depressive episode more than 6 years ago but now remitted from depression and 18 healthy subjects (mean age 61 years, range 50-76, 12 women) were included. All subjects were investigated with cognitive testing, 3T magnetic resonance imaging (MRI) and [(11)C]PiB high resolution research tomography (HRRT) positron emission tomography scan. There was no between-groups difference in [(11)C]PiB binding (p = 0.5) and no associations to number of depressive episodes, cognitive performance, or antidepressant treatment. Patients with late onset of depression had increased severity of white matter lesions (p = 0.04). In this study depressive episodes were not associated with increased levels of [(11)C]PiB. Thus, our results do not support the notion that depressive episodes previously in life are a risk factor for developing AD.",
author = "K Madsen and Hasselbalch, {Bo Jacob} and Frederiksen, {K S} and Haahr, {M E} and Anders Gade and Ian Law and Price, {J C} and Knudsen, {Gitte Moos} and Kessing, {Lars Vedel} and Steen Hasselbalch",
note = "Copyright {\textcopyright} 2011 Elsevier Inc. All rights reserved.",
year = "2012",
doi = "10.1016/j.neurobiolaging.2011.11.021",
language = "English",
volume = "33",
pages = "2334--2342",
journal = "Neurobiology of Aging",
issn = "0197-4580",
publisher = "Elsevier",
number = "12",

}

RIS

TY - JOUR

T1 - Lack of association between prior depressive episodes and cerebral [(11)C]PiB binding

AU - Madsen, K

AU - Hasselbalch, Bo Jacob

AU - Frederiksen, K S

AU - Haahr, M E

AU - Gade, Anders

AU - Law, Ian

AU - Price, J C

AU - Knudsen, Gitte Moos

AU - Kessing, Lars Vedel

AU - Hasselbalch, Steen

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2012

Y1 - 2012

N2 - Depressive symptoms are frequent in Alzheimer's disease (AD), but it is controversial whether depression is a risk factor for AD. This study measured for the first time cortical amyloid-ß (Aß) levels using [(11)C] Pittsburgh Compound B (PiB) positron emission tomography (PET) in a group of nondemented patients with prior depressive episodes. Twenty-eight elderly patients (mean age 61 years, range 51-75, 18 women) with onset of first depressive episode more than 6 years ago but now remitted from depression and 18 healthy subjects (mean age 61 years, range 50-76, 12 women) were included. All subjects were investigated with cognitive testing, 3T magnetic resonance imaging (MRI) and [(11)C]PiB high resolution research tomography (HRRT) positron emission tomography scan. There was no between-groups difference in [(11)C]PiB binding (p = 0.5) and no associations to number of depressive episodes, cognitive performance, or antidepressant treatment. Patients with late onset of depression had increased severity of white matter lesions (p = 0.04). In this study depressive episodes were not associated with increased levels of [(11)C]PiB. Thus, our results do not support the notion that depressive episodes previously in life are a risk factor for developing AD.

AB - Depressive symptoms are frequent in Alzheimer's disease (AD), but it is controversial whether depression is a risk factor for AD. This study measured for the first time cortical amyloid-ß (Aß) levels using [(11)C] Pittsburgh Compound B (PiB) positron emission tomography (PET) in a group of nondemented patients with prior depressive episodes. Twenty-eight elderly patients (mean age 61 years, range 51-75, 18 women) with onset of first depressive episode more than 6 years ago but now remitted from depression and 18 healthy subjects (mean age 61 years, range 50-76, 12 women) were included. All subjects were investigated with cognitive testing, 3T magnetic resonance imaging (MRI) and [(11)C]PiB high resolution research tomography (HRRT) positron emission tomography scan. There was no between-groups difference in [(11)C]PiB binding (p = 0.5) and no associations to number of depressive episodes, cognitive performance, or antidepressant treatment. Patients with late onset of depression had increased severity of white matter lesions (p = 0.04). In this study depressive episodes were not associated with increased levels of [(11)C]PiB. Thus, our results do not support the notion that depressive episodes previously in life are a risk factor for developing AD.

U2 - 10.1016/j.neurobiolaging.2011.11.021

DO - 10.1016/j.neurobiolaging.2011.11.021

M3 - Journal article

C2 - 22192243

VL - 33

SP - 2334

EP - 2342

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

IS - 12

ER -

ID: 40159058