Lack of reproducibility of resting-state functional MRI findings in migraine with aura
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Lack of reproducibility of resting-state functional MRI findings in migraine with aura. / Hougaard, Anders; Gaist, David; Garde, Ellen; Iversen, Pernille; Madsen, Camilla G.; Kyvik, Kirsten O.; Ashina, Messoud; Siebner, Hartwig R.; Madsen, Kristoffer H.
In: Cephalalgia : an international journal of headache, Vol. 43, No. 11, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Lack of reproducibility of resting-state functional MRI findings in migraine with aura
AU - Hougaard, Anders
AU - Gaist, David
AU - Garde, Ellen
AU - Iversen, Pernille
AU - Madsen, Camilla G.
AU - Kyvik, Kirsten O.
AU - Ashina, Messoud
AU - Siebner, Hartwig R.
AU - Madsen, Kristoffer H.
PY - 2023
Y1 - 2023
N2 - BACKGROUND: Several studies have applied resting-state functional MRI to examine whether functional brain connectivity is altered in migraine with aura patients. These studies had multiple limitations, including small sample sizes, and reported conflicting results. Here, we performed a large, cross-sectional brain imaging study to reproduce previous findings. METHODS: We recruited women aged 30-60 years from the nationwide Danish Twin Registry. Resting-state functional MRI of women with migraine with aura, their co-twins, and unrelated migraine-free twins was performed at a single centre. We carried out an extensive series of brain connectivity data analyses. Patients were compared to migraine-free controls and to co-twins. RESULTS: Comparisons were based on data from 160 patients, 30 co-twins, and 136 controls. Patients were similar to controls with regard to age, and several lifestyle characteristics. We replicated clear effects of age on resting-state networks. In contrast, we failed to detect any differences, and to replicate previously reported differences, in functional connectivity between migraine patients with aura and non-migraine controls or their co-twins in any of the analyses. CONCLUSION: Given the large sample size and the unbiased population-based design of our study, we conclude that women with migraine with aura have normal resting-state brain connectivity outside of migraine attacks.
AB - BACKGROUND: Several studies have applied resting-state functional MRI to examine whether functional brain connectivity is altered in migraine with aura patients. These studies had multiple limitations, including small sample sizes, and reported conflicting results. Here, we performed a large, cross-sectional brain imaging study to reproduce previous findings. METHODS: We recruited women aged 30-60 years from the nationwide Danish Twin Registry. Resting-state functional MRI of women with migraine with aura, their co-twins, and unrelated migraine-free twins was performed at a single centre. We carried out an extensive series of brain connectivity data analyses. Patients were compared to migraine-free controls and to co-twins. RESULTS: Comparisons were based on data from 160 patients, 30 co-twins, and 136 controls. Patients were similar to controls with regard to age, and several lifestyle characteristics. We replicated clear effects of age on resting-state networks. In contrast, we failed to detect any differences, and to replicate previously reported differences, in functional connectivity between migraine patients with aura and non-migraine controls or their co-twins in any of the analyses. CONCLUSION: Given the large sample size and the unbiased population-based design of our study, we conclude that women with migraine with aura have normal resting-state brain connectivity outside of migraine attacks.
KW - Connectivity
KW - functional imaging
KW - neuroimaging
U2 - 10.1177/03331024231212574
DO - 10.1177/03331024231212574
M3 - Journal article
C2 - 37950678
AN - SCOPUS:85176991503
VL - 43
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 11
ER -
ID: 374406252