Locus Coeruleus Shows a Spatial Pattern of Structural Disintegration in Parkinson's Disease
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Locus Coeruleus Shows a Spatial Pattern of Structural Disintegration in Parkinson's Disease. / Madelung, Christopher F.; Meder, David; Fuglsang, Soren A.; Marques, Marta M.; Boer, Vincent O.; Madsen, Kristoffer H.; Petersen, Esben T.; Hejl, Anne-Mette; Lokkegaard, Annemette; Siebner, Hartwig R.
In: Movement Disorders, Vol. 37, No. 3, 03.2022, p. 479-489.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Locus Coeruleus Shows a Spatial Pattern of Structural Disintegration in Parkinson's Disease
AU - Madelung, Christopher F.
AU - Meder, David
AU - Fuglsang, Soren A.
AU - Marques, Marta M.
AU - Boer, Vincent O.
AU - Madsen, Kristoffer H.
AU - Petersen, Esben T.
AU - Hejl, Anne-Mette
AU - Lokkegaard, Annemette
AU - Siebner, Hartwig R.
PY - 2022/3
Y1 - 2022/3
N2 - Background Parkinson's disease (PD) causes a loss of neuromelanin-positive, noradrenergic neurons in the locus coeruleus (LC), which has been implicated in nonmotor dysfunction. Objectives We used "neuromelanin sensitive" magnetic resonance imaging (MRI) to localize structural disintegration in the LC and its association with nonmotor dysfunction in PD. Methods A total of 42 patients with PD and 24 age-matched healthy volunteers underwent magnetization transfer weighted (MTw) MRI of the LC. The contrast-to-noise ratio of the MTw signal (CNRMTw) was used as an index of structural LC integrity. We performed slicewise and voxelwise analyses to map spatial patterns of structural disintegration, complemented by principal component analysis (PCA). We also tested for correlations between regional CNRMTw and severity of nonmotor symptoms. Results Mean CNRMTw of the right LC was reduced in patients relative to controls. Voxelwise and slicewise analyses showed that the attenuation of CNRMTw was confined to the right mid-caudal LC and linked regional CNRMTw to nonmotor symptoms. CNRMTw attenuation in the left mid-caudal LC was associated with the orthostatic drop in systolic blood pressure, whereas CNRMTw attenuation in the caudal most portion of right LC correlated with apathy ratings. PCA identified a bilateral component that was more weakly expressed in patients. This component was characterized by a gradient in CNRMTw along the rostro-caudal and dorso-ventral axes of the nucleus. The individual expression score of this component reflected the overall severity of nonmotor symptoms. Conclusion A spatially heterogeneous disintegration of LC in PD may determine the individual expression of specific nonmotor symptoms such as orthostatic dysregulation or apathy. (c) 2022 International Parkinson and Movement Disorder Society
AB - Background Parkinson's disease (PD) causes a loss of neuromelanin-positive, noradrenergic neurons in the locus coeruleus (LC), which has been implicated in nonmotor dysfunction. Objectives We used "neuromelanin sensitive" magnetic resonance imaging (MRI) to localize structural disintegration in the LC and its association with nonmotor dysfunction in PD. Methods A total of 42 patients with PD and 24 age-matched healthy volunteers underwent magnetization transfer weighted (MTw) MRI of the LC. The contrast-to-noise ratio of the MTw signal (CNRMTw) was used as an index of structural LC integrity. We performed slicewise and voxelwise analyses to map spatial patterns of structural disintegration, complemented by principal component analysis (PCA). We also tested for correlations between regional CNRMTw and severity of nonmotor symptoms. Results Mean CNRMTw of the right LC was reduced in patients relative to controls. Voxelwise and slicewise analyses showed that the attenuation of CNRMTw was confined to the right mid-caudal LC and linked regional CNRMTw to nonmotor symptoms. CNRMTw attenuation in the left mid-caudal LC was associated with the orthostatic drop in systolic blood pressure, whereas CNRMTw attenuation in the caudal most portion of right LC correlated with apathy ratings. PCA identified a bilateral component that was more weakly expressed in patients. This component was characterized by a gradient in CNRMTw along the rostro-caudal and dorso-ventral axes of the nucleus. The individual expression score of this component reflected the overall severity of nonmotor symptoms. Conclusion A spatially heterogeneous disintegration of LC in PD may determine the individual expression of specific nonmotor symptoms such as orthostatic dysregulation or apathy. (c) 2022 International Parkinson and Movement Disorder Society
KW - Parkinson's disease
KW - locus coeruleus
KW - MRI
KW - non-motor
KW - noradrenaline
KW - IN-VIVO VISUALIZATION
KW - SUBSTANTIA-NIGRA
KW - MRI CONTRAST
KW - COERULEUS/SUBCOERULEUS COMPLEX
KW - ORTHOSTATIC HYPOTENSION
KW - NEURONS
KW - CERULEUS
KW - VALIDATION
KW - DEPRESSION
KW - ALZHEIMER
U2 - 10.1002/mds.28945
DO - 10.1002/mds.28945
M3 - Journal article
C2 - 35114035
VL - 37
SP - 479
EP - 489
JO - Movement Disorders
JF - Movement Disorders
SN - 0885-3185
IS - 3
ER -
ID: 314705933