Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: an [18F]-altanserin PET study

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: an [18F]-altanserin PET study. / Marner, Lisbeth; Knudsen, Gitte M; Haugbøl, Steven; Holm, Søren; Baaré, William; Hasselbalch, Steen G.

In: European Journal of Nuclear Medicine and Molecular Imaging, Vol. 36, No. 2, 2009, p. 287-293.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Marner, L, Knudsen, GM, Haugbøl, S, Holm, S, Baaré, W & Hasselbalch, SG 2009, 'Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: an [18F]-altanserin PET study', European Journal of Nuclear Medicine and Molecular Imaging, vol. 36, no. 2, pp. 287-293. https://doi.org/10.1007/s00259-008-0945-4

APA

Marner, L., Knudsen, G. M., Haugbøl, S., Holm, S., Baaré, W., & Hasselbalch, S. G. (2009). Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: an [18F]-altanserin PET study. European Journal of Nuclear Medicine and Molecular Imaging, 36(2), 287-293. https://doi.org/10.1007/s00259-008-0945-4

Vancouver

Marner L, Knudsen GM, Haugbøl S, Holm S, Baaré W, Hasselbalch SG. Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: an [18F]-altanserin PET study. European Journal of Nuclear Medicine and Molecular Imaging. 2009;36(2):287-293. https://doi.org/10.1007/s00259-008-0945-4

Author

Marner, Lisbeth ; Knudsen, Gitte M ; Haugbøl, Steven ; Holm, Søren ; Baaré, William ; Hasselbalch, Steen G. / Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: an [18F]-altanserin PET study. In: European Journal of Nuclear Medicine and Molecular Imaging. 2009 ; Vol. 36, No. 2. pp. 287-293.

Bibtex

@article{6eb6e6a0626a11df928f000ea68e967b,
title = "Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: an [18F]-altanserin PET study",
abstract = "PURPOSE: The serotonin 2A (5-HT(2A)) receptor is of interest in several psychiatric and neurological diseases. In the present study we investigated the longitudinal stability of 5-HT(2A) receptors and the stability of the quantification procedure in the elderly in order to be able to study elderly patients with neuropsychiatric diseases on a longitudinal basis. METHODS: [(18)F]-Altanserin PET was used to quantify 5-HT(2A) receptors in 12 healthy elderly individuals at baseline and at 2 years in six volumes of interest. A bolus/infusion protocol was used to achieve the binding potential, BP(P). The reproducibility as assessed in terms of variability and the reliability as assessed in terms of intraclass correlation coefficient (ICC) were used to compare inter- and intraobserver stability and to evaluate the effects of increasing complexity of partial volume (PV) corrections. We also compared the stability of our measurements over 2 years with the stability of data from an earlier study with 2-week test-retest measurements. RESULTS: BP(P) was unaltered at follow-up without the use of PV correction and when applying two-tissue PV correction, test-retest reproducibility was 12-15% and reliability 0.45-0.67 in the large bilateral regions such as the parietal, temporal, occipital and frontal cortices, while orbitofrontal and anterior cingulate cortical regions were less stable. The use of PV correction decreased the variability but also decreased the between-subject variation, thereby worsening the reliability. CONCLUSION: In healthy elderly individuals, brain 5-HT(2A) receptor binding remains stable over 2 years, and acceptable reproducibility and reliability in larger regions and high intra- and interobserver stability allow the use of [(18)F]-altanserin in longitudinal studies of patients with neuropsychiatric disorders Udgivelsesdato: 2009/2",
keywords = "Aged, Cerebrum, Female, Fluorine Radioisotopes, Health, Humans, Ketanserin, Longitudinal Studies, Male, Middle Aged, Observer Variation, Positron-Emission Tomography, Receptor, Serotonin, 5-HT2A, Reproducibility of Results",
author = "Lisbeth Marner and Knudsen, {Gitte M} and Steven Haugb{\o}l and S{\o}ren Holm and William Baar{\'e} and Hasselbalch, {Steen G}",
year = "2009",
doi = "10.1007/s00259-008-0945-4",
language = "English",
volume = "36",
pages = "287--293",
journal = "European Journal of Nuclear Medicine and Molecular Imaging",
issn = "1619-7070",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Longitudinal assessment of cerebral 5-HT2A receptors in healthy elderly volunteers: an [18F]-altanserin PET study

AU - Marner, Lisbeth

AU - Knudsen, Gitte M

AU - Haugbøl, Steven

AU - Holm, Søren

AU - Baaré, William

AU - Hasselbalch, Steen G

PY - 2009

Y1 - 2009

N2 - PURPOSE: The serotonin 2A (5-HT(2A)) receptor is of interest in several psychiatric and neurological diseases. In the present study we investigated the longitudinal stability of 5-HT(2A) receptors and the stability of the quantification procedure in the elderly in order to be able to study elderly patients with neuropsychiatric diseases on a longitudinal basis. METHODS: [(18)F]-Altanserin PET was used to quantify 5-HT(2A) receptors in 12 healthy elderly individuals at baseline and at 2 years in six volumes of interest. A bolus/infusion protocol was used to achieve the binding potential, BP(P). The reproducibility as assessed in terms of variability and the reliability as assessed in terms of intraclass correlation coefficient (ICC) were used to compare inter- and intraobserver stability and to evaluate the effects of increasing complexity of partial volume (PV) corrections. We also compared the stability of our measurements over 2 years with the stability of data from an earlier study with 2-week test-retest measurements. RESULTS: BP(P) was unaltered at follow-up without the use of PV correction and when applying two-tissue PV correction, test-retest reproducibility was 12-15% and reliability 0.45-0.67 in the large bilateral regions such as the parietal, temporal, occipital and frontal cortices, while orbitofrontal and anterior cingulate cortical regions were less stable. The use of PV correction decreased the variability but also decreased the between-subject variation, thereby worsening the reliability. CONCLUSION: In healthy elderly individuals, brain 5-HT(2A) receptor binding remains stable over 2 years, and acceptable reproducibility and reliability in larger regions and high intra- and interobserver stability allow the use of [(18)F]-altanserin in longitudinal studies of patients with neuropsychiatric disorders Udgivelsesdato: 2009/2

AB - PURPOSE: The serotonin 2A (5-HT(2A)) receptor is of interest in several psychiatric and neurological diseases. In the present study we investigated the longitudinal stability of 5-HT(2A) receptors and the stability of the quantification procedure in the elderly in order to be able to study elderly patients with neuropsychiatric diseases on a longitudinal basis. METHODS: [(18)F]-Altanserin PET was used to quantify 5-HT(2A) receptors in 12 healthy elderly individuals at baseline and at 2 years in six volumes of interest. A bolus/infusion protocol was used to achieve the binding potential, BP(P). The reproducibility as assessed in terms of variability and the reliability as assessed in terms of intraclass correlation coefficient (ICC) were used to compare inter- and intraobserver stability and to evaluate the effects of increasing complexity of partial volume (PV) corrections. We also compared the stability of our measurements over 2 years with the stability of data from an earlier study with 2-week test-retest measurements. RESULTS: BP(P) was unaltered at follow-up without the use of PV correction and when applying two-tissue PV correction, test-retest reproducibility was 12-15% and reliability 0.45-0.67 in the large bilateral regions such as the parietal, temporal, occipital and frontal cortices, while orbitofrontal and anterior cingulate cortical regions were less stable. The use of PV correction decreased the variability but also decreased the between-subject variation, thereby worsening the reliability. CONCLUSION: In healthy elderly individuals, brain 5-HT(2A) receptor binding remains stable over 2 years, and acceptable reproducibility and reliability in larger regions and high intra- and interobserver stability allow the use of [(18)F]-altanserin in longitudinal studies of patients with neuropsychiatric disorders Udgivelsesdato: 2009/2

KW - Aged

KW - Cerebrum

KW - Female

KW - Fluorine Radioisotopes

KW - Health

KW - Humans

KW - Ketanserin

KW - Longitudinal Studies

KW - Male

KW - Middle Aged

KW - Observer Variation

KW - Positron-Emission Tomography

KW - Receptor, Serotonin, 5-HT2A

KW - Reproducibility of Results

U2 - 10.1007/s00259-008-0945-4

DO - 10.1007/s00259-008-0945-4

M3 - Journal article

C2 - 18828013

VL - 36

SP - 287

EP - 293

JO - European Journal of Nuclear Medicine and Molecular Imaging

JF - European Journal of Nuclear Medicine and Molecular Imaging

SN - 1619-7070

IS - 2

ER -

ID: 19797678