Low frequency oscillations in cephalic vessels assessed by near infrared spectroscopy
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Low frequency oscillations in cephalic vessels assessed by near infrared spectroscopy. / Phillip, Dorte; Schytz, Henrik W; Selb, Juliette; Payne, Stephen; Iversen, Helle Klingenberg; Skovgaard, Lene T; Boas, David A; Ashina, Messoud.
In: European Journal of Clinical Investigation, Vol. 42, No. 11, 11.2012, p. 1180-8.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Low frequency oscillations in cephalic vessels assessed by near infrared spectroscopy
AU - Phillip, Dorte
AU - Schytz, Henrik W
AU - Selb, Juliette
AU - Payne, Stephen
AU - Iversen, Helle Klingenberg
AU - Skovgaard, Lene T
AU - Boas, David A
AU - Ashina, Messoud
N1 - © 2012 The Authors. European Journal of Clinical Investigation © 2012 Stichting European Society for Clinical Investigation Journal Foundation.
PY - 2012/11
Y1 - 2012/11
N2 - BACKGROUND AND METHODS: Low frequency oscillations (LFO) of cerebral vessels are believed to reflect cerebral autoregulation. We investigated day-to-day and hemispheric variations in 0.1 Hz LFO with near infrared spectroscopy (NIRS) and transcranial Doppler (TCD) to determine phase shift and gain of oxygenated haemoglobin (oxyHb) and the velocity of the middle cerebral artery (Vmca) to the arterial blood pressure (ABP). The direct left-right phase shifts of oxyHb and Vmca were also assessed. We examined 44 healthy volunteers by simultaneous recordings of ABP, oxyHb and Vmca during spontaneous and paced breathing at 6 breaths per minute on two separate days.RESULTS: The variation between hemispheres had a prediction interval (PI) of ± 39° for ABP-oxyHb phase shift and ± 69% for gain. ABP-Vmca showed ± 57° PI phase shift and ± 158% PI for gain. The variation from day to day showed ± 61° PI for ABP-oxyHb phase shift and ± 297% PI for gain. ABP-Vmca showed ± 45° PI phase shift and ± 166% PI for gain. We found a linear relation between phase shift of oxyHb and Vmca at paced breathing (P=0.0005), but not at rest (P=0.235).CONCLUSION: Our results show that LFO phase shift ABP-oxyHb may be used as a robust measurement of differences in autoregulation between hemispheres and over time. In addition, we found a strong relation between oxyHb and Vmca during paced breathing. Gain showed too large variation for clinical use, as the SD was up to 100-fold of mean values.
AB - BACKGROUND AND METHODS: Low frequency oscillations (LFO) of cerebral vessels are believed to reflect cerebral autoregulation. We investigated day-to-day and hemispheric variations in 0.1 Hz LFO with near infrared spectroscopy (NIRS) and transcranial Doppler (TCD) to determine phase shift and gain of oxygenated haemoglobin (oxyHb) and the velocity of the middle cerebral artery (Vmca) to the arterial blood pressure (ABP). The direct left-right phase shifts of oxyHb and Vmca were also assessed. We examined 44 healthy volunteers by simultaneous recordings of ABP, oxyHb and Vmca during spontaneous and paced breathing at 6 breaths per minute on two separate days.RESULTS: The variation between hemispheres had a prediction interval (PI) of ± 39° for ABP-oxyHb phase shift and ± 69% for gain. ABP-Vmca showed ± 57° PI phase shift and ± 158% PI for gain. The variation from day to day showed ± 61° PI for ABP-oxyHb phase shift and ± 297% PI for gain. ABP-Vmca showed ± 45° PI phase shift and ± 166% PI for gain. We found a linear relation between phase shift of oxyHb and Vmca at paced breathing (P=0.0005), but not at rest (P=0.235).CONCLUSION: Our results show that LFO phase shift ABP-oxyHb may be used as a robust measurement of differences in autoregulation between hemispheres and over time. In addition, we found a strong relation between oxyHb and Vmca during paced breathing. Gain showed too large variation for clinical use, as the SD was up to 100-fold of mean values.
KW - Adult
KW - Aged
KW - Arterial Pressure
KW - Blood Flow Velocity
KW - Cerebrovascular Circulation
KW - Female
KW - Homeostasis
KW - Humans
KW - Male
KW - Middle Aged
KW - Middle Cerebral Artery
KW - Oxyhemoglobins
KW - Respiration
KW - Spectroscopy, Near-Infrared
KW - Ultrasonography, Doppler, Transcranial
U2 - 10.1111/j.1365-2362.2012.02704.x
DO - 10.1111/j.1365-2362.2012.02704.x
M3 - Journal article
C2 - 22897146
VL - 42
SP - 1180
EP - 1188
JO - Zeitschrift fur klinische Medizin
JF - Zeitschrift fur klinische Medizin
SN - 0014-2972
IS - 11
ER -
ID: 128982467